PMID- 24456892
OWN - NLM
STAT- MEDLINE
DCOM- 20141201
LR  - 20211203
IS  - 1938-0690 (Electronic)
IS  - 1525-7304 (Linking)
VI  - 15
IP  - 3
DP  - 2014 May
TI  - Clinicopathological features in young patients treated for small-cell lung 
      cancer: significance of immunohistological and molecular analyses.
PG  - 244-7
LID - S1525-7304(13)00257-X [pii]
LID - 10.1016/j.cllc.2013.06.012 [doi]
AB  - BACKGROUND: Small-cell lung cancer in young patients is very rare and has not 
      been adequately described. In addition, malignancies associated with genetic 
      rearrangements of nuclear protein of the testis (NUT) have been reported in young 
      patients. PATIENTS AND METHODS: We reviewed the clinical records of patients 
      younger than 40 years of age who had been diagnosed as having SCLC and had been 
      treated for this condition. We also examined NUT rearrangements using 
      immunohistochemistry (IHC) staining and fluorescence in situ hybridization (FISH) 
      analysis. RESULTS: We evaluated the diagnoses and treatment outcomes of 8 young 
      patients among 747 SCLC patients. Based on further analyses using IHC staining 
      and FISH, NUT rearrangements were found in 2 of these cases. The range of the 
      overall survival period was 3.6 to 49.7 months. The 2 patients with NUT 
      rearrangements survived for less than 12 months. CONCLUSION: NUT rearrangements 
      were identified in 2 patients who had been previously diagnosed as having SCLC. 
      Further attention regarding the diagnosis of SCLC in young patients is needed.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Taniyama, Tomoko Katsui
AU  - Taniyama TK
AD  - Division of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.
FAU - Nokihara, Hiroshi
AU  - Nokihara H
AD  - Division of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan. 
      Electronic address: hnokihar@ncc.go.jp.
FAU - Tsuta, Koji
AU  - Tsuta K
AD  - Division of Pathology, National Cancer Center Hospital, Tokyo, Japan.
FAU - Horinouchi, Hidehito
AU  - Horinouchi H
AD  - Division of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.
FAU - Kanda, Shintaro
AU  - Kanda S
AD  - Division of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.
FAU - Fujiwara, Yutaka
AU  - Fujiwara Y
AD  - Division of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.
FAU - Yamamoto, Noboru
AU  - Yamamoto N
AD  - Division of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.
FAU - Koizumi, Fumiaki
AU  - Koizumi F
AD  - Shien-Lab, National Cancer Center Hospital, Tokyo, Japan.
FAU - Yunokawa, Mayu
AU  - Yunokawa M
AD  - Division of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo, 
      Japan.
FAU - Tamura, Tomohide
AU  - Tamura T
AD  - Division of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20131214
PL  - United States
TA  - Clin Lung Cancer
JT  - Clinical lung cancer
JID - 100893225
RN  - 0 (NUTM1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Oncogene Proteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Female
MH  - Gene Rearrangement
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Lung Neoplasms/*diagnosis/genetics/pathology
MH  - Male
MH  - Neoplasm Proteins
MH  - Nuclear Proteins/*genetics
MH  - Oncogene Proteins/*genetics
MH  - Retrospective Studies
MH  - Small Cell Lung Carcinoma/*diagnosis/genetics/pathology
MH  - Survival Rate
MH  - Young Adult
OTO - NOTNLM
OT  - Chemotherapy
OT  - FISH
OT  - IHC
OT  - NUT midline carcinoma
OT  - NUT rearrangements
EDAT- 2014/01/25 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/01/25 06:00
PHST- 2013/03/23 00:00 [received]
PHST- 2013/05/16 00:00 [revised]
PHST- 2013/06/18 00:00 [accepted]
PHST- 2014/01/25 06:00 [entrez]
PHST- 2014/01/25 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S1525-7304(13)00257-X [pii]
AID - 10.1016/j.cllc.2013.06.012 [doi]
PST - ppublish
SO  - Clin Lung Cancer. 2014 May;15(3):244-7. doi: 10.1016/j.cllc.2013.06.012. Epub 
      2013 Dec 14.