PMID- 24447572
OWN - NLM
STAT- MEDLINE
DCOM- 20141118
LR  - 20140314
IS  - 1532-3129 (Electronic)
IS  - 0021-9975 (Linking)
VI  - 150
IP  - 2-3
DP  - 2014 Feb-Apr
TI  - Comparative virulence of reproductive diseases caused by type 1 (European-like) 
      and type 2 (North American-like) porcine reproductive and respiratory syndrome 
      virus in experimentally infected pregnant gilts.
PG  - 297-305
LID - S0021-9975(13)00372-1 [pii]
LID - 10.1016/j.jcpa.2013.11.205 [doi]
AB  - The aim of this study was to compare the virulence of type 1 and type 2 porcine 
      reproductive and respiratory syndrome virus (PRRSV) as assessed by the level of 
      viral replication, viral distribution and apoptosis in stillborn fetuses and 
      live-born piglets from infected pregnant gilts. Type 1 or type 2 PRRSV was given 
      intranasally to pregnant gilts at 3 weeks before the expected date of 
      parturition. Regardless of virus genotype, PRRSV-infected gilts farrowed between 
      102 and 109 days of gestation, while control uninfected gilts carried the 
      pregnancy to term and farrowed at 114-115 days of gestation. There were no 
      significant differences in the mean number of virus-infected cells per unit area 
      of tissue when type 1 and type 2 virus infections were compared between stillborn 
      fetuses and live-born piglets. Stillborn fetuses from the type 1 PRRSV-infected 
      pregnant gilts had a significantly higher mean number of apoptotic cells per unit 
      area of thymus (P = 0.013) than those from type 2 PRRSV-infected pregnant gilts. 
      Significant differences in virulence were not observed between types 1 and 2 
      PRRSV in terms of female reproductive failure, although thymic apoptosis differed 
      in stillborn fetuses from type 1 and type 2 PRRSV-infected pregnant gilts.
CI  - Copyright (c) 2014. Published by Elsevier Ltd.
FAU - Han, K
AU  - Han K
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
FAU - Seo, H W
AU  - Seo HW
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
FAU - Park, C
AU  - Park C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
FAU - Kang, I
AU  - Kang I
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
FAU - Youn, S-K
AU  - Youn SK
AD  - Division of Epidemic Intelligence Service, Korea Centers for Diseases Control and 
      Prevention, Osong, Republic of Korea.
FAU - Lee, S Y
AU  - Lee SY
AD  - College of Oriental Medicine, Kyunghee University, 1 Hoegi-dong, Dongdaemun-ku, 
      130-701 Seoul, Republic of Korea.
FAU - Kim, S-H
AU  - Kim SH
AD  - College of Oriental Medicine, Kyunghee University, 1 Hoegi-dong, Dongdaemun-ku, 
      130-701 Seoul, Republic of Korea.
FAU - Chae, C
AU  - Chae C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea. 
      Electronic address: swine@snu.ac.kr.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131201
PL  - England
TA  - J Comp Pathol
JT  - Journal of comparative pathology
JID - 0102444
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Animals
MH  - DNA, Viral
MH  - Female
MH  - Genotype
MH  - Porcine Reproductive and Respiratory Syndrome/pathology/*virology
MH  - Porcine respiratory and reproductive syndrome virus/genetics/*pathogenicity
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/pathology/*veterinary/virology
MH  - Swine
MH  - Virulence
OTO - NOTNLM
OT  - pathogenicity
OT  - porcine reproductive and respiratory syndrome virus
OT  - reproductive failure
OT  - virulence
EDAT- 2014/01/23 06:00
MHDA- 2014/11/19 06:00
CRDT- 2014/01/23 06:00
PHST- 2013/08/14 00:00 [received]
PHST- 2013/09/16 00:00 [revised]
PHST- 2013/11/20 00:00 [accepted]
PHST- 2014/01/23 06:00 [entrez]
PHST- 2014/01/23 06:00 [pubmed]
PHST- 2014/11/19 06:00 [medline]
AID - S0021-9975(13)00372-1 [pii]
AID - 10.1016/j.jcpa.2013.11.205 [doi]
PST - ppublish
SO  - J Comp Pathol. 2014 Feb-Apr;150(2-3):297-305. doi: 10.1016/j.jcpa.2013.11.205. 
      Epub 2013 Dec 1.