PMID- 24455252
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140123
LR  - 20211021
IS  - 2090-2085 (Print)
IS  - 2090-2093 (Electronic)
IS  - 2090-2093 (Linking)
VI  - 2013
DP  - 2013
TI  - Cryoglobulins as potential triggers of inflammation in schizophrenia.
PG  - 125264
LID - 10.1155/2013/125264 [doi]
LID - 125264
AB  - This case study aimed to investigate effects of type III cryoglobulins isolated 
      from the blood of patients with schizophrenia on the production of 
      proinflammatory cytokines interleukin(IL)-1 beta , IL-6 and tumor necrosis factor- alpha 
      (TNF- alpha ), anti-inflammatory cytokine IL-10, and chemotactic cytokines IL-8 and 
      monocyte chemoattractant protein-1 (MCP-1) by peripheral blood mononuclear cells 
      (PBMCs). The experiments were performed in vitro using PBMCs healthy subjects and 
      the blood of patients whit schizoprenia. The enzyme-linked immunosorbent assay 
      and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay were used 
      upon study. The results obtained indicated significant increase (P < 0.05) in 
      IL-1 beta , IL-6, TNF- alpha , IL-8, and MCP-1 production by cultured PBMCs when 
      incubating for 24 hours with cryoglobulins, beginning from 0.4 mg/mL. The gender 
      difference does not affect the cryoglobulins-induced production of these 
      cytokines by PBMCs. No influence of cryoglobulins on production of IL-10 by PBMCs 
      was observed. Also, it was shown that cryoglobulins in concentration </=4 mg/mL 
      possessed no cytotoxic effect towards cultured PBMCs. Based upon the results 
      obtained, we concluded that type III cryoglobulins are implicated in 
      schizophrenia-associated alterations in the immune response through induction of 
      the expression of proinflammatory and chemotactic cytokines by PBMCs.
FAU - Chavushyan, Andranik
AU  - Chavushyan A
AD  - Institute of Molecular Biology, National Academy of Sciences of the Republic of 
      Armenia (NAS RA), 7 Hasratyan Street, 0014 Yerevan, Armenia.
FAU - Hovsepyan, Meri
AU  - Hovsepyan M
AD  - Institute of Molecular Biology, National Academy of Sciences of the Republic of 
      Armenia (NAS RA), 7 Hasratyan Street, 0014 Yerevan, Armenia.
FAU - Boyajyan, Anna
AU  - Boyajyan A
AD  - Institute of Molecular Biology, National Academy of Sciences of the Republic of 
      Armenia (NAS RA), 7 Hasratyan Street, 0014 Yerevan, Armenia.
LA  - eng
PT  - Journal Article
DEP - 20131215
PL  - Egypt
TA  - Schizophr Res Treatment
JT  - Schizophrenia research and treatment
JID - 101576450
PMC - PMC3876917
EDAT- 2014/01/24 06:00
MHDA- 2014/01/24 06:01
PMCR- 2013/12/15
CRDT- 2014/01/24 06:00
PHST- 2013/07/25 00:00 [received]
PHST- 2013/10/03 00:00 [revised]
PHST- 2013/10/11 00:00 [accepted]
PHST- 2014/01/24 06:00 [entrez]
PHST- 2014/01/24 06:00 [pubmed]
PHST- 2014/01/24 06:01 [medline]
PHST- 2013/12/15 00:00 [pmc-release]
AID - 10.1155/2013/125264 [doi]
PST - ppublish
SO  - Schizophr Res Treatment. 2013;2013:125264. doi: 10.1155/2013/125264. Epub 2013 
      Dec 15.