PMID- 24456748
OWN - NLM
STAT- MEDLINE
DCOM- 20150113
LR  - 20140512
IS  - 1532-3129 (Electronic)
IS  - 0021-9975 (Linking)
VI  - 150
IP  - 4
DP  - 2014 May
TI  - Mapping of neurotrophins and their receptors in the adult mouse brain and their 
      role in the pathogenesis of a transgenic murine model of bovine spongiform 
      encephalopathy.
PG  - 449-62
LID - S0021-9975(13)00376-9 [pii]
LID - 10.1016/j.jcpa.2013.11.209 [doi]
AB  - Neurotrophins are a family of growth factors that act on neuronal cells. The 
      neurotrophins include nerve growth factor (NGF), brain-derived neurotrophic 
      factor (BDNF) and neurotrophin (NT)-3, -4 and -5. The action of neurotrophins 
      depends on two transmembrane-receptor signalling systems: (1) the 
      tropomyosin-related kinase (Trk) family of tyrosine kinase receptors (Trk A, Trk 
      B and Trk C) and (2) the p75 neurotrophin receptor (p75(NTR)). The interaction 
      between neurotrophic factors and their receptors may be involved in the 
      mechanisms that regulate the differential susceptibility of neuronal populations 
      in neurodegenerative diseases. The aim of the present study was to evaluate the 
      role of neurotrophins in the pathogenesis of bovine spongiform encephalopathy 
      (BSE) using a transgenic mouse overexpressing bovine prnp (BoTg 110). 
      Histochemistry for Lycopersicum esculentum agglutinin, haematoxylin and eosin 
      staining and immunohistochemistry for the abnormal isoform of the prion protein 
      (PrP(d)), glial fibrillary acidic protein (GFAP), NGF, BDNF, NT-3 and the 
      receptors Trk A, Trk B, Trk C and p75(NTR) was performed. The lesions and the 
      immunolabelling patterns were assessed semiquantitatively in different areas of 
      the brain. No significant differences in the immunolabelling of neurotrophins and 
      their receptors were observed between BSE-inoculated and control animals, except 
      for p75(NTR), which showed increased expression correlating with the distribution 
      of lesions, PrP(d) deposition and gliosis in the BSE-inoculated mice.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Marco-Salazar, P
AU  - Marco-Salazar P
AD  - Department of Animal Medicine and Surgery, Veterinary Faculty, Universitat 
      Autonoma de Barcelona (UAB), 08193 Bellaterra (Cerdanyola del Valles), Barcelona, 
      Spain.
FAU - Marquez, M
AU  - Marquez M
AD  - Department of Animal Medicine and Surgery, Veterinary Faculty, Universitat 
      Autonoma de Barcelona (UAB), 08193 Bellaterra (Cerdanyola del Valles), Barcelona, 
      Spain.
FAU - Fondevila, D
AU  - Fondevila D
AD  - Department of Animal Medicine and Surgery, Veterinary Faculty, Universitat 
      Autonoma de Barcelona (UAB), 08193 Bellaterra (Cerdanyola del Valles), Barcelona, 
      Spain.
FAU - Rabanal, R M
AU  - Rabanal RM
AD  - Department of Animal Medicine and Surgery, Veterinary Faculty, Universitat 
      Autonoma de Barcelona (UAB), 08193 Bellaterra (Cerdanyola del Valles), Barcelona, 
      Spain.
FAU - Torres, J M
AU  - Torres JM
AD  - CISA-INIA, 28130 Valdeolmos, Madrid, Spain.
FAU - Pumarola, M
AU  - Pumarola M
AD  - Department of Animal Medicine and Surgery, Veterinary Faculty, Universitat 
      Autonoma de Barcelona (UAB), 08193 Bellaterra (Cerdanyola del Valles), Barcelona, 
      Spain.
FAU - Vidal, E
AU  - Vidal E
AD  - Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat 
      Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain. Electronic address: 
      enric.vidal@cresa.uab.cat.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131206
PL  - England
TA  - J Comp Pathol
JT  - Journal of comparative pathology
JID - 0102444
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Receptors, Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism/pathology
MH  - Cattle
MH  - Encephalopathy, Bovine Spongiform/*metabolism/pathology
MH  - Mice
MH  - Mice, Transgenic
MH  - Nerve Growth Factors/*metabolism
MH  - Receptors, Nerve Growth Factor/*metabolism
OTO - NOTNLM
OT  - BSE prion
OT  - brain
OT  - immunohistochemistry
OT  - neurotrophins
EDAT- 2014/01/25 06:00
MHDA- 2015/01/15 06:00
CRDT- 2014/01/25 06:00
PHST- 2013/06/12 00:00 [received]
PHST- 2013/09/30 00:00 [revised]
PHST- 2013/11/26 00:00 [accepted]
PHST- 2014/01/25 06:00 [entrez]
PHST- 2014/01/25 06:00 [pubmed]
PHST- 2015/01/15 06:00 [medline]
AID - S0021-9975(13)00376-9 [pii]
AID - 10.1016/j.jcpa.2013.11.209 [doi]
PST - ppublish
SO  - J Comp Pathol. 2014 May;150(4):449-62. doi: 10.1016/j.jcpa.2013.11.209. Epub 2013 
      Dec 6.