PMID- 24436321
OWN - NLM
STAT- MEDLINE
DCOM- 20160219
LR  - 20150609
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Linking)
VI  - 25
IP  - 7
DP  - 2015 Jul
TI  - Transient Maternal Hypothyroxinemia Potentiates the Transcriptional Response to 
      Exogenous Thyroid Hormone in the Fetal Cerebral Cortex Before the Onset of Fetal 
      Thyroid Function: A Messenger and MicroRNA Profiling Study.
PG  - 1735-45
LID - 10.1093/cercor/bht364 [doi]
AB  - Thyroid hormone (TH) is essential for brain development both before and after 
      birth. We have used gene expression microarrays to identify TH-regulated genes in 
      the fetal cerebral cortex prior to the onset of fetal thyroid function to better 
      understand the role of TH in early cortical development. TH levels were 
      transiently manipulated in pregnant mice by treatment with goitrogens from 
      gestational day (GD) 13-16 and/or by injection of TH 12 h before sacrifice on GD 
      16. The transcriptional response to exogenous TH in the GD 16 fetal cortex was 
      potentiated by transient goitrogen treatment, suggesting that the 
      hypothyroxinemic brain is a different substrate upon which TH can act, or that 
      robust compensatory mechanisms are induced by transient hypothyroxinemia. Several 
      known TH-responsive genes were identified including Klf9, and several novel 
      TH-responsive genes such as Appbp2, Ppap2b, and Fgfr1op2 were identified in which 
      TH response elements were confirmed. We also identified specific microRNAs whose 
      expression in the fetal cortex was affected by TH treatment, and determined that 
      Ppap2b and Klf9 are the target genes of miR-16 and miR-106, respectively. Thus, a 
      complex redundant functional network appears to coordinate TH-mediated gene 
      expression in the developing brain.
CI  - (c) The Author 2014. Published by Oxford University Press. All rights reserved. For 
      Permissions, please e-mail: journals.permissions@oup.com.
FAU - Dong, Hongyan
AU  - Dong H
AD  - Environmental Health Science and Research Bureau, Healthy Environments and 
      Consumer Safety Branch, Health Canada, Ottawa, ON, Canada K1A 0K9.
FAU - You, Seo-Hee
AU  - You SH
AD  - Department of Biology and Molecular and Cellular Biology Program, University of 
      Massachusetts, Amherst, MA 01003, USA Current address: Cardiovascular and 
      Metabolism Therapeutic Area, Janssen Pharmaceutical Companies of Johnson & 
      Johnson, LLC, Welsh & McKean Roads, Spring House, PA 19477, USA.
FAU - Williams, Andrew
AU  - Williams A
AD  - Environmental Health Science and Research Bureau, Healthy Environments and 
      Consumer Safety Branch, Health Canada, Ottawa, ON, Canada K1A 0K9.
FAU - Wade, Mike G
AU  - Wade MG
AD  - Environmental Health Science and Research Bureau, Healthy Environments and 
      Consumer Safety Branch, Health Canada, Ottawa, ON, Canada K1A 0K9.
FAU - Yauk, Carole L
AU  - Yauk CL
AD  - Environmental Health Science and Research Bureau, Healthy Environments and 
      Consumer Safety Branch, Health Canada, Ottawa, ON, Canada K1A 0K9.
FAU - Thomas Zoeller, R
AU  - Thomas Zoeller R
AD  - Department of Biology and Molecular and Cellular Biology Program, University of 
      Massachusetts, Amherst, MA 01003, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140115
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
RN  - 0 (Antithyroid Agents)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Messenger)
RN  - 0 (Thyroid Hormones)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Antithyroid Agents
MH  - Cells, Cultured
MH  - Cerebral Cortex/*embryology/*metabolism
MH  - Disease Models, Animal
MH  - Female
MH  - *Gene Expression Regulation, Developmental
MH  - Hypothyroidism/*blood
MH  - Mice, Inbred C57BL
MH  - MicroRNAs/*metabolism
MH  - Microarray Analysis
MH  - Neuroblastoma/metabolism
MH  - Pregnancy
MH  - RNA, Messenger/genetics/*metabolism
MH  - Thyroid Hormones/*administration & dosage/blood/metabolism
MH  - Thyroxine/blood
MH  - Transcription, Genetic
OTO - NOTNLM
OT  - Klf9
OT  - brain development
OT  - methimazole
OT  - miR-106
OT  - microarray
EDAT- 2014/01/18 06:00
MHDA- 2016/02/20 06:00
CRDT- 2014/01/18 06:00
PHST- 2014/01/18 06:00 [entrez]
PHST- 2014/01/18 06:00 [pubmed]
PHST- 2016/02/20 06:00 [medline]
AID - bht364 [pii]
AID - 10.1093/cercor/bht364 [doi]
PST - ppublish
SO  - Cereb Cortex. 2015 Jul;25(7):1735-45. doi: 10.1093/cercor/bht364. Epub 2014 Jan 
      15.