PMID- 24453844
OWN - NLM
STAT- MEDLINE
DCOM- 20140616
LR  - 20221207
IS  - 1537-744X (Electronic)
IS  - 2356-6140 (Print)
IS  - 1537-744X (Linking)
VI  - 2013
DP  - 2013
TI  - Raised serum adenosine deaminase level in nonobese type 2 diabetes mellitus.
PG  - 404320
LID - 10.1155/2013/404320 [doi]
LID - 404320
AB  - The role of inflammation being minimal in the pathogenesis of type 2 diabetes 
      mellitus (T2DM) in nonobese patients; the aim of the study was to investigate the 
      role of adenosine deaminase (ADA) and see its association with diabetes mellitus. 
      The preliminary case control study comprised of 56 cases and 45 healthy controls 
      which were age and sex matched. 3 mL venous blood samples were obtained from the 
      patients as well as controls after 8-10 hours of fasting. Serum ADA and routine 
      biochemical parameters were analyzed. Serum ADA level was found significantly 
      higher among nonobese T2DM subjects with respect to controls (38.77 +/- 14.29 
      versus 17.02 +/- 5.74 U/L; P < 0.0001). Serum ADA level showed a significant 
      positive correlation with fasting plasma glucose (r = 0.657; P < 0.0001) level 
      among nonobese T2DM subjects, but no significant correlation was observed in 
      controls (r = -0.203; P = 0.180). However, no correlation was observed between 
      serum ADA level compared to BMI and HbA1c levels. Our study shows higher serum 
      ADA, triglycerides (TG) and fasting plasma glucose (FPG) levels in nonobese T2DM 
      patients, and a strong correlation between ADA and FPG which suggests an 
      association between ADA and nonobese T2DM subjects.
FAU - Khemka, Vineet Kumar
AU  - Khemka VK
AD  - Department of Biochemistry, Institute of Post Graduate Medical Education and 
      Research, 244 A J C Bose Road, Kolkata 700020, India.
FAU - Bagchi, Debajit
AU  - Bagchi D
AD  - Department of Biochemistry, Institute of Post Graduate Medical Education and 
      Research, 244 A J C Bose Road, Kolkata 700020, India.
FAU - Ghosh, Arindam
AU  - Ghosh A
AD  - Department of Biochemistry, Institute of Post Graduate Medical Education and 
      Research, 244 A J C Bose Road, Kolkata 700020, India.
FAU - Sen, Oishimaya
AU  - Sen O
AD  - Department of Biochemistry, Institute of Post Graduate Medical Education and 
      Research, 244 A J C Bose Road, Kolkata 700020, India.
FAU - Bir, Aritri
AU  - Bir A
AD  - Department of Biochemistry, Institute of Post Graduate Medical Education and 
      Research, 244 A J C Bose Road, Kolkata 700020, India.
FAU - Chakrabarti, Sasanka
AU  - Chakrabarti S
AD  - Department of Biochemistry, Institute of Post Graduate Medical Education and 
      Research, 244 A J C Bose Road, Kolkata 700020, India.
FAU - Banerjee, Anindita
AU  - Banerjee A
AD  - Department of Biochemistry, Institute of Post Graduate Medical Education and 
      Research, 244 A J C Bose Road, Kolkata 700020, India.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131225
PL  - United States
TA  - ScientificWorldJournal
JT  - TheScientificWorldJournal
JID - 101131163
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Triglycerides)
RN  - 0 (hemoglobin A1c protein, human)
RN  - EC 3.5.4.4 (Adenosine Deaminase)
SB  - IM
MH  - Adenosine Deaminase/*blood
MH  - Blood Glucose/metabolism
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/blood/*enzymology
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Statistics, Nonparametric
MH  - Triglycerides/blood
PMC - PMC3886277
EDAT- 2014/01/24 06:00
MHDA- 2014/06/17 06:00
PMCR- 2013/12/25
CRDT- 2014/01/24 06:00
PHST- 2013/08/18 00:00 [received]
PHST- 2013/09/27 00:00 [accepted]
PHST- 2014/01/24 06:00 [entrez]
PHST- 2014/01/24 06:00 [pubmed]
PHST- 2014/06/17 06:00 [medline]
PHST- 2013/12/25 00:00 [pmc-release]
AID - 10.1155/2013/404320 [doi]
PST - epublish
SO  - ScientificWorldJournal. 2013 Dec 25;2013:404320. doi: 10.1155/2013/404320. 
      eCollection 2013.