PMID- 24440317
OWN - NLM
STAT- MEDLINE
DCOM- 20141006
LR  - 20141120
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 152
IP  - 1
DP  - 2014 Feb 27
TI  - Antidepressant-like effects of Xiaochaihutang in a rat model of chronic 
      unpredictable mild stress.
PG  - 217-26
LID - S0378-8741(14)00032-4 [pii]
LID - 10.1016/j.jep.2014.01.006 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Xiaochaihutang (XCHT) has been used in China for 
      thousands of years to treat "Shaoyang syndrome", which involves depressive-like 
      symptoms. However, few studies have investigated its antidepressant effects and 
      pharmacological mechanism of action. The present study was designed to confirm 
      the antidepressant effect of XCHT using a chronic unpredictable mild stress 
      (CUMS) model and explore its potential mechanism of action by investigating the 
      monoamine neurotransmitters (dopamine and 5-hydroxytryptamine) and neurotrophins 
      (BDNF and NGF). MATERIALS AND METHODS: The CUMS model was established in rats, 
      and the antidepressant effect of XCHT (0.6, 1.7 and 5mg/kg/day, given by gastric 
      gavage for 4 weeks) was investigated using the open field test (OFT), food 
      consumption test and sucrose preference test. The concentrations of 5-HT and DA 
      in the hippocampus were measured by high performance liquid chromatography with 
      electrochemical detection (HPLC-ECD). The expressions of brain-derived 
      neurotrophic factor (BDNF), nerve growth factor (NGF), and their receptors 
      tyrosine receptor kinase B (TrkB) and tyrosine receptor kinase A (TrkA) in the 
      hippocampus were measured by immunohistochemical staining analysis. RESULTS: CUMS 
      caused a significant decrease in OFT, food consumption and sucrose preference in 
      rats, and these depression-like behaviors were significantly improved by XCHT 
      (1.7 and 5 g/kg/day). Moreover, XCHT significantly increased the concentrations 
      of 5-HT (0.6 and 5 g/kg/day) and DA (5 g/kg/day), and improved the BDNF, NGF, 
      TrkB and TrkA expressions in the hippocampus (1.7 and 5 g/kg/day), which was 
      reduced in CUMS rats. CONCLUSION: The results obtained suggested that XCHT may 
      have therapeutic actions on depression-like behavior induced by CUMS in rats 
      possibly mediated by increasing the monoamine neurotransmitter concentration and 
      neurotrophin expression in the hippocampus.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Su, Guang Yue
AU  - Su GY
AD  - Department of Pharmacology, Shenyang Pharmaceutical University, Box 31, 103 
      Wenhua Road, 110016 Shenyang, PR China.
FAU - Yang, Jing Yu
AU  - Yang JY
AD  - Department of Pharmacology, Shenyang Pharmaceutical University, Box 31, 103 
      Wenhua Road, 110016 Shenyang, PR China.
FAU - Wang, Fang
AU  - Wang F
AD  - Department of Pharmacology, Shenyang Pharmaceutical University, Box 31, 103 
      Wenhua Road, 110016 Shenyang, PR China.
FAU - Ma, Jie
AU  - Ma J
AD  - Department of Pharmacology, Shenyang Pharmaceutical University, Box 31, 103 
      Wenhua Road, 110016 Shenyang, PR China.
FAU - Zhang, Kuo
AU  - Zhang K
AD  - Department of Pharmacology, Shenyang Pharmaceutical University, Box 31, 103 
      Wenhua Road, 110016 Shenyang, PR China.
FAU - Dong, Ying Xu
AU  - Dong YX
AD  - Department of Pharmacology, Shenyang Pharmaceutical University, Box 31, 103 
      Wenhua Road, 110016 Shenyang, PR China.
FAU - Song, Shao Jiang
AU  - Song SJ
AD  - Department of Traditional Chinese Materia Medica, Shenyang Pharmaceutical 
      University, 110016 Shenyang, PR China.
FAU - Lu, Xiu Mei
AU  - Lu XM
AD  - Department of pharmaceutical analysis, Shenyang Pharmaceutical University, 110016 
      Shenyang, China.
FAU - Wu, Chun Fu
AU  - Wu CF
AD  - Department of Pharmacology, Shenyang Pharmaceutical University, Box 31, 103 
      Wenhua Road, 110016 Shenyang, PR China. Electronic address: wucf@syphu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140115
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (shosaiko-to)
RN  - 333DO1RDJY (Serotonin)
RN  - 57-50-1 (Sucrose)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/administration & dosage/*pharmacology
MH  - Behavior, Animal/drug effects
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Chromatography, High Pressure Liquid
MH  - Chronic Disease
MH  - Depression/*drug therapy
MH  - Disease Models, Animal
MH  - Dopamine/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Drugs, Chinese Herbal/administration & dosage/*pharmacology
MH  - Hippocampus/drug effects
MH  - Male
MH  - Nerve Growth Factor/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/metabolism
MH  - Stress, Psychological/*drug therapy
MH  - Sucrose/administration & dosage
OTO - NOTNLM
OT  - 5-Hydroxytryptamine (PubChem CID: 5202)
OT  - Antidepressant
OT  - Baicalein (PubChem CID: 5281605)
OT  - Baicalin (PubChem CID: 64982)
OT  - CUMS
OT  - Dopamine (PubChem CID: 681)
OT  - Ginsenoside Rg(1) (PubChem CID: 441923)
OT  - Glycyrrhizic acid (PubChem CID: 14982)
OT  - Isoliquiritin (PubChem CID: 5318591)
OT  - Liquiritin (PubChem CID: 503737)
OT  - Monoamine
OT  - Neurotrophin
OT  - Saikosaponin A (PubChem CID: 167928)
OT  - Wogonin (PubChem CID: 5281703)
OT  - Xiaochaihutang
EDAT- 2014/01/21 06:00
MHDA- 2014/10/07 06:00
CRDT- 2014/01/21 06:00
PHST- 2013/08/30 00:00 [received]
PHST- 2013/11/14 00:00 [revised]
PHST- 2014/01/07 00:00 [accepted]
PHST- 2014/01/21 06:00 [entrez]
PHST- 2014/01/21 06:00 [pubmed]
PHST- 2014/10/07 06:00 [medline]
AID - S0378-8741(14)00032-4 [pii]
AID - 10.1016/j.jep.2014.01.006 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2014 Feb 27;152(1):217-26. doi: 10.1016/j.jep.2014.01.006. Epub 
      2014 Jan 15.