PMID- 24449482
OWN - NLM
STAT- MEDLINE
DCOM- 20141113
LR  - 20160511
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 4
IP  - 4
DP  - 2014 Apr
TI  - Markers of disease severity and socioeconomic factors in allergic fungal 
      rhinosinusitis.
PG  - 272-9
LID - 10.1002/alr.21292 [doi]
AB  - BACKGROUND: Allergic fungal rhinosinusitis (AFRS) is a refractory subtype of 
      chronic rhinosinusitis. There is a paucity of data investigating the association 
      of epidemiologic markers of disease severity. The primary objective of this study 
      is to evaluate components of disease severity with socioeconomic status and 
      health care access. METHODS: A retrospective analysis was performed on patients 
      diagnosed with AFRS by Bent and Kuhn criteria from 2000 to 2013. Severity of 
      disease was measured by orbitocranial involvement, bone erosion, Lund-Mackay 
      score, serum immunoglobulin E (IgE), and mold hypersensitivity. The North 
      Carolina State Data Center provided county-specific socioeconomic and demographic 
      data. Fisher's exact test, Wilcoxon rank sum test, Pearson correlations, and 
      multivariable linear regression models were used to explore associations between 
      variables. RESULTS: Of 93 patients, 58% were African American and 39% Caucasian 
      with a male:female ratio of 1.4:1 and average age at presentation of 29 years. 
      Race, age, insurance status, and gender were not associated with severity of 
      disease. Bone erosion was correlated with residence in counties with lower income 
      per capita (p = 0.01). Patients with orbitocranial involvement resided in more 
      rural counties (p = 0.01) with less primary care providers per capita (p = 0.02). 
      Residence in counties with older or poorer quality housing was associated with a 
      higher prevalence of bone erosion (p = 0.02). CONCLUSION: Within our cohort of 
      patients residing in North Carolina, markers of disease severity (bone erosion 
      and orbitocranial involvement) in AFRS were associated with lower income, rural 
      counties, poor housing quality, and less health care access.
CI  - (c) 2014 ARS-AAOA, LLC.
FAU - Miller, Justin D
AU  - Miller JD
AD  - Department of Otolaryngology-Head and Neck Surgery, University of North Carolina, 
      Chapel Hill, NC.
FAU - Deal, Allison M
AU  - Deal AM
FAU - McKinney, Kibwei A
AU  - McKinney KA
FAU - McClurg, Stanley W
AU  - McClurg SW
FAU - Rodriguez, Kenneth D
AU  - Rodriguez KD
FAU - Thorp, Brian D
AU  - Thorp BD
FAU - Senior, Brent A
AU  - Senior BA
FAU - Zanation, Adam M
AU  - Zanation AM
FAU - Ebert, Charles S Jr
AU  - Ebert CS Jr
LA  - eng
PT  - Journal Article
DEP - 20140121
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Bone and Bones/pathology
MH  - Child
MH  - Female
MH  - Health Services Accessibility
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Middle Aged
MH  - Mycoses/blood/diagnosis/*epidemiology
MH  - North Carolina/epidemiology
MH  - Rhinitis, Allergic
MH  - Rhinitis, Allergic, Perennial/blood/diagnosis/*epidemiology
MH  - Rural Population
MH  - Severity of Illness Index
MH  - Sinusitis/blood/diagnosis/*epidemiology
MH  - Socioeconomic Factors
MH  - Young Adult
OTO - NOTNLM
OT  - allergy
OT  - bone
OT  - chronic rhinosinusitis
OT  - demography
OT  - epidemiology
OT  - gender
OT  - mold
OT  - race
OT  - sinusitis
EDAT- 2014/01/23 06:00
MHDA- 2014/11/14 06:00
CRDT- 2014/01/23 06:00
PHST- 2013/08/14 00:00 [received]
PHST- 2013/11/07 00:00 [revised]
PHST- 2013/11/26 00:00 [accepted]
PHST- 2014/01/23 06:00 [entrez]
PHST- 2014/01/23 06:00 [pubmed]
PHST- 2014/11/14 06:00 [medline]
AID - 10.1002/alr.21292 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2014 Apr;4(4):272-9. doi: 10.1002/alr.21292. Epub 2014 
      Jan 21.