PMID- 24445665
OWN - NLM
STAT- MEDLINE
DCOM- 20140319
LR  - 20220330
IS  - 1474-1741 (Electronic)
IS  - 1474-1733 (Linking)
VI  - 14
IP  - 2
DP  - 2014 Feb
TI  - The function of Fcgamma receptors in dendritic cells and macrophages.
PG  - 94-108
LID - 10.1038/nri3582 [doi]
AB  - Dendritic cells (DCs) and macrophages use various receptors to recognize foreign 
      antigens and to receive feedback control from adaptive immune cells. Although it 
      was long believed that all immunoglobulin Fc receptors are universally expressed 
      by phagocytes, recent findings indicate that only monocyte-derived DCs and 
      macrophages express high levels of activating Fc receptors for IgG (FcgammaRs), 
      whereas conventional and plasmacytoid DCs express the inhibitory FcgammaR. In this 
      Review, we discuss how the uptake, processing and presentation of antigens by DCs 
      and macrophages is influenced by FcgammaR recognition of immunoglobulins and immune 
      complexes in the steady state and during inflammation.
FAU - Guilliams, Martin
AU  - Guilliams M
AD  - 1] Laboratory of Immunoregulation, VIB Inflammation Research Center, 9052 Ghent, 
      Belgium. [2] Department of Respiratory Medicine, Ghent University, 9000 Ghent, 
      Belgium.
FAU - Bruhns, Pierre
AU  - Bruhns P
AD  - 1] Institut Pasteur, Departement d'Immunologie, Laboratoire Anticorps en Therapie 
      et Pathologie, 75015 Paris, France. [2] Institut National de la Sante et de la 
      Recherche Medicale, U760, 75015 Paris, France.
FAU - Saeys, Yvan
AU  - Saeys Y
AD  - 1] Laboratory of Immunoregulation, VIB Inflammation Research Center, 9052 Ghent, 
      Belgium. [2] Department of Respiratory Medicine, Ghent University, 9000 Ghent, 
      Belgium.
FAU - Hammad, Hamida
AU  - Hammad H
AD  - 1] Laboratory of Immunoregulation, VIB Inflammation Research Center, 9052 Ghent, 
      Belgium. [2] Department of Respiratory Medicine, Ghent University, 9000 Ghent, 
      Belgium.
FAU - Lambrecht, Bart N
AU  - Lambrecht BN
AD  - 1] Laboratory of Immunoregulation, VIB Inflammation Research Center, 9052 Ghent, 
      Belgium. [2] Department of Respiratory Medicine, Ghent University, 9000 Ghent, 
      Belgium. [3] Department of Pulmonary Medicine, Erasmus University Medical Center, 
      3015 Rotterdam, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140121
PL  - England
TA  - Nat Rev Immunol
JT  - Nature reviews. Immunology
JID - 101124169
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Fc)
RN  - 0 (Receptors, IgG)
SB  - IM
EIN - Nat Rev Immunol. 2014 May;14(5):349
MH  - Animals
MH  - Antigen Presentation
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Macrophages/*immunology
MH  - Phagocytes/immunology
MH  - RNA, Messenger/analysis
MH  - Receptors, Fc/*immunology
MH  - Receptors, IgG/genetics/*physiology
EDAT- 2014/01/22 06:00
MHDA- 2014/03/22 06:00
CRDT- 2014/01/22 06:00
PHST- 2014/01/22 06:00 [entrez]
PHST- 2014/01/22 06:00 [pubmed]
PHST- 2014/03/22 06:00 [medline]
AID - nri3582 [pii]
AID - 10.1038/nri3582 [doi]
PST - ppublish
SO  - Nat Rev Immunol. 2014 Feb;14(2):94-108. doi: 10.1038/nri3582. Epub 2014 Jan 21.