PMID- 24445989
OWN - NLM
STAT- MEDLINE
DCOM- 20140926
LR  - 20140203
IS  - 1869-1889 (Electronic)
IS  - 1674-7305 (Linking)
VI  - 57
IP  - 2
DP  - 2014 Feb
TI  - Collagen scaffolds modified with collagen-binding bFGF promotes the neural 
      regeneration in a rat hemisected spinal cord injury model.
PG  - 232-40
LID - 10.1007/s11427-014-4612-7 [doi]
AB  - Nerve conduit is one of strategies for spine cord injury (SCI) treatment. 
      Recently, studies showed that biomaterials could guide the neurite growth and 
      promote axon regeneration at the injury site. However, the scaffold by itself was 
      difficult to meet the need of SCI functional recovery. The basic fibroblast 
      growth factor (bFGF) administration significantly promotes functional recovery 
      after organ injuries. Here, using a rat model of T9 hemisected SCI, we aimed at 
      assessing the repair capacity of implantation of collagen scaffold (CS) modified 
      by collagen binding bFGF (CBD-bFGF). The results showed that CS combined with 
      CBD-bFGF treatment improved survival rates after the lateral hemisection SCI. The 
      CS/CBD-bFGF group showed more significant improvements in motor than the simply 
      CS-implanted and untreated control group, when evaluated by the 21-point 
      Basso-Beattie-Bresnahan (BBB) score and footprint analysis. Both hematoxylin and 
      eosin (H&E) and immunohistochemical staining of neurofilament (NF) and glial 
      fibrillary acidic protein (GFAP) demonstrated that fibers were guided to grow 
      through the implants. These findings indicated that administration of CS modified 
      with CBD-bFGF could promote spinal cord regeneration and functional recovery.
FAU - Shi, Qin
AU  - Shi Q
AD  - Orthopedic Department, the First Affiliated Hospital of Soochow University, 
      Suzhou, 215006, China.
FAU - Gao, Wei
AU  - Gao W
FAU - Han, XingLong
AU  - Han X
FAU - Zhu, XueSong
AU  - Zhu X
FAU - Sun, Jie
AU  - Sun J
FAU - Xie, Fang
AU  - Xie F
FAU - Hou, XiangLin
AU  - Hou X
FAU - Yang, HuiLin
AU  - Yang H
FAU - Dai, JianWu
AU  - Dai J
FAU - Chen, Liang
AU  - Chen L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140120
PL  - China
TA  - Sci China Life Sci
JT  - Science China. Life sciences
JID - 101529880
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Animals
MH  - Collagen/*metabolism
MH  - *Disease Models, Animal
MH  - Fibroblast Growth Factor 2/*metabolism
MH  - Male
MH  - *Nerve Regeneration
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spinal Cord Injuries/*physiopathology
MH  - *Tissue Scaffolds
EDAT- 2014/01/22 06:00
MHDA- 2014/09/27 06:00
CRDT- 2014/01/22 06:00
PHST- 2013/08/10 00:00 [received]
PHST- 2013/10/21 00:00 [accepted]
PHST- 2014/01/22 06:00 [entrez]
PHST- 2014/01/22 06:00 [pubmed]
PHST- 2014/09/27 06:00 [medline]
AID - 10.1007/s11427-014-4612-7 [doi]
PST - ppublish
SO  - Sci China Life Sci. 2014 Feb;57(2):232-40. doi: 10.1007/s11427-014-4612-7. Epub 
      2014 Jan 20.