PMID- 24447245
OWN - NLM
STAT- MEDLINE
DCOM- 20141212
LR  - 20140417
IS  - 1944-0057 (Electronic)
IS  - 1944-0057 (Linking)
VI  - 31
IP  - 4
DP  - 2014 Apr
TI  - Evaluation of the migration of 15 photo-initiators from cardboard packaging into 
      Tenax((R)) using ultra-performance liquid chromatography-tandem mass spectrometry 
      (UPLC-MS/MS).
PG  - 767-75
LID - 10.1080/19440049.2014.886340 [doi]
AB  - Photo-initiators are widely used to cure ink on packaging materials used in food 
      applications such as plastic films or cartonboards. In migration studies, food 
      simulants are very often used to simulate food, like Tenax((R)), which is the 
      simulant for dry foodstuffs. In this paper a fast and reliable confirmation 
      method for the determination of the following photo-initiators in Tenax((R)) is 
      described: benzophenone (BP), 4,4'-bis(diethylamino)benzophenone (DEAB), 
      2-chloro-9H-thioxanthen-9-one (CTX), 1-chloro-4-propoxy-9H-thioxanthen-9-one 
      (CPTX), 2,4-diethyl-9H-thioxanthen-9-one (DETX), 2,2-dimethoxy-2-phenyl 
      acetophenone (DMPA), 4-(dimethylamino)benzophenone (DMBP), 2-ethylanthraquinone 
      (EA), ethyl-4-dimethylaminobenzoate (EDMAB), 1-hydroxylcyclohexyl phenyl ketone 
      (HCPK), 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone (HMMP), 
      2-isopropyl-9H-thioxanthen-9-one (ITX), 4-methylbenzophenone (MBP), Michler's 
      ketone (MK), and 4-phenylbenzophenone (PBZ). After the migration study was 
      completed, the simulant Tenax((R)) was extracted using acetonitrile, followed by 
      analysis on ultra-performance liquid chromatography-tandem mass spectrometry 
      (UPLC-MS/MS). Quantification was carried out using benzophenone-d10 (BP-d10) as 
      internal standard. The presented method is validated in terms of matrix effect, 
      specificity, linearity, recovery, precision and sensitivity, showing the method 
      can detect all photo-initiators at very low concentrations (LOD < 0.125 microg g(-1) 
      for all substances). Finally, the procedure was applied to real samples, proving 
      the capabilities of the presented method.
FAU - Van Den Houwe, K
AU  - Van Den Houwe K
AD  - a Department of Food, Medicines and Consumer Safety , Scientific Institute of 
      Public Health , Brussels , Belgium.
FAU - van de Velde, S
AU  - van de Velde S
FAU - Evrard, C
AU  - Evrard C
FAU - Van Hoeck, E
AU  - Van Hoeck E
FAU - Van Loco, J
AU  - Van Loco J
FAU - Bolle, F
AU  - Bolle F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140331
PL  - England
TA  - Food Addit Contam Part A Chem Anal Control Expo Risk Assess
JT  - Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & 
      risk assessment
JID - 101485040
RN  - 0 (Photosensitizing Agents)
SB  - IM
MH  - Chromatography, Liquid/*methods
MH  - Food Contamination/*analysis
MH  - *Food Packaging
MH  - Ink
MH  - Molecular Structure
MH  - Photosensitizing Agents
MH  - Reproducibility of Results
MH  - Tandem Mass Spectrometry/*methods
OTO - NOTNLM
OT  - Tenax(R)
OT  - food contact material
OT  - migration
OT  - paper and board
OT  - photo-initiators
OT  - tandem mass spectrometry
OT  - ultra-performance liquid chromatography
EDAT- 2014/01/23 06:00
MHDA- 2014/12/17 06:00
CRDT- 2014/01/23 06:00
PHST- 2014/01/23 06:00 [entrez]
PHST- 2014/01/23 06:00 [pubmed]
PHST- 2014/12/17 06:00 [medline]
AID - 10.1080/19440049.2014.886340 [doi]
PST - ppublish
SO  - Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014 
      Apr;31(4):767-75. doi: 10.1080/19440049.2014.886340. Epub 2014 Mar 31.