PMID- 24456755
OWN - NLM
STAT- MEDLINE
DCOM- 20141016
LR  - 20220331
IS  - 1757-6512 (Electronic)
IS  - 1757-6512 (Linking)
VI  - 4
IP  - 6
DP  - 2013 Nov 25
TI  - Human umbilical cord mesenchymal stromal cells in regenerative medicine.
PG  - 142
LID - 10.1186/scrt353 [doi]
AB  - Cells of the human umbilical cord offer tremendous potential for improving human 
      health. Cells from the Wharton's jelly (umbilical cord stroma) in particular, 
      referred to as human umbilical cord mesenchymal stromal cells (HUCMSCs), hold 
      several advantages that make them appealing for translational research. In the 
      previous issue of Stem Cell Research & Therapy, Chon and colleagues made an 
      important contribution to the HUCMSC literature not only by presenting HUCMSCs as 
      an emerging cell source for intervertebral disc regeneration in general and the 
      nucleus pulposus in particular, but also by demonstrating that an extracellular 
      matrix-based strategy might be preferred over the use of growth factors. By 
      culturing HUCMSCs under hypoxia in serum-free conditions in the presence of 
      Matrigel with laminin-111, they were able to achieve intense collagen II staining 
      by 21 days without the addition of exogenous growth factors. There is tremendous 
      translational significance here in that such raw materials may alleviate the need 
      for the use of growth factors in some instances, and this may have important 
      ramifications in reducing product cost and streamlining regulatory approval. Chon 
      and colleagues provide a promising example of the potential of HUCMSCs, 
      demonstrating the ability to guide HUCMSC differentiation even in the absence of 
      serum and growth factors and supporting the use of HUCMSCs as a viable 
      alternative in intervertebral disc regeneration.
FAU - Detamore, Michael S
AU  - Detamore MS
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20131125
PL  - England
TA  - Stem Cell Res Ther
JT  - Stem cell research & therapy
JID - 101527581
SB  - IM
CON - Stem Cell Res Ther. 2013;4(5):120. PMID: 24405888
MH  - Humans
MH  - Mesenchymal Stem Cells/*cytology
MH  - Umbilical Cord/*cytology
PMC - PMC4029508
EDAT- 2014/01/25 06:00
MHDA- 2014/10/17 06:00
PMCR- 2014/11/25
CRDT- 2014/01/25 06:00
PHST- 2014/01/25 06:00 [entrez]
PHST- 2014/01/25 06:00 [pubmed]
PHST- 2014/10/17 06:00 [medline]
PHST- 2014/11/25 00:00 [pmc-release]
AID - scrt353 [pii]
AID - 10.1186/scrt353 [doi]
PST - epublish
SO  - Stem Cell Res Ther. 2013 Nov 25;4(6):142. doi: 10.1186/scrt353.