PMID- 24432649
OWN - NLM
STAT- MEDLINE
DCOM- 20150708
LR  - 20190923
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 31
IP  - 10
DP  - 2013 Oct
TI  - [Determination of phenolic and salicylanilide anthelmintics in liquid milk by 
      high performance liquid chromatography].
PG  - 1028-32
AB  - An analytical method for the determination of nitroxynil, oxyclozanide, closantel 
      and rafoxanide in liquid milk by high performance liquid chromatography (HPLC) 
      has been established. The milk sample was extracted with acetonitrile containing 
      1% (v/v) triethylamine. The supernatant was purified by an anion exchange solid 
      phase extraction column. The analyte was detected by ultraviolet detector after 
      the HPLC separation on a C18 RP column. The mobile phase was composed of 
      acetonitrile-0.02 mol/L ammonium acetate solution with pH 4.0. The linear ranges 
      of the four drugs in the spiked blank milk samples were 5-500 microg/kg, and the 
      correlation coefficients were higher than 0.99. The limits of detection (LOD) 
      were 3 microg/kg, and the limits of quantification (LOQ) were 5 microg/kg. The 
      average recoveries and relative standard deviations (RSDs) of nitroxynil, 
      oxyclozanide, closantel and rafoxanide at the spiked levels of 1/2MRL (maximum 
      residue limit), MRL and 2MRL ranged from 92.20% to 96.13%, 5.55% to 16.30%; 
      87.40% to 94.74%, 5.40% to 12.21%; 86.97% to 91.09%, 2.67% to 8.17%; and 77.86% 
      to 95.36%, 5.02% to 13.15% respectively. The method is simple and sensitive for 
      the quantification of phenolic and salicylanilide anthelmintics in liquid milk.
FAU - Wang, Wei
AU  - Wang W
AD  - National Reference Laboratory of Veterinary Drug Residues, South China 
      Agricultural University, Guangzhou 510642, China.
FAU - Huang, Xianhui
AU  - Huang X
AD  - National Reference Laboratory of Veterinary Drug Residues, South China 
      Agricultural University, Guangzhou 510642, China.
FAU - Wang, Hui
AU  - Wang H
AD  - National Reference Laboratory of Veterinary Drug Residues, South China 
      Agricultural University, Guangzhou 510642, China.
FAU - Yan, Changyan
AU  - Yan C
AD  - National Reference Laboratory of Veterinary Drug Residues, South China 
      Agricultural University, Guangzhou 510642, China.
FAU - Kong, Xiangkai
AU  - Kong X
AD  - National Reference Laboratory of Veterinary Drug Residues, South China 
      Agricultural University, Guangzhou 510642, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Anthelmintics)
RN  - 0 (Phenols)
RN  - 0 (Salicylanilides)
SB  - IM
MH  - Animals
MH  - Anthelmintics/*analysis
MH  - Chromatography, High Pressure Liquid
MH  - Drug Residues/*analysis
MH  - Food Contamination/*analysis
MH  - Limit of Detection
MH  - Milk/*chemistry
MH  - Phenols/analysis
MH  - Salicylanilides/*analysis
MH  - Solid Phase Extraction
EDAT- 2014/01/18 06:00
MHDA- 2015/07/15 06:00
CRDT- 2014/01/18 06:00
PHST- 2014/01/18 06:00 [entrez]
PHST- 2014/01/18 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - 10.3724/sp.j.1123.2013.03006 [doi]
PST - ppublish
SO  - Se Pu. 2013 Oct;31(10):1028-32. doi: 10.3724/sp.j.1123.2013.03006.