PMID- 24451847
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20211021
IS  - 1873-2941 (Electronic)
IS  - 0009-3084 (Print)
IS  - 0009-3084 (Linking)
VI  - 182
DP  - 2014 Sep
TI  - Interplay between phosphoinositide lipids and calcium signals at the leading edge 
      of chemotaxing ameboid cells.
PG  - 73-9
LID - S0009-3084(14)00003-6 [pii]
LID - 10.1016/j.chemphyslip.2014.01.002 [doi]
AB  - The chemotactic migration of eukaryotic ameboid cells up concentration gradients 
      is among the most advanced forms of cellular behavior. Chemotaxis is controlled 
      by a complex network of signaling proteins bound to specific lipids on the 
      cytoplasmic surface of the plasma membrane at the front of the cell, or the 
      leading edge. The central lipid players in this leading edge signaling pathway 
      include the phosphoinositides PI(4,5)P2 (PIP2) and PI(3,4,5)P3 (PIP3), both of 
      which play multiple roles. The products of PI(4,5)P2 hydrolysis, diacylglycerol 
      (DAG) and Ins(1,4,5)P3 (IP3), are also implicated as important players. Together, 
      these leading edge phosphoinositides and their degradation products, in concert 
      with a local Ca(2+) signal, control the recruitment and activities of many 
      peripheral membrane proteins that are crucial to the leading edge signaling 
      network. The present critical review summarizes the current molecular 
      understanding of chemotactic signaling at the leading edge, including newly 
      discovered roles of phosphoinositide lipids and Ca(2+), while highlighting key 
      questions for future research.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Falke, Joseph J
AU  - Falke JJ
AD  - Department of Chemistry and Biochemistry and Molecular Biophysics Program, 
      University of Colorado, Boulder, CO 80309-0596, USA. Electronic address: 
      falke@colorado.edu.
FAU - Ziemba, Brian P
AU  - Ziemba BP
AD  - Department of Chemistry and Biochemistry and Molecular Biophysics Program, 
      University of Colorado, Boulder, CO 80309-0596, USA.
LA  - eng
GR  - R01 GM063235/GM/NIGMS NIH HHS/United States
GR  - R01 GM-063235/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20140119
PL  - Ireland
TA  - Chem Phys Lipids
JT  - Chemistry and physics of lipids
JID - 0067206
RN  - 0 (Phosphatidylinositols)
SB  - IM
MH  - *Calcium Signaling
MH  - *Chemotaxis
MH  - Eukaryotic Cells/*cytology/*metabolism
MH  - Humans
MH  - Phosphatidylinositols/chemistry/*metabolism
PMC - PMC4104151
MID - NIHMS567343
OTO - NOTNLM
OT  - C2 domain
OT  - PDK1
OT  - PH domain
OT  - PI3K
OT  - PKC
OT  - Phosphatidylinositol lipid
EDAT- 2014/01/24 06:00
MHDA- 2015/03/31 06:00
PMCR- 2015/09/01
CRDT- 2014/01/24 06:00
PHST- 2013/10/15 00:00 [received]
PHST- 2013/12/09 00:00 [revised]
PHST- 2014/01/08 00:00 [accepted]
PHST- 2014/01/24 06:00 [entrez]
PHST- 2014/01/24 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - S0009-3084(14)00003-6 [pii]
AID - 10.1016/j.chemphyslip.2014.01.002 [doi]
PST - ppublish
SO  - Chem Phys Lipids. 2014 Sep;182:73-9. doi: 10.1016/j.chemphyslip.2014.01.002. Epub 
      2014 Jan 19.