PMID- 24440750
OWN - NLM
STAT- MEDLINE
DCOM- 20141031
LR  - 20191210
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 263
DP  - 2014 Mar 28
TI  - Elevated BDNF mRNA expression in the medial prefrontal cortex after d-amphetamine 
      reinstated conditioned place preference in rats.
PG  - 88-95
LID - S0306-4522(14)00026-8 [pii]
LID - 10.1016/j.neuroscience.2014.01.015 [doi]
AB  - Drug addiction behavior that is established and maintained by psychostimulants 
      has been shown to be associated with the expression of brain-derived neurotrophic 
      factor (BDNF) in the mesolimbic dopamine (DA) system. Cocaine has been used for 
      most prior studies testing this effect of psychostimulants and therefore 
      relatively little is known about its counterpart amphetamine (AMP). To fill this 
      gap, the present study was designed to test whether BDNF mRNA expression levels 
      in the DA terminal regions were changed specifically by d-AMP-induced conditioned 
      place preference (CPP) followed by drug-primed reinstatement. The dose of d-AMP, 
      1mg/kg, was confirmed to significantly induce CPP. Using this dose, a group of 
      rats was initially subjected to d-AMP CPP, which was followed by entry into an 
      extinction protocol with an additional 3-day withdrawal before a drug-primed 
      reinstatement test was carried out. Following extinction of d-AMP CPP, a lower 
      dose of d-AMP, namely 0.75mg/kg, was able to significantly reinstate CPP. The 
      BDNF mRNA levels in the selected brain areas were determined by real-time 
      polymerase chain reaction (PCR) after the CPP and reinstatement. The BDNF mRNA 
      level in the medial prefrontal cortex (mPFC) was significantly increased after 
      the reinstatement, but not the CPP test. And, none of the other four assessed 
      brain areas showed any change in BDNF mRNA level after d-AMP CPP or 
      reinstatement. These findings support the notion that BDNF is involved in 
      drug-seeking behavior and indicate that d-AMP reinstatement after extinction may 
      be linked to an increase in BDNF mRNA expression in the mPFC.
CI  - Copyright (c) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Shen, Y-L
AU  - Shen YL
AD  - Department of Psychology, National Cheng-Chi University, Taipei, Taiwan.
FAU - Chang, T-Y
AU  - Chang TY
AD  - Institute of Neuroscience, National Cheng-Chi University, Taipei, Taiwan.
FAU - Chang, Y-C
AU  - Chang YC
AD  - Department of Psychology, National Cheng-Chi University, Taipei, Taiwan.
FAU - Tien, H-H
AU  - Tien HH
AD  - Department of Psychology, National Cheng-Chi University, Taipei, Taiwan.
FAU - Yang, F-C
AU  - Yang FC
AD  - Department of Psychology, National Cheng-Chi University, Taipei, Taiwan.
FAU - Wang, P-Y
AU  - Wang PY
AD  - Institute of Neuroscience, National Cheng-Chi University, Taipei, Taiwan.
FAU - Liao, R-M
AU  - Liao RM
AD  - Department of Psychology, National Cheng-Chi University, Taipei, Taiwan; 
      Institute of Neuroscience, National Cheng-Chi University, Taipei, Taiwan; 
      Research Center for Mind, Brain and Learning, National Cheng-Chi University, 
      Taipei, Taiwan. Electronic address: rmliao@nccu.edu.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140115
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 0 (RNA, Messenger)
RN  - TZ47U051FI (Dextroamphetamine)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Conditioning, Psychological/*drug effects
MH  - Dextroamphetamine/*pharmacology
MH  - Dopamine Uptake Inhibitors/*pharmacology
MH  - Extinction, Psychological/drug effects
MH  - Male
MH  - Prefrontal Cortex/*drug effects/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - addiction
OT  - brain-derived neurotrophic factor
OT  - drug seeking
OT  - mesocorticolimbic dopamine
OT  - place conditioning
EDAT- 2014/01/21 06:00
MHDA- 2014/11/02 06:00
CRDT- 2014/01/21 06:00
PHST- 2013/12/17 00:00 [received]
PHST- 2014/01/08 00:00 [revised]
PHST- 2014/01/08 00:00 [accepted]
PHST- 2014/01/21 06:00 [entrez]
PHST- 2014/01/21 06:00 [pubmed]
PHST- 2014/11/02 06:00 [medline]
AID - S0306-4522(14)00026-8 [pii]
AID - 10.1016/j.neuroscience.2014.01.015 [doi]
PST - ppublish
SO  - Neuroscience. 2014 Mar 28;263:88-95. doi: 10.1016/j.neuroscience.2014.01.015. 
      Epub 2014 Jan 15.