PMID- 24455721
OWN - NLM
STAT- MEDLINE
DCOM- 20140729
LR  - 20211021
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2013
DP  - 2013
TI  - Moving toward personalized medicine in the methadone maintenance treatment 
      program: a pilot study on the evaluation of treatment responses in Taiwan.
PG  - 741403
LID - 10.1155/2013/741403 [doi]
LID - 741403
AB  - This pilot study simultaneously evaluated the effects of various factors, 
      including genetic variations of CYP2B6, CYP2C19, and ABCB1, demographic 
      characteristics, disease states, methadone-drug interactions (MDIs), and 
      poly-substance use, on the treatment responses among non-HIV patients in the 
      methadone maintenance treatment program (MMTP) in Taiwan. A total of 178 patients 
      were recruited from two major hospitals that provided MMTP services in southern 
      Taiwan, and information regarding concomitant medications and diseases was 
      acquired from the National Health Insurance (NHI) program. The results 
      demonstrated that the methadone maintenance dose, CYP2B6 785G allele, and ABCB1 
      2677T allele have positive effects on the methadone plasma concentration. In 
      contrast, patients with HCV coinfection, alcohol problems, and psychiatric 
      diseases may have a negative response to treatment. Thus, a comprehensive 
      evaluation of treatment responses in the MMTP should include not only genetic 
      polymorphisms in methadone metabolism and transporter proteins, but also 
      concomitant diseases, MDIs, and poly-substance use. The results also suggest that 
      personalized medicine may be indispensable for a better outcome of the MMTP.
FAU - Lee, Hsin-Ya
AU  - Lee HY
AD  - School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, No. 100 
      Shih-Chuan 1st Road, Kaohsiung City 807, Taiwan.
FAU - Li, Jih-Heng
AU  - Li JH
AD  - School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, No. 100 
      Shih-Chuan 1st Road, Kaohsiung City 807, Taiwan ; Program in Toxicology, College 
      of Pharmacy, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung 
      City 807, Taiwan.
FAU - Sheu, Yuh-Ling
AU  - Sheu YL
AD  - School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, No. 100 
      Shih-Chuan 1st Road, Kaohsiung City 807, Taiwan.
FAU - Tang, Hsin-Pei
AU  - Tang HP
AD  - Department of Addiction and Forensic Psychiatry, Jianan Mental Hospital, No. 80, 
      Lane 870, Jhong-Shan Road, Rende District, Tainan City 71742, Taiwan.
FAU - Chang, Wei-Chiao
AU  - Chang WC
AD  - School of Pharmacy, Taipei Medical University, No. 250 Wu-Shin Street, Taipei 
      110, Taiwan.
FAU - Tang, Tze-Chun
AU  - Tang TC
AD  - Department of Psychiatry, Kaohsiung Medical University Hospital, No. 100 
      Shih-Chuan 1st Road, Kaohsiung City 807, Taiwan.
FAU - Yeh, Yi-Chun
AU  - Yeh YC
AD  - Department of Psychiatry, Kaohsiung Medical University Hospital, No. 100 
      Shih-Chuan 1st Road, Kaohsiung City 807, Taiwan ; Department of Psychiatry, 
      Faculty of Medicine, College of Medicine, Kaohsiung Medical University, No. 100 
      Shih-Chuan 1st Road, Kaohsiung City 807, Taiwan.
FAU - Wang, Shing-Yaw
AU  - Wang SY
AD  - Department of Psychiatry, Kaohsiung Medical University Hospital, No. 100 
      Shih-Chuan 1st Road, Kaohsiung City 807, Taiwan.
FAU - Liu, Ray-H
AU  - Liu RH
AD  - Department of Medical Technology, Fooyin University, No. 151 Ching-Hsueh Road, 
      Kaohsiung City 831, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131216
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (ABCB1 protein, human)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 1)
RN  - EC 1.14.14.1 (Aryl Hydrocarbon Hydroxylases)
RN  - EC 1.14.14.1 (CYP2B6 protein, human)
RN  - EC 1.14.14.1 (CYP2C19 protein, human)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP2B6)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP2C19)
RN  - UC6VBE7V1Z (Methadone)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 1/*genetics
MH  - Adult
MH  - Alleles
MH  - Aryl Hydrocarbon Hydroxylases/*genetics
MH  - Cytochrome P-450 CYP2B6
MH  - Cytochrome P-450 CYP2C19
MH  - Female
MH  - HIV Infections/drug therapy
MH  - Heroin Dependence/*drug therapy/genetics
MH  - Humans
MH  - Male
MH  - Methadone/blood/*therapeutic use
MH  - Middle Aged
MH  - Opiate Substitution Treatment/methods
MH  - Pilot Projects
MH  - Precision Medicine
MH  - Taiwan
MH  - Treatment Outcome
PMC - PMC3876825
EDAT- 2014/01/24 06:00
MHDA- 2014/07/30 06:00
PMCR- 2013/12/16
CRDT- 2014/01/24 06:00
PHST- 2013/10/18 00:00 [received]
PHST- 2013/11/25 00:00 [accepted]
PHST- 2014/01/24 06:00 [entrez]
PHST- 2014/01/24 06:00 [pubmed]
PHST- 2014/07/30 06:00 [medline]
PHST- 2013/12/16 00:00 [pmc-release]
AID - 10.1155/2013/741403 [doi]
PST - ppublish
SO  - Biomed Res Int. 2013;2013:741403. doi: 10.1155/2013/741403. Epub 2013 Dec 16.