PMID- 24457059
OWN - NLM
STAT- MEDLINE
DCOM- 20141230
LR  - 20211021
IS  - 1746-1596 (Electronic)
IS  - 1746-1596 (Linking)
VI  - 9
DP  - 2014 Jan 23
TI  - Adrenal cortical neoplasms: a study of clinicopathological features related to 
      epidermal growth factor receptor gene status.
PG  - 19
LID - 10.1186/1746-1596-9-19 [doi]
AB  - BACKGROUND: Adrenocortical carcinoma (ACC) is a rare but highly malignant 
      neoplasm with limited treatment options. METHODS: In this study, the 
      clinicopathological features of 22 ACCs and 22 adrenocortical adenomas (ACA) were 
      analyzed, and the EGFR protein expression, EGFR gene mutation status and EGFR 
      gene copy number alteration of all tumors were examined using 
      immunohistochemistry, fluorescence in situ hybridization (FISH), and the Scorpion 
      Amplification Refractory Mutation System (ARMS), respectively. RESULTS: EGFR 
      protein expression was detected in 63.6% of the ACC samples, and EGFR FISH was 
      positive in 50% of the ACC samples (all were high polysomy on chromosome 7). In 
      contrast, 27.3% of the ACA samples demonstrated EGFR expression, and none of the 
      ACA samples tested positive by FISH. There were significant differences between 
      the ACC and ACA in terms of protein expression (P = 0.035) and gene copy number 
      alterations (P < 0.001). CONCLUSIONS: EGFR protein expression and high polysomy 
      on chromosome 7 are frequent abnormalities in ACC than in ACA. VIRTUAL SLIDES: 
      The virtual slide(s) for this article can be found here: 
      http://www.diagnosticpathology.diagnomx.eu/vs/2068470757103500.
FAU - Zhang, Jing
AU  - Zhang J
FAU - Wang, Cuiping
AU  - Wang C
FAU - Gao, Jie
AU  - Gao J
FAU - Sun, Jian
AU  - Sun J
FAU - Zeng, Xuan
AU  - Zeng X
FAU - Wu, Shafei
AU  - Wu S
FAU - Liang, Zhiyong
AU  - Liang Z
AD  - Department of Pathology, Peking Union Medical College Hospital, Chinese Academy 
      of Medical Sciences and Peking Union Medical College, 1 Shuai Fu Yuan Hu Tong, 
      Beijing 100730, People's Republic of China. liangzhiyong1220@yahoo.com.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140123
PL  - England
TA  - Diagn Pathol
JT  - Diagnostic pathology
JID - 101251558
RN  - 0 (Biomarkers, Tumor)
RN  - EC 2.7.10.1 (EGFR protein, human)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Adolescent
MH  - Adrenal Cortex Neoplasms/chemistry/*genetics/pathology
MH  - Adrenocortical Adenoma/chemistry/*genetics/pathology
MH  - Adrenocortical Carcinoma/chemistry/*genetics/pathology
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/analysis/*genetics
MH  - Carcinoma/chemistry/*genetics/pathology
MH  - Child
MH  - Child, Preschool
MH  - Chromosomes, Human, Pair 7
MH  - DNA Mutational Analysis
MH  - ErbB Receptors/analysis/*genetics
MH  - Female
MH  - Gene Dosage
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Mutation
MH  - Phenotype
MH  - Young Adult
PMC - PMC3976095
EDAT- 2014/01/25 06:00
MHDA- 2014/12/31 06:00
PMCR- 2014/01/23
CRDT- 2014/01/25 06:00
PHST- 2013/07/19 00:00 [received]
PHST- 2013/12/18 00:00 [accepted]
PHST- 2014/01/25 06:00 [entrez]
PHST- 2014/01/25 06:00 [pubmed]
PHST- 2014/12/31 06:00 [medline]
PHST- 2014/01/23 00:00 [pmc-release]
AID - 1746-1596-9-19 [pii]
AID - 10.1186/1746-1596-9-19 [doi]
PST - epublish
SO  - Diagn Pathol. 2014 Jan 23;9:19. doi: 10.1186/1746-1596-9-19.