PMID- 24449336
OWN - NLM
STAT- MEDLINE
DCOM- 20141212
LR  - 20211021
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 30
IP  - 3
DP  - 2014 Mar
TI  - A fast and effective method to assess myocardial hyperemia in acute myocarditis 
      by magnetic resonance.
PG  - 629-37
LID - 10.1007/s10554-014-0371-6 [doi]
AB  - Current cardiac magnetic resonance (CMR) quantitative signs for the diagnosis of 
      myocarditis include myocardial edema, fibrosis and myocardial hyperemia (Hyp). 
      Methods for the assessment of Hyp are actually complex and time-consuming. To 
      test a simple and fast method to assess Hyp, using contrast enhancement steady 
      state free precession (ceSSFP) technique. CMR imaging at 1.5T was performed on 39 
      patients with diagnosis of acute myocarditis and in 20 healthy controls. Hyp was 
      evaluated in systolic and diastolic frames (Hyp-SYS and Hyp-DIA) as areas of 
      myocardial hyperintensity in ceSSFP images early after gadolinium injection. 
      Myocardial edema was evaluated using T2-STIR images. Myocardial fibrosis was 
      assessed in conventional late gadolinium enhancement (LGE) images. A value of 
      </=12.1 g of Hyp-DIA was obtained as cut-off of normality in healthy controls. 
      Using this threshold, Hyp was detected in 30 patients (77 %) with myocarditis. 
      LGE was detected in 36 patients (92 %), and myocardial edema in 38 (97 %) 
      patients with myocarditis A linear relation was found between Hyp-DIA and the 
      extent of myocardial edema (R(2) 0.48, 95 % CI 0.47-0.85, p < 0.001) and the 
      extent of LGE (R(2) 0.41, 95 % CI 0.31-0.61, p < 0.001). Patients with hyperemia 
      had higher levels of C-reactive protein (p < 0.001), a higher extent of LGE (p < 
      0.05) and a larger left atrial area (p < 0.05). ceSSFP sequence at CMR is a novel 
      and fast method to assess myocardial hyperemia in patient with acute myocarditis. 
      Compared with non-Hyp subjects, patients with Hyp had more signs of inflammation 
      and myocardial damage.
FAU - Perfetti, Matteo
AU  - Perfetti M
AD  - Institute of Cardiology, "G. d'Annunzio" University, Chieti, Pescara, Italy.
FAU - Malatesta, Gelsomina
AU  - Malatesta G
FAU - Alvarez, Irene
AU  - Alvarez I
FAU - Liga, Riccardo
AU  - Liga R
FAU - Barison, Andrea
AU  - Barison A
FAU - Todiere, Giancarlo
AU  - Todiere G
FAU - Eletto, Nicoletta
AU  - Eletto N
FAU - De Caterina, Raffaele
AU  - De Caterina R
FAU - Lombardi, Massimo
AU  - Lombardi M
FAU - Aquaro, Giovanni Donato
AU  - Aquaro GD
LA  - eng
PT  - Journal Article
DEP - 20140122
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Contrast Media
MH  - Edema, Cardiac/complications/diagnosis
MH  - Feasibility Studies
MH  - Female
MH  - Fibrosis/complications/diagnosis
MH  - Gadolinium DTPA
MH  - Humans
MH  - Hyperemia/complications/*diagnosis
MH  - Image Enhancement/methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Myocarditis/complications/*diagnosis
MH  - Myocardium/*pathology
MH  - Reproducibility of Results
EDAT- 2014/01/23 06:00
MHDA- 2014/12/17 06:00
CRDT- 2014/01/23 06:00
PHST- 2013/09/03 00:00 [received]
PHST- 2014/01/15 00:00 [accepted]
PHST- 2014/01/23 06:00 [entrez]
PHST- 2014/01/23 06:00 [pubmed]
PHST- 2014/12/17 06:00 [medline]
AID - 10.1007/s10554-014-0371-6 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2014 Mar;30(3):629-37. doi: 10.1007/s10554-014-0371-6. 
      Epub 2014 Jan 22.