PMID- 24434323
OWN - NLM
STAT- MEDLINE
DCOM- 20140623
LR  - 20240323
IS  - 0971-5916 (Print)
IS  - 0975-9174 (Electronic)
IS  - 0971-5916 (Linking)
VI  - 138
IP  - 5
DP  - 2013 Nov
TI  - Inflammation & autoimmunity in human ageing: dendritic cells take a center stage.
PG  - 711-6
AB  - Dendritic cells (DCs) play an important role in both immunological tolerance and 
      immunity as well as in pro- and anti-inflammatory responses. Upon uptake of 
      apoptotic cells and apoptotic bodies, DCs degrade self antigens from them and 
      induce anti-inflammatory response and T regulatory (Treg) cells resulting in the 
      maintenance of tolerance to self antigens. Ageing is characterized by progressive 
      immunodeficiency, inflammation, and autoimmunity. In this paper we will review 
      the role of DCs in inflammation and autoimmunity in human ageing and will 
      highlight the observations that DCs from aged humans display impairment in their 
      capacity to uptake apoptotic cells, and paradoxically induce proinflammatory 
      response and increased reactivity to self antigen (DNA). DNA from aged is 
      hypomethylated and hypomethylation is associated with increased immunogenecity of 
      self DNA.
FAU - Gupta, Sudhir
AU  - Gupta S
AD  - Laboratories in Cellular & Molecular Immunology, Division of Basic & Clinical 
      Immunology, University of California, Irvine, California, USA.
FAU - Agrawal, Anshu
AU  - Agrawal A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - India
TA  - Indian J Med Res
JT  - The Indian journal of medical research
JID - 0374701
RN  - 0 (Cytokines)
SB  - IM
MH  - Aging/*immunology/metabolism
MH  - Apoptosis/immunology
MH  - Autoimmunity/*immunology
MH  - Cytokines/immunology/metabolism
MH  - DNA Methylation/immunology
MH  - Dendritic Cells/*immunology/metabolism
MH  - Humans
MH  - Immune Tolerance
MH  - Inflammation/*immunology/metabolism
MH  - T-Lymphocytes, Regulatory/immunology
PMC - PMC3928701
EDAT- 2014/01/18 06:00
MHDA- 2014/06/24 06:00
PMCR- 2013/11/01
CRDT- 2014/01/18 06:00
PHST- 2014/01/18 06:00 [entrez]
PHST- 2014/01/18 06:00 [pubmed]
PHST- 2014/06/24 06:00 [medline]
PHST- 2013/11/01 00:00 [pmc-release]
AID - IndianJMedRes_2013_138_5_711_124662 [pii]
AID - IJMR-138-711 [pii]
PST - ppublish
SO  - Indian J Med Res. 2013 Nov;138(5):711-6.