PMID- 24433458
OWN - NLM
STAT- MEDLINE
DCOM- 20140825
LR  - 20220316
IS  - 1741-7015 (Electronic)
IS  - 1741-7015 (Linking)
VI  - 12
DP  - 2014 Jan 16
TI  - Interaction between stress and the BDNF Val66Met polymorphism in depression: a 
      systematic review and meta-analysis.
PG  - 7
LID - 10.1186/1741-7015-12-7 [doi]
AB  - BACKGROUND: Major depression is a disabling psychiatric illness with complex 
      origins. Life stress (childhood adversity and recent stressful events) is a 
      robust risk factor for depression. The relationship between life stress and 
      Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene has 
      received much attention. The aim of the present work was to review and conduct a 
      meta-analysis on the results from published studies examining this interaction. 
      METHODS: A literature search was conducted using PsychINFO and PubMed databases 
      until 22 November 2013. A total of 22 studies with a pooled total of 14,233 
      participants met the inclusion criteria, the results of which were combined and a 
      meta-analysis performed using the Liptak-Stouffer z-score method. RESULTS: The 
      results suggest that the Met allele of BDNF Val66Met significantly moderates the 
      relationship between life stress and depression (P = 0.03). When the studies were 
      stratified by type of environmental stressor, the evidence was stronger for an 
      interaction with stressful life events (P = 0.01) and weaker for interaction of 
      BDNF Val66Met with childhood adversity (P = 0.051). CONCLUSIONS: The interaction 
      between BDNF and life stress in depression is stronger for stressful life events 
      rather than childhood adversity. Methodological limitations of existing studies 
      include poor measurement of life stress.
FAU - Hosang, Georgina M
AU  - Hosang GM
AD  - Psychology Department, Goldsmiths, University of London, New Cross, London SE14 
      6NW, UK. g.hosang@gold.ac.uk.
FAU - Shiles, Celia
AU  - Shiles C
FAU - Tansey, Katherine E
AU  - Tansey KE
FAU - McGuffin, Peter
AU  - McGuffin P
FAU - Uher, Rudolf
AU  - Uher R
LA  - eng
GR  - Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20140116
PL  - England
TA  - BMC Med
JT  - BMC medicine
JID - 101190723
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Depression/diagnosis/*genetics/psychology
MH  - Humans
MH  - Methionine/*genetics
MH  - Polymorphism, Genetic/*genetics
MH  - Stress, Psychological/diagnosis/*genetics/psychology
MH  - Valine/*genetics
PMC - PMC3912923
EDAT- 2014/01/18 06:00
MHDA- 2014/08/26 06:00
PMCR- 2014/01/16
CRDT- 2014/01/18 06:00
PHST- 2013/04/26 00:00 [received]
PHST- 2013/12/24 00:00 [accepted]
PHST- 2014/01/18 06:00 [entrez]
PHST- 2014/01/18 06:00 [pubmed]
PHST- 2014/08/26 06:00 [medline]
PHST- 2014/01/16 00:00 [pmc-release]
AID - 1741-7015-12-7 [pii]
AID - 10.1186/1741-7015-12-7 [doi]
PST - epublish
SO  - BMC Med. 2014 Jan 16;12:7. doi: 10.1186/1741-7015-12-7.