PMID- 24440313
OWN - NLM
STAT- MEDLINE
DCOM- 20140418
LR  - 20140224
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 98
IP  - 1
DP  - 2014 Mar 7
TI  - Adiponectin and peroxisome proliferator-activated receptor-gamma gene polymorphisms 
      and gene-gene interactions with type 2 diabetes.
PG  - 55-9
LID - S0024-3205(14)00052-6 [pii]
LID - 10.1016/j.lfs.2013.12.232 [doi]
AB  - AIMS: To investigate whether gene polymorphisms of both adiponectin and 
      peroxisome proliferator-activated receptor gamma (PPARgamma) influence type 2 
      diabetes mellitus (T2DM) respectively in the Han people of the Wenzhou region of 
      China and whether the interaction of gene polymorphism between adiponectin and 
      PPARgamma influences T2DM in the same subjects. MAIN METHODS: This study included 198 
      patients with T2DM and 255 healthy individuals. Polymerase chain 
      reaction-restriction fragment length polymorphism analyses were used to detect 
      single nucleotide polymorphisms (SNPs). Logistic regression and multifactor 
      dimensionality reduction (MDR) methods were used to analyze gene-gene 
      interactions. KEY FINDINGS: The frequency distribution of adiponectin SNP11377 
      was not different (p=0.792), but the frequency of CC, CG and GG genotypes showed 
      the difference between two groups (T2DM: 57.1%, 33.3%, and 9.6%; control: 53.7%, 
      41.6%, and 4.7%, respectively; p=0.047). Adiponectin SNP45, SNP276 and PPAR gamma 
      SNPp12a were equally distributed between the two groups (p=0.586, 0.119, 0.437, 
      respectively), and there were no significant differences in genotype frequencies 
      between the two groups (p=0.751, 0.144, 0.479, respectively). Linkage 
      disequilibrium existed between SNP11377 and SNP45 (p<0.001) and SNP45 and SNP276 
      (p<0.001). Haplotype analyses showed no significant differences between the T2DM 
      and control groups. According to the logistic regression and MDR gene-gene 
      interaction analyses, SNP11377GG and SNP276GT interactions increased the risk of 
      T2DM (odds ratio=6.984, p=0.012). SIGNIFICANCE: Adiponectin SNP11377 and SNP276 
      gene-gene interactions are associated with the increased risk of T2DM in this 
      population.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Ye, Enling
AU  - Ye E
AD  - Department of Endocrinology, The Third Hospital Affiliate to Wenzhou Medical 
      University, Ruian, Zhejiang 325200, China; Ruian Center of the Chinese-American 
      Research Institute for Diabetic Complications, The Third Affiliated Hospital of 
      the Wenzhou Medical University, Wenzhou 325200, China.
FAU - Yang, Hong
AU  - Yang H
AD  - Department of Endocrinology, The Third Hospital Affiliate to Wenzhou Medical 
      University, Ruian, Zhejiang 325200, China; Ruian Center of the Chinese-American 
      Research Institute for Diabetic Complications, The Third Affiliated Hospital of 
      the Wenzhou Medical University, Wenzhou 325200, China.
FAU - Chen, Liangmiao
AU  - Chen L
AD  - Department of Endocrinology, The Third Hospital Affiliate to Wenzhou Medical 
      University, Ruian, Zhejiang 325200, China; Ruian Center of the Chinese-American 
      Research Institute for Diabetic Complications, The Third Affiliated Hospital of 
      the Wenzhou Medical University, Wenzhou 325200, China.
FAU - Chen, Qingshou
AU  - Chen Q
AD  - Department of Endocrinology, The Third Hospital Affiliate to Wenzhou Medical 
      University, Ruian, Zhejiang 325200, China; Ruian Center of the Chinese-American 
      Research Institute for Diabetic Complications, The Third Affiliated Hospital of 
      the Wenzhou Medical University, Wenzhou 325200, China.
FAU - Sun, Mengli
AU  - Sun M
AD  - Department of Endocrinology, The Third Hospital Affiliate to Wenzhou Medical 
      University, Ruian, Zhejiang 325200, China; Ruian Center of the Chinese-American 
      Research Institute for Diabetic Complications, The Third Affiliated Hospital of 
      the Wenzhou Medical University, Wenzhou 325200, China.
FAU - Lin, Zhenzhen
AU  - Lin Z
AD  - Department of Endocrinology, The Third Hospital Affiliate to Wenzhou Medical 
      University, Ruian, Zhejiang 325200, China; Ruian Center of the Chinese-American 
      Research Institute for Diabetic Complications, The Third Affiliated Hospital of 
      the Wenzhou Medical University, Wenzhou 325200, China.
FAU - Yu, Lechu
AU  - Yu L
AD  - Department of Endocrinology, The Third Hospital Affiliate to Wenzhou Medical 
      University, Ruian, Zhejiang 325200, China; Ruian Center of the Chinese-American 
      Research Institute for Diabetic Complications, The Third Affiliated Hospital of 
      the Wenzhou Medical University, Wenzhou 325200, China.
FAU - Peng, Mengmeng
AU  - Peng M
AD  - Department of Endocrinology, The Third Hospital Affiliate to Wenzhou Medical 
      University, Ruian, Zhejiang 325200, China; Ruian Center of the Chinese-American 
      Research Institute for Diabetic Complications, The Third Affiliated Hospital of 
      the Wenzhou Medical University, Wenzhou 325200, China.
FAU - Zhang, Chi
AU  - Zhang C
AD  - Ruian Center of the Chinese-American Research Institute for Diabetic 
      Complications, The Third Affiliated Hospital of the Wenzhou Medical University, 
      Wenzhou 325200, China; Chinese-American Research Institute for Diabetic 
      Complications, Wenzhou Medical University, Wenzhou 325035, China. Electronic 
      address: zhangchi515@126.com.
FAU - Lu, Xuemian
AU  - Lu X
AD  - Department of Endocrinology, The Third Hospital Affiliate to Wenzhou Medical 
      University, Ruian, Zhejiang 325200, China; Ruian Center of the Chinese-American 
      Research Institute for Diabetic Complications, The Third Affiliated Hospital of 
      the Wenzhou Medical University, Wenzhou 325200, China. Electronic address: 
      lu89118@medmail.com.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140115
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Adiponectin)
RN  - 0 (PPAR gamma)
SB  - IM
MH  - Adiponectin/*genetics
MH  - China
MH  - Diabetes Mellitus, Type 2/*genetics/physiopathology
MH  - *Epistasis, Genetic
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - PPAR gamma/*genetics
MH  - *Polymorphism, Genetic
OTO - NOTNLM
OT  - Adiponectin
OT  - Gene polymorphism
OT  - Gene-gene interaction
OT  - Peroxisome proliferator-activated receptor
OT  - Type 2 diabetes
EDAT- 2014/01/21 06:00
MHDA- 2014/04/20 06:00
CRDT- 2014/01/21 06:00
PHST- 2013/10/31 00:00 [received]
PHST- 2013/12/19 00:00 [revised]
PHST- 2013/12/31 00:00 [accepted]
PHST- 2014/01/21 06:00 [entrez]
PHST- 2014/01/21 06:00 [pubmed]
PHST- 2014/04/20 06:00 [medline]
AID - S0024-3205(14)00052-6 [pii]
AID - 10.1016/j.lfs.2013.12.232 [doi]
PST - ppublish
SO  - Life Sci. 2014 Mar 7;98(1):55-9. doi: 10.1016/j.lfs.2013.12.232. Epub 2014 Jan 
      15.