PMID- 24433972
OWN - NLM
STAT- MEDLINE
DCOM- 20140711
LR  - 20220321
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Linking)
VI  - 121
IP  - 5
DP  - 2014 May
TI  - Qualitative and quantitative characteristics of near-infrared autofluorescence in 
      diabetic macular edema.
PG  - 1036-44
LID - S0161-6420(13)01155-X [pii]
LID - 10.1016/j.ophtha.2013.11.033 [doi]
AB  - OBJECTIVE: To study the characteristics of near-infrared autofluorescence 
      (NIR-AF) imaging and its association with spectral-domain optical coherence 
      tomography (SD-OCT) findings and logarithm of the minimal angle of resolution 
      (logMAR) visual acuity (VA) in diabetic macular edema (DME). DESIGN: 
      Retrospective, observational, cross-sectional study. PARTICIPANTS: One hundred 
      twenty-one consecutive eyes of 87 patients with center-involved DME for whom 
      NIR-AF and SD-OCT images of sufficient quality were obtained. METHODS: The NIR-AF 
      images were acquired using Heidelberg Retina Angiograph 2 (Heidelberg 
      Engineering, Heidelberg, Germany), and sectional retinal images were obtained 
      using Spectralis OCT (Heidelberg Engineering). The presence of a mosaic pattern 
      and cystoid signs were determined qualitatively. We quantified the average 
      fluorescence intensity in the central 1-mm subfield. The characteristics of the 
      NIR-AF images were compared with the OCT findings and logMAR VA. MAIN OUTCOME 
      MEASURES: Qualitative and quantitative characteristics of the NIR-AF images and 
      their association with SD-OCT findings and logMAR VA. RESULTS: Fifty-seven eyes 
      with a mosaic pattern in the NIR-AF macular images had worse logMAR VA 
      (0.355+/-0.239 vs. 0.212+/-0.235; P = 0.001), a thicker central subfield (CSF) 
      (530+/-143 mum vs. 438+/-105 mum; P <0.001), and disrupted external limiting membrane 
      (ELM; P <0.001) compared with 64 eyes without these findings. Forty-one eyes with 
      a cystoid sign in the NIR-AF images had worse logMAR VA (0.393+/-0.233 vs. 
      0.221+/-0.234; P <0.001) and a thicker CSF (557+/-155 mum vs. 443+/-100 mum; P <0.001) 
      than those without them; there were no significant differences in the ELM status. 
      The relative fluorescence intensity in the central subfield in the NIR-AF images 
      was correlated negatively with the CSF thickness and logMAR VA (R = 0.492, 
      P <0.001 and R = 0.377, P <0.001, respectively). Eyes with foveal serous retinal 
      detachment had lower levels of relative fluorescence intensity than those without 
      it (0.751+/-0.191 vs. 0.877+/-0.154; P = 0.007); there was no association with the 
      presence of foveal cystoid spaces, disrupted ELM, or hyperreflective foci in the 
      outer retinal layers. CONCLUSIONS: Novel qualitative and quantitative NIR-AF 
      characteristics in the macula indicated the clinical relevance and suggested the 
      pathogenesis in DME.
CI  - Copyright (c) 2014 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Yoshitake, Shin
AU  - Yoshitake S
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan.
FAU - Murakami, Tomoaki
AU  - Murakami T
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan. Electronic address: mutomo@kuhp.kyoto-u.ac.jp.
FAU - Horii, Takahiro
AU  - Horii T
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan.
FAU - Uji, Akihito
AU  - Uji A
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan.
FAU - Ogino, Ken
AU  - Ogino K
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan.
FAU - Unoki, Noriyuki
AU  - Unoki N
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan.
FAU - Nishijima, Kazuaki
AU  - Nishijima K
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan.
FAU - Yoshimura, Nagahisa
AU  - Yoshimura N
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20140114
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - Diabetic Retinopathy/*diagnosis
MH  - Female
MH  - *Fluorescein Angiography
MH  - Humans
MH  - *Infrared Rays
MH  - Macula Lutea/pathology
MH  - Macular Edema/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Optical Imaging
MH  - Retinal Pigment Epithelium/pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
EDAT- 2014/01/18 06:00
MHDA- 2014/07/12 06:00
CRDT- 2014/01/18 06:00
PHST- 2013/07/02 00:00 [received]
PHST- 2013/11/15 00:00 [revised]
PHST- 2013/11/18 00:00 [accepted]
PHST- 2014/01/18 06:00 [entrez]
PHST- 2014/01/18 06:00 [pubmed]
PHST- 2014/07/12 06:00 [medline]
AID - S0161-6420(13)01155-X [pii]
AID - 10.1016/j.ophtha.2013.11.033 [doi]
PST - ppublish
SO  - Ophthalmology. 2014 May;121(5):1036-44. doi: 10.1016/j.ophtha.2013.11.033. Epub 
      2014 Jan 14.