PMID- 24449369
OWN - NLM
STAT- MEDLINE
DCOM- 20150105
LR  - 20211021
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 41
IP  - 5
DP  - 2014 May
TI  - SLC30A8 gene polymorphism (rs13266634 C/T) and type 2 diabetes mellitus in south 
      Iranian population.
PG  - 2709-15
LID - 10.1007/s11033-014-3158-x [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disorder which is 
      characterized by chronic hyperglycemia. T2DM is due to the interplay of genetic 
      susceptibility and environmental factors. Zinc is an important element for 
      insulin storage and secretion. Zinc transporters ensure zinc transportation 
      across the biological membranes and enable the cellular flow of zinc into the 
      extracellular matrix or the intracellular vesicles. Solute carrier family 30 
      member 8 (SLC30A8) gene encodes zinc transporter protein member 8. The rs13266634 
      C/T polymorphism in SLC30A8 gene has been reported with higher risk of T2DM in 
      literature. Thus, the present study aimed to investigate the association between 
      rs13266634 polymorphism and T2DM in Fars province, Southern Iran and compare the 
      results with other populations. A total of 306 subjects were collected from the 
      outpatients of Shahid Motahhari clinic affiliated to Shiraz University of Medical 
      Sciences, Shiraz, Iran. These subjects were genotyped using polymerase chain 
      reaction-restriction fragment length polymorphism and validated by direct 
      sequencing. The frequency of CC genotype in diabetic and control groups was 90 
      (59.6%) and 89 (57.4%). The number of CT genotype was 51 (33.8%) in the case and 
      49 (31.6%) in the control group. The TT genotype was 10 (6.6%) and 17 (11%) in 
      diabetic and non-diabetic subjects, respectively. No significant difference was 
      found between the normal and T2DM subjects regarding the allelic and genotypic 
      distribution (p=0.35, OR=1.19, 95% CI 0.82-1.7) and (p=0.94, OR=1.7, 95% CI 
      0.7-3.9). No significant difference was found between the normal and diabetic 
      subjects regarding the rs13266634 C/T polymorphism in SLC30A8 gene. In comparison 
      with other ethnic groups, the C allele frequency in our population was very 
      similar to that of the European but higher than that of the Eastern Asian and 
      lower than the African populations.
FAU - Faghih, Hossein
AU  - Faghih H
AD  - Department of Genetic, Faculty of Science, Shahid Chamran University of Ahwaz, 
      Ahwaz, Iran.
FAU - Khatami, Saied-Reza
AU  - Khatami SR
FAU - Azarpira, Negar
AU  - Azarpira N
FAU - Foroughmand, Ali-Mohammad
AU  - Foroughmand AM
LA  - eng
PT  - Journal Article
DEP - 20140122
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (Cation Transport Proteins)
RN  - 0 (SLC30A8 protein, human)
RN  - 0 (Zinc Transporter 8)
SB  - IM
MH  - Aged
MH  - *Alleles
MH  - Case-Control Studies
MH  - Cation Transport Proteins/*genetics
MH  - Diabetes Mellitus, Type 2/genetics
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Iran
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Zinc Transporter 8
EDAT- 2014/01/23 06:00
MHDA- 2015/01/06 06:00
CRDT- 2014/01/23 06:00
PHST- 2013/05/13 00:00 [received]
PHST- 2014/01/13 00:00 [accepted]
PHST- 2014/01/23 06:00 [entrez]
PHST- 2014/01/23 06:00 [pubmed]
PHST- 2015/01/06 06:00 [medline]
AID - 10.1007/s11033-014-3158-x [doi]
PST - ppublish
SO  - Mol Biol Rep. 2014 May;41(5):2709-15. doi: 10.1007/s11033-014-3158-x. Epub 2014 
      Jan 22.