PMID- 24442550
OWN - NLM
STAT- MEDLINE
DCOM- 20141106
LR  - 20211021
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Print)
IS  - 0364-3190 (Linking)
VI  - 39
IP  - 3
DP  - 2014
TI  - Metabolism changes during aging in the hippocampus and striatum of glud1 
      (glutamate dehydrogenase 1) transgenic mice.
PG  - 446-55
LID - 10.1007/s11064-014-1239-9 [doi]
AB  - The decline in neuronal function during aging may result from increases in 
      extracellular glutamate (Glu), Glu-induced neurotoxicity, and altered 
      mitochondrial metabolism. To study metabolic responses to persistently high 
      levels of Glu at synapses during aging, we used transgenic (Tg) mice that 
      over-express the enzyme Glu dehydrogenase (GDH) in brain neurons and release 
      excess Glu in synapses. Mitochondrial GDH is important in amino acid and 
      carbohydrate metabolism and in anaplerotic reactions. We monitored changes in 
      nineteen neurochemicals in the hippocampus and striatum of adult, middle aged, 
      and aged Tg and wild type (wt) mice, in vivo, using proton ((1)H) magnetic 
      resonance spectroscopy. Significant differences between adult Tg and wt were 
      higher Glu, N-acetyl aspartate (NAA), and NAA + NAA-Glu (NAAG) levels, and lower 
      lactate in the Tg hippocampus and striatum than those of wt. During aging, 
      consistent changes in Tg and wt hippocampus and striatum included increases in 
      myo-inositol and NAAG. The levels of glutamine (Gln), a key neurochemical in the 
      Gln-Glu cycle between neurons and astroglia, increased during aging in both the 
      striatum and hippocampus of Tg mice, but only in the striatum of the wt mice. 
      Age-related increases of Glu were observed only in the striatum of the Tg mice.
FAU - Choi, In-Young
AU  - Choi IY
AD  - Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, 
      KS, USA.
FAU - Lee, Phil
AU  - Lee P
FAU - Wang, Wen-Tung
AU  - Wang WT
FAU - Hui, Dongwei
AU  - Hui D
FAU - Wang, Xinkun
AU  - Wang X
FAU - Brooks, William M
AU  - Brooks WM
FAU - Michaelis, Elias K
AU  - Michaelis EK
LA  - eng
GR  - P30 AG035982/AG/NIA NIH HHS/United States
GR  - DK072171/DK/NIDDK NIH HHS/United States
GR  - DK53012/DK/NIDDK NIH HHS/United States
GR  - P01 AG012993/AG/NIA NIH HHS/United States
GR  - DK19525/DK/NIDDK NIH HHS/United States
GR  - P30 HD002528/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20140121
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Receptors, Glutamate)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 997-55-7 (N-acetylaspartate)
RN  - EC 1.4.1.2 (GluD1 protein, mouse)
RN  - EC 1.4.1.2 (Glutamate Dehydrogenase)
SB  - IM
MH  - *Aging
MH  - Animals
MH  - Aspartic Acid/analogs & derivatives/metabolism
MH  - Corpus Striatum/*metabolism
MH  - Glutamate Dehydrogenase
MH  - Glutamic Acid/metabolism
MH  - Hippocampus/*metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Neurons/metabolism
MH  - Receptors, Glutamate/genetics/*metabolism
MH  - Synapses/metabolism
PMC - PMC4095984
MID - NIHMS591806
EDAT- 2014/01/21 06:00
MHDA- 2014/11/07 06:00
PMCR- 2015/03/01
CRDT- 2014/01/21 06:00
PHST- 2013/10/10 00:00 [received]
PHST- 2014/01/08 00:00 [accepted]
PHST- 2014/01/03 00:00 [revised]
PHST- 2014/01/21 06:00 [entrez]
PHST- 2014/01/21 06:00 [pubmed]
PHST- 2014/11/07 06:00 [medline]
PHST- 2015/03/01 00:00 [pmc-release]
AID - 10.1007/s11064-014-1239-9 [doi]
PST - ppublish
SO  - Neurochem Res. 2014;39(3):446-55. doi: 10.1007/s11064-014-1239-9. Epub 2014 Jan 
      21.