PMID- 24444085
OWN - NLM
STAT- MEDLINE
DCOM- 20141124
LR  - 20160511
IS  - 1945-0257 (Electronic)
IS  - 1945-0257 (Linking)
VI  - 18
IP  - 4
DP  - 2014 Apr
TI  - Association between the g.14461A>G genetic polymorphism of the TLR4 gene and type 
      2 diabetes mellitus risk in a Chinese population.
PG  - 257-60
LID - 10.1089/gtmb.2013.0441 [doi]
AB  - OBJECTIVE: Toll-like receptor 4 (TLR4) is an important candidate gene for 
      mediating the susceptibility to type 2 diabetes mellitus (T2DM). The purpose of 
      this study was to investigate the association between the TLR4 gene polymorphisms 
      and T2DM susceptibility. METHODS: A total of 671 T2DM patients and 677 healthy 
      controls were recruited in this study. The created restriction site-polymerase 
      chain reaction and DNA sequencing methods have been used to analyze the TLR4 gene 
      polymorphisms. RESULTS: One novel genetic polymorphism (g.14461A>G) was found. 
      Our data indicated that the g.14461A>G genetic polymorphism was significantly 
      associated with the increased susceptibility to T2DM in a homozygote comparison 
      (GG vs. AA: odds ratio [OR]=2.09, 95% confidence interval [CI] 1.44-3.04, 
      p<0.001), dominant model (GG/AG vs. AA: OR=1.27, 95% CI 1.03-1.57, p=0.028), 
      recessive model (GG vs. AG/AA: OR=1.98, 95% CI 1.39-2.83, p<0.001), and allele 
      contrast (G vs. A: OR=1.33, 95% CI 1.13-1.57, p=0.001). The allele-G might be the 
      risk allele for enhancing the susceptibility to T2DM. CONCLUSION: These 
      preliminary findings suggest that the g.14461A>G genetic polymorphism of the TLR4 
      gene is potentially related to the susceptibility to T2DM in the studied 
      population.
FAU - Lei, Tao
AU  - Lei T
AD  - 1 Department of Endocrinology, Tongji Hospital, Tongji University School of 
      Medicine , Shanghai, People's Republic of China .
FAU - Tang, Wenjun
AU  - Tang W
FAU - Xiong, Yanqin
AU  - Xiong Y
FAU - Zhai, Yujuan
AU  - Zhai Y
FAU - Sun, Xianghua
AU  - Sun X
FAU - Zhang, Keqin
AU  - Zhang K
LA  - eng
PT  - Journal Article
DEP - 20140120
PL  - United States
TA  - Genet Test Mol Biomarkers
JT  - Genetic testing and molecular biomarkers
JID - 101494210
RN  - 0 (DNA Primers)
RN  - 0 (TLR4 protein, human)
RN  - 0 (Toll-Like Receptor 4)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Base Sequence
MH  - Case-Control Studies
MH  - China
MH  - DNA Primers
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Homozygote
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Toll-Like Receptor 4/*genetics
EDAT- 2014/01/22 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/01/22 06:00
PHST- 2014/01/22 06:00 [entrez]
PHST- 2014/01/22 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1089/gtmb.2013.0441 [doi]
PST - ppublish
SO  - Genet Test Mol Biomarkers. 2014 Apr;18(4):257-60. doi: 10.1089/gtmb.2013.0441. 
      Epub 2014 Jan 20.