PMID- 24454754
OWN - NLM
STAT- MEDLINE
DCOM- 20140917
LR  - 20240320
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 1
DP  - 2014
TI  - The effect of brain-derived neurotrophic factor on periodontal furcation defects.
PG  - e84845
LID - 10.1371/journal.pone.0084845 [doi]
LID - e84845
AB  - This study aimed to observe the regenerative effect of brain-derived neurotrophic 
      factor (BDNF) in a non-human primate furcation defect model. Class II furcation 
      defects were created in the first and second molars of 8 non-human primates to 
      simulate a clinical situation. The defect was filled with either, Group A: BDNF 
      (500 microg/ml) in high-molecular weight-hyaluronic acid (HMW-HA), Group B: BDNF (50 
      microg/ml) in HMW-HA, Group C: HMW-HA acid only, Group D: empty defect, or Group E: 
      BDNF (500 microg/ml) in saline. The healing status for all groups was observed at 
      different time-points with micro computed tomography. The animals were euthanized 
      after 11 weeks, and the tooth-bone specimens were subjected to histologic 
      processing. The results showed that all groups seemed to successfully regenerate 
      the alveolar buccal bone, however, only Group A regenerated the entire 
      periodontal tissue, i.e., alveolar bone, cementum and periodontal ligament. It is 
      suggested that the use of BDNF in combination with a scaffold such as the 
      hyaluronic acid in periodontal furcation defects may be an effective treatment 
      option.
FAU - Jimbo, Ryo
AU  - Jimbo R
AD  - Department of Prosthodontics, Faculty of Odontology, Malmo University, Malmo, 
      Sweden.
FAU - Tovar, Nick
AU  - Tovar N
AD  - Department of Biomaterials and Biomimetics, New York University College of 
      Dentistry, New York, New York, United States of America.
FAU - Janal, Malvin N
AU  - Janal MN
AD  - Department of Epidemiology and Health Promotion, New York University, New York, 
      United States of America.
FAU - Mousa, Ramy
AU  - Mousa R
AD  - Department of Biomaterials and Biomimetics, New York University College of 
      Dentistry, New York, New York, United States of America.
FAU - Marin, Charles
AU  - Marin C
AD  - Department of Dentistry, UNIGRANRIO, Duque de Caxias, Rio de Janeiro, Brazil ; 
      Department of Prosthodontics, Integrated Center for Research, Bauru School of 
      Dentistry, University of Sao Paulo, Bauru, Sao Paulo, Brazil.
FAU - Yoo, Daniel
AU  - Yoo D
AD  - Department of Biomaterials and Biomimetics, New York University College of 
      Dentistry, New York, New York, United States of America.
FAU - Teixeira, Hellen S
AU  - Teixeira HS
AD  - Department of Biomaterials and Biomimetics, New York University College of 
      Dentistry, New York, New York, United States of America.
FAU - Anchieta, Rodolfo B
AU  - Anchieta RB
AD  - Department of Biomaterials and Biomimetics, New York University College of 
      Dentistry, New York, New York, United States of America.
FAU - Bonfante, Estevam A
AU  - Bonfante EA
AD  - Department of Prosthodontics, Integrated Center for Research, Bauru School of 
      Dentistry, University of Sao Paulo, Bauru, Sao Paulo, Brazil.
FAU - Konishi, Akihiro
AU  - Konishi A
AD  - Department of Dentistry, UNIGRANRIO, Duque de Caxias, Rio de Janeiro, Brazil ; 
      Department of Prosthodontics, Integrated Center for Research, Bauru School of 
      Dentistry, University of Sao Paulo, Bauru, Sao Paulo, Brazil.
FAU - Takeda, Katsuhiro
AU  - Takeda K
AD  - Department of Periodontal Medicine, Division of Applied Life Sciences, Hiroshima 
      University Institute of Biomedical & Health Sciences, Minami-ku, Hiroshima, 
      Japan.
FAU - Kurihara, Hidemi
AU  - Kurihara H
AD  - Department of Periodontal Medicine, Division of Applied Life Sciences, Hiroshima 
      University Institute of Biomedical & Health Sciences, Minami-ku, Hiroshima, 
      Japan.
FAU - Coelho, Paulo G
AU  - Coelho PG
AD  - Department of Biomaterials and Biomimetics, New York University College of 
      Dentistry, New York, New York, United States of America.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140114
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9004-61-9 (Hyaluronic Acid)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*pharmacology/therapeutic use
MH  - Dose-Response Relationship, Drug
MH  - Furcation Defects/*drug therapy/pathology/physiopathology
MH  - Hyaluronic Acid/chemistry/pharmacology
MH  - Macaca fascicularis
MH  - Molecular Weight
MH  - Periodontium/drug effects/pathology/physiopathology
MH  - Regeneration/drug effects
PMC - PMC3891769
COIS- Competing Interests: This study was funded by Dentply IH, however, this does not 
      alter the authors' adherence to all the PLOS ONE policies on sharing data and 
      materials.
EDAT- 2014/01/24 06:00
MHDA- 2014/09/18 06:00
PMCR- 2014/01/14
CRDT- 2014/01/24 06:00
PHST- 2013/07/18 00:00 [received]
PHST- 2013/11/19 00:00 [accepted]
PHST- 2014/01/24 06:00 [entrez]
PHST- 2014/01/24 06:00 [pubmed]
PHST- 2014/09/18 06:00 [medline]
PHST- 2014/01/14 00:00 [pmc-release]
AID - PONE-D-13-29949 [pii]
AID - 10.1371/journal.pone.0084845 [doi]
PST - epublish
SO  - PLoS One. 2014 Jan 14;9(1):e84845. doi: 10.1371/journal.pone.0084845. eCollection 
      2014.