PMID- 24432634
OWN - NLM
STAT- MEDLINE
DCOM- 20150708
LR  - 20190923
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 31
IP  - 10
DP  - 2013 Oct
TI  - [Rapid determination of total residues of ribavirin and its metabolites in 
      chicken and chicken products by ultra-performance hydrophilic interaction 
      chromatography-tandem mass spectrometry].
PG  - 934-8
AB  - An analytical method was developed for the determination of total residues of 
      ribavirin and its phosphorylated metabolites in chicken and its products by 
      hydrophilic interaction chromatography-tandem mass spectrometry. The samples were 
      extracted with acetonitrile containing 1% (v/v) acetic acid under ultrasonic 
      condition and then enzymatically hydrolysed with acid phosphatase at 37 degrees 
      C. After liposoluble substances being removed with hexane, C18 and PSA dispersion 
      solid phase extraction (DSPE) was introduced to cleanup procedures. The 
      separation was performed on an ultra-performance hydrophilic interaction 
      chromatographic (HILIC) amide column under a gradient elution using acetonitrile 
      and 0.1% formic acid. The analytes were detected in the positive electrospray 
      ionization and multi-reaction monitoring (MRM) mode. In the range of 1-200 
      microg/kg, the correlation coefficient was greater than 0.999. The limit of 
      detection (LOD, S/N > or = 3) was 1 microg/kg and the limit of quantification 
      (LOQ, S/N > or = 10) was 5 microg/kg. The recoveries of ribavirin spiked at three 
      levels ranged from 67.8% to 112.7% with the relative standard deviations (RSDs) 
      of 6.1%-13.6%. The results of the determination of ribavirin in various real 
      samples showed that the method is simple, rapid, accurate and suitable for the 
      determination of total residues of ribavirin and its metabolites in chicken and 
      its products.
FAU - Zhu, Weixia
AU  - Zhu W
AD  - Henan Entry-Exit Inspection and Quarantine Bureau, Zhengzhou 450003, China.
FAU - Yang, Jizhou
AU  - Yang J
AD  - Henan Entry-Exit Inspection and Quarantine Bureau, Zhengzhou 450003, China.
FAU - Yuan, Ping
AU  - Yuan P
AD  - Henan Entry-Exit Inspection and Quarantine Bureau, Zhengzhou 450003, China.
FAU - Sun, Zhuanlian
AU  - Sun Z
AD  - Henan Entry-Exit Inspection and Quarantine Bureau, Zhengzhou 450003, China.
FAU - Wang, Caijuan
AU  - Wang C
AD  - College of Chemistry and Molecular Engineering of Zhengzhou University, Zhengzhou 
      450042, China.
FAU - Sun, Wuyong
AU  - Sun W
AD  - Henan Entry-Exit Inspection and Quarantine Bureau, Zhengzhou 450003, China.
FAU - Zhang, Shusheng
AU  - Zhang S
AD  - College of Chemistry and Molecular Engineering of Zhengzhou University, Zhengzhou 
      450042, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 49717AWG6K (Ribavirin)
SB  - IM
MH  - Animals
MH  - *Chickens
MH  - Chromatography, High Pressure Liquid
MH  - Drug Residues/*analysis
MH  - Food Contamination/*analysis
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Meat/*analysis
MH  - Ribavirin/*analysis
MH  - Solid Phase Extraction
MH  - Tandem Mass Spectrometry
EDAT- 2014/01/18 06:00
MHDA- 2015/07/15 06:00
CRDT- 2014/01/18 06:00
PHST- 2014/01/18 06:00 [entrez]
PHST- 2014/01/18 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - 10.3724/sp.j.1123.2013.01048 [doi]
PST - ppublish
SO  - Se Pu. 2013 Oct;31(10):934-8. doi: 10.3724/sp.j.1123.2013.01048.