PMID- 24454680
OWN - NLM
STAT- MEDLINE
DCOM- 20140917
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 1
DP  - 2014
TI  - Exposure to perfluorooctane sulfonate in utero reduces testosterone production in 
      rat fetal Leydig cells.
PG  - e78888
LID - 10.1371/journal.pone.0078888 [doi]
LID - e78888
AB  - BACKGROUND: Perfluorooctane sulfonate (PFOS) is a synthetic material that has 
      been widely used in industrial applications for decades. Exposure to PFOS has 
      been associated with decreased adult testosterone level, and Leydig cell 
      impairment during the time of adulthood. However, little is known about PFOS 
      effects in utero on fetal Leydig cells (FLC). METHODS AND RESULTS: The present 
      study investigated effects of PFOS on FLC function. Pregnant Sprague Dawley 
      female rats received vehicle (0.05% Tween20) or PFOS (5, 20 mg/kg) by oral gavage 
      from gestational day (GD) 11-19. At GD20, testosterone (T) production, FLC 
      numbers and ultrastructure, testicular gene and protein expression levels were 
      examined. The results indicate that exposures to PFOS have affected FLC function 
      as evidenced by decreased T production, impaired FLC, reduced FLC number, and 
      decreased steroidogenic capacity and cholesterol level in utero. CONCLUSION: The 
      present study shows that PFOS is an endocrine disruptor of male reproductive 
      system as it causes reduction of T production and impairment of rat fetal Leydig 
      cells.
FAU - Zhao, Binghai
AU  - Zhao B
AD  - Heilongjiang Key Laboratory of Anti-fibrosis Biotherapy, Heilongjiang, P. R. 
      China.
FAU - Li, Li
AU  - Li L
AD  - Heilongjiang Key Laboratory of Anti-fibrosis Biotherapy, Heilongjiang, P. R. 
      China.
FAU - Liu, Jieting
AU  - Liu J
AD  - Heilongjiang Key Laboratory of Anti-fibrosis Biotherapy, Heilongjiang, P. R. 
      China.
FAU - Li, Hongzhi
AU  - Li H
AD  - Heilongjiang Key Laboratory of Anti-fibrosis Biotherapy, Heilongjiang, P. R. 
      China.
FAU - Zhang, Chunlei
AU  - Zhang C
AD  - Heilongjiang Key Laboratory of Anti-fibrosis Biotherapy, Heilongjiang, P. R. 
      China.
FAU - Han, Pengfei
AU  - Han P
AD  - Hong Qi Hospital, Mudanjiang Medical University, Heilongjiang, P. R. China.
FAU - Zhang, Yufei
AU  - Zhang Y
AD  - Heilongjiang Key Laboratory of Anti-fibrosis Biotherapy, Heilongjiang, P. R. 
      China.
FAU - Yuan, Xiaohuan
AU  - Yuan X
AD  - Heilongjiang Key Laboratory of Anti-fibrosis Biotherapy, Heilongjiang, P. R. 
      China.
FAU - Ge, Ren Shan
AU  - Ge RS
AD  - The 2nd Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 
      China.
FAU - Chu, Yanhui
AU  - Chu Y
AD  - Heilongjiang Key Laboratory of Anti-fibrosis Biotherapy, Heilongjiang, P. R. 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140114
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Fluorocarbons)
RN  - 3XMK78S47O (Testosterone)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
SB  - IM
MH  - Alkanesulfonic Acids/*toxicity
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Cell Count
MH  - Cell Size/drug effects
MH  - Cholesterol/metabolism
MH  - Female
MH  - Fetus/*cytology/*drug effects/physiology
MH  - Fluorocarbons/*toxicity
MH  - Gene Expression Regulation/drug effects
MH  - Leydig Cells/drug effects
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reproduction/drug effects
MH  - Testosterone/*biosynthesis
PMC - PMC3891643
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/01/24 06:00
MHDA- 2014/09/18 06:00
PMCR- 2014/01/14
CRDT- 2014/01/24 06:00
PHST- 2013/02/27 00:00 [received]
PHST- 2013/09/17 00:00 [accepted]
PHST- 2014/01/24 06:00 [entrez]
PHST- 2014/01/24 06:00 [pubmed]
PHST- 2014/09/18 06:00 [medline]
PHST- 2014/01/14 00:00 [pmc-release]
AID - PONE-D-13-08617 [pii]
AID - 10.1371/journal.pone.0078888 [doi]
PST - epublish
SO  - PLoS One. 2014 Jan 14;9(1):e78888. doi: 10.1371/journal.pone.0078888. eCollection 
      2014.