PMID- 24446021
OWN - NLM
STAT- MEDLINE
DCOM- 20150420
LR  - 20211021
IS  - 1936-0568 (Electronic)
IS  - 1936-055X (Print)
IS  - 1936-055X (Linking)
VI  - 8
IP  - 3
DP  - 2014
TI  - Secretory myoepithelial carcinoma: a histologic and molecular survey and a 
      proposed nomenclature for mucin producing signet ring tumors.
PG  - 250-60
LID - 10.1007/s12105-014-0518-8 [doi]
AB  - Signet ring cell (mucin producing) adenocarcinoma is a rare low grade salivary 
      gland malignancy. While currently designated as an adenocarcinoma, myoepithelial 
      differentiation has been implied in previously reported cases. We herein perform 
      a survey of our cases of signet ring cell adenocarcinoma and review the 
      literature in order to refine categorization of this rare tumor. Five cases were 
      retrieved. One was reclassified as a mammary analogue secretory carcinoma, 
      leaving four that fulfilled the criteria for signet ring cell adenocarcinoma: the 
      presence of prominent signet ring or vacuolated cells arranged in islands, 
      interconnecting strands, cords or sheets in a myxoid or hyaline stroma, or pools 
      of mucin. An extensive panel of histochemical and immunohistochemical stains and 
      fluorescence in situ hybridization (FISH) (modeled after common phenotypes and 
      molecular alterations seen in signet ring and myoepithelial tumors at other 
      sites) was performed. The male-to-female ratio was 3:1. The mean age was 56 years 
      (range 18-81). Sites involved included buccal mucosa (2), soft palate (1) and 
      deep parotid (1). Perineural and angiolymphatic invasion were present in three 
      and two cases respectively. One patient was lost to follow up and the remainder 
      were alive and without disease at time of last follow up (mean 38 months). All 
      cases showed mucicarmine positive vacuolated/signet ring cells embedded in a 
      myxoid stroma. Three cases showed at least focal p63 staining and two cases 
      showed positivity for calponin. Membranous E-cadherin was retained in all cases. 
      FISH was negative for ETV6, EWSR1, and ALK1 rearrangements in all four cases. 
      Based on the current series and the previously reported cases, it is evident that 
      signet ring adenocarcinomas have a dual secretory and myoepithelial phenotype and 
      thus as a whole more appropriately designated as 'secretory myoepithelial 
      carcinoma.' They behave in a fairly indolent fashion and do not share the major 
      molecular alterations seen in other signet ring and myoepithelial tumor types.
FAU - Bastaki, Jassem M
AU  - Bastaki JM
AD  - Department of Histopathology, Sabah Hospital, Jamal Abdulnasir St., 3rd floor, 
      Kuwait, Kuwait, dr.bastaki@gmail.com.
FAU - Purgina, Bibianna M
AU  - Purgina BM
FAU - Dacic, Sanja
AU  - Dacic S
FAU - Seethala, Raja R
AU  - Seethala RR
LA  - eng
PT  - Journal Article
DEP - 20140121
PL  - United States
TA  - Head Neck Pathol
JT  - Head and neck pathology
JID - 101304010
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Mucins)
SB  - IM
MH  - Adolescent
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/analysis
MH  - Carcinoma, Signet Ring Cell/*classification/pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/*classification/pathology
MH  - Mucins/biosynthesis
MH  - Myoepithelioma/*classification/pathology
MH  - Phenotype
MH  - Terminology as Topic
PMC - PMC4126932
EDAT- 2014/01/22 06:00
MHDA- 2015/04/22 06:00
PMCR- 2015/01/21
CRDT- 2014/01/22 06:00
PHST- 2013/07/05 00:00 [received]
PHST- 2014/01/10 00:00 [accepted]
PHST- 2014/01/22 06:00 [entrez]
PHST- 2014/01/22 06:00 [pubmed]
PHST- 2015/04/22 06:00 [medline]
PHST- 2015/01/21 00:00 [pmc-release]
AID - 518 [pii]
AID - 10.1007/s12105-014-0518-8 [doi]
PST - ppublish
SO  - Head Neck Pathol. 2014;8(3):250-60. doi: 10.1007/s12105-014-0518-8. Epub 2014 Jan 
      21.