PMID- 24452882
OWN - NLM
STAT- MEDLINE
DCOM- 20180123
LR  - 20180325
IS  - 1530-8022 (Electronic)
IS  - 0885-3282 (Linking)
VI  - 29
IP  - 1
DP  - 2014 Jul
TI  - In vitro osteogenic cell proliferation, mineralization, and in vivo 
      osseointegration of injection molded high-density polyethylene-based hybrid 
      composites in rabbit animal model.
PG  - 142-57
LID - 10.1177/0885328214520805 [doi]
AB  - The present work reports the biocompatibility property of injection molded 
      HDPE-HA-Al2O3 hybrid composites. In vitro cytocompatibility results reveal that 
      osteogenic cell viability and bone mineralization are favorably supported in a 
      statistically significant manner on HDPE-20% HA-20% Al2O3 composite, in 
      comparison to HDPE-40 wt.% HA or HDPE-40 wt.% Al2O3 The difference in 
      cytocompatibility property is explained in terms of difference in substrate 
      wettability/surface energy and importantly, both the cell proliferation at 7 days 
      or bone mineralization at 21 days on HDPE-20% HA-20% Al2O3 composite are either 
      comparable or better than sintered HA. The progressive healing of cylindrical 
      femoral bone defects in rabbit animal model was assessed by implantation 
      experiments over 1, 4 and 12 weeks. Based on the histological analysis as well as 
      histomorphometrical evaluation, a better efficacy of HDPE-20% HA-20% Al2O3 over 
      high-density polyethylene (HDPE) for bone regeneration and neobone formation at 
      host bone-implant interface was established. Taken together, the present study 
      unequivocally establishes that despite the presence of 20% Al2O3, HDPE-based 
      hybrid composites are as biocompatible as HA in vitro or better than HDPE 
      in vivo.
CI  - (c) The Author(s) 2014 Reprints and permissions: 
      sagepub.co.uk/journalsPermissions.nav.
FAU - Tripathi, Garima
AU  - Tripathi G
AD  - Department of Materials Science and Engineering, Indian Institute of Technology 
      Kanpur, Kanpur, India.
FAU - Basu, Bikramjit
AU  - Basu B
AD  - Laboratory for Biomaterials, Materials Research Centre, Indian Institute of 
      Science, Bangalore, India bikram@mrc.iisc.ernet.in.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140122
PL  - England
TA  - J Biomater Appl
JT  - Journal of biomaterials applications
JID - 8813912
RN  - 0 (Biocompatible Materials)
RN  - 0 (Bone Substitutes)
RN  - 9002-88-4 (Polyethylene)
RN  - 91D9GV0Z28 (Durapatite)
RN  - LMI26O6933 (Aluminum Oxide)
SB  - IM
MH  - Aluminum Oxide/chemistry
MH  - Animals
MH  - Biocompatible Materials/chemistry
MH  - Bone Substitutes/*chemistry
MH  - Calcification, Physiologic
MH  - Cell Adhesion
MH  - Cell Proliferation
MH  - Cell Survival
MH  - Durapatite/chemistry
MH  - *Implants, Experimental
MH  - In Vitro Techniques
MH  - Materials Testing
MH  - *Osseointegration
MH  - Osteoblasts/cytology
MH  - *Osteogenesis
MH  - Polyethylene/chemistry
MH  - Rabbits
OTO - NOTNLM
OT  - Surface property
OT  - cell adhesion
OT  - histopathology
OT  - in vivo implantation
EDAT- 2014/01/24 06:00
MHDA- 2014/01/24 06:01
CRDT- 2014/01/24 06:00
PHST- 2014/01/24 06:00 [entrez]
PHST- 2014/01/24 06:00 [pubmed]
PHST- 2014/01/24 06:01 [medline]
AID - 0885328214520805 [pii]
AID - 10.1177/0885328214520805 [doi]
PST - ppublish
SO  - J Biomater Appl. 2014 Jul;29(1):142-57. doi: 10.1177/0885328214520805. Epub 2014 
      Jan 22.