PMID- 24450939
OWN - NLM
STAT- MEDLINE
DCOM- 20140911
LR  - 20211021
IS  - 1471-230X (Electronic)
IS  - 1471-230X (Linking)
VI  - 14
DP  - 2014 Jan 22
TI  - Is the reflux disease questionnaire useful for identifying GERD according to the 
      Montreal definition?
PG  - 17
LID - 10.1186/1471-230X-14-17 [doi]
AB  - BACKGROUND: Scales for aiding physicians diagnose gastro-oesophageal reflux 
      disease (GERD) have not been evaluated in terms of their ability to discriminate 
      between troublesome symptoms (TS) and non-troublesome symptoms (NTS). Our 
      objective is to evaluate the ability of the Reflux Disease Questionnaire (RDQ) to 
      identify GERD according to referral of TS, in patients without previous proton 
      pump inhibitor (PPI) treatment and in patients on PPI treatment. METHODS: 
      Patients consulting physicians because of heartburn or acid regurgitation were 
      recruited at 926 primary-care centres in Spain. They were asked to complete 
      several questionnaires including the RDQ, and to define which of their symptoms 
      were troublesome. Information on drug treatment was collected by the physician. 
      We performed a receiver operating characteristic (ROC) curve analysis to 
      ascertain the RDQ's optimum cut-point for identifying TS. RESULTS: 4574 patients 
      were included, 1887 without PPI and 2596 on PPI treatment. Among those without 
      PPI treatment, 1722 reported TS. The area under the curve (AUC) was 0.79 for the 
      RDQ, and the optimum RDQ cut-point for identifying TS was 3.18 (sensitivity, 
      63.2%; specificity, 80.2%). A total of 2367 patients on PPI treatment reported 
      TS, and the optimum RDQ cut-off value was 3.06 (sensitivity, 65.4%; specificity, 
      71.8%). CONCLUSIONS: An RDQ score higher than 3 shows good sensitivity and 
      specificity for differentiating TS from NTS among patients without PPI or on PPI 
      treatment. The RDQ is useful in primary care for diagnosis of GERD based on the 
      Montreal definition.
FAU - Rey, Enrique
AU  - Rey E
FAU - Barcelo, Marta
AU  - Barcelo M
AD  - Department of Digestive Diseases, San Carlos Clinical Hospital, Madrid 
      Complutense University, Madrid 28040, Spain. marta.barcelo@yahoo.es.
FAU - Zapardiel, Javier
AU  - Zapardiel J
FAU - Sobreviela, Eduardo
AU  - Sobreviela E
FAU - Munoz, Mercedes
AU  - Munoz M
FAU - Diaz-Rubio, Manuel
AU  - Diaz-Rubio M
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20140122
PL  - England
TA  - BMC Gastroenterol
JT  - BMC gastroenterology
JID - 100968547
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Area Under Curve
MH  - Cross-Sectional Studies
MH  - Female
MH  - Gastroesophageal Reflux/complications/*diagnosis/drug therapy
MH  - Heartburn/etiology
MH  - Humans
MH  - Laryngopharyngeal Reflux/etiology
MH  - Male
MH  - Middle Aged
MH  - Proton Pump Inhibitors
MH  - ROC Curve
MH  - Spain
MH  - *Surveys and Questionnaires
PMC - PMC3976092
EDAT- 2014/01/24 06:00
MHDA- 2014/09/12 06:00
PMCR- 2014/01/22
CRDT- 2014/01/24 06:00
PHST- 2013/10/06 00:00 [received]
PHST- 2013/12/30 00:00 [accepted]
PHST- 2014/01/24 06:00 [entrez]
PHST- 2014/01/24 06:00 [pubmed]
PHST- 2014/09/12 06:00 [medline]
PHST- 2014/01/22 00:00 [pmc-release]
AID - 1471-230X-14-17 [pii]
AID - 10.1186/1471-230X-14-17 [doi]
PST - epublish
SO  - BMC Gastroenterol. 2014 Jan 22;14:17. doi: 10.1186/1471-230X-14-17.