PMID- 24435333
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20220316
IS  - 1720-8319 (Electronic)
IS  - 1594-0667 (Linking)
VI  - 26
IP  - 4
DP  - 2014 Aug
TI  - Effects of escitalopram on serum BDNF levels in elderly patients with depression: 
      a preliminary report.
PG  - 461-4
LID - 10.1007/s40520-014-0194-2 [doi]
AB  - BACKGROUND AND AIMS: Increasing evidence in the literature suggests a link 
      between the brain-derived neurotrophic factor (BDNF) system and adult depression, 
      supporting a role in the pathophysiology of the disease and response to therapy. 
      Few studies have reported BDNF serum levels in elderly depressed subjects and 
      their relationship with antidepressant therapy. The aim of the study was to 
      evaluate BDNF serum levels in naive elderly depressed patients, before and after 
      antidepressant treatment. METHODS: We enrolled n = 5 elderly naive patients 
      affected by depression, according to the Diagnostic and Statistical Manual of 
      Mental Disorders-IV Text Revision criteria for major depressive episode. BDNF 
      serum levels were evaluated through ELISA method. Cognitive functions were 
      examined by Mini Mental State Examination (MMSE) and severity of depression was 
      assessed by Geriatric Depression Scale (GDS). BDNF levels were measured at 
      baseline (T0) and after 2 months (T2) of escitalopram. Ten healthy elderly 
      subjects were enrolled as a control group. RESULTS: The serum BDNF levels in 
      patients (T0) and controls were 11.5 +/- 0.6 and 13.6 +/- 3.4 ng/ml (m +/- SD), 
      respectively. At T2, the patients showed a significant improvement of depressive 
      symptoms (p < 0.05), with a not significant increase of MMSE. The serum BDNF 
      concentrations increased to 16.0 +/- 2.7 ng/ml at T2 (p < 0.05), beyond the levels 
      of BDNF in controls. The increase in BDNF levels was significantly related to the 
      improvement in GDS scores of the patients (r = 0.9, p < 0.05). CONCLUSIONS: Serum 
      BDNF levels may be considered as a marker of response to antidepressant treatment 
      for depression in the elderly.
FAU - Martocchia, Antonio
AU  - Martocchia A
AD  - Geriatric Unit, Sapienza University of Rome, S. Andrea Hospital, Via di 
      Grottarossa 1035, 00189, Rome, Italy, a_martocchia@virgilio.it.
FAU - Curto, Martina
AU  - Curto M
FAU - Scaccianoce, Sergio
AU  - Scaccianoce S
FAU - Comite, Fabrizia
AU  - Comite F
FAU - Xenos, Dionysios
AU  - Xenos D
FAU - Nasca, Carla
AU  - Nasca C
FAU - Falaschi, Giulia Maria
AU  - Falaschi GM
FAU - Ferracuti, Stefano
AU  - Ferracuti S
FAU - Girardi, Paolo
AU  - Girardi P
FAU - Nicoletti, Ferdinando
AU  - Nicoletti F
FAU - Falaschi, Paolo
AU  - Falaschi P
LA  - eng
PT  - Journal Article
DEP - 20140117
PL  - Germany
TA  - Aging Clin Exp Res
JT  - Aging clinical and experimental research
JID - 101132995
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0DHU5B8D6V (Citalopram)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - Antidepressive Agents/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Citalopram/*therapeutic use
MH  - Cognition/physiology
MH  - Depression/*blood/*drug therapy
MH  - Depressive Disorder, Major/*blood/*drug therapy
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - Humans
MH  - Male
MH  - Severity of Illness Index
EDAT- 2014/01/18 06:00
MHDA- 2015/03/31 06:00
CRDT- 2014/01/18 06:00
PHST- 2013/10/28 00:00 [received]
PHST- 2014/01/03 00:00 [accepted]
PHST- 2014/01/18 06:00 [entrez]
PHST- 2014/01/18 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - 10.1007/s40520-014-0194-2 [doi]
PST - ppublish
SO  - Aging Clin Exp Res. 2014 Aug;26(4):461-4. doi: 10.1007/s40520-014-0194-2. Epub 
      2014 Jan 17.