PMID- 24457083
OWN - NLM
STAT- MEDLINE
DCOM- 20140512
LR  - 20220316
IS  - 1532-8392 (Electronic)
IS  - 0046-8177 (Linking)
VI  - 45
IP  - 4
DP  - 2014 Apr
TI  - Diagnostic utility of MYC amplification and anti-MYC immunohistochemistry in 
      atypical vascular lesions, primary or radiation-induced mammary angiosarcomas, 
      and primary angiosarcomas of other sites.
PG  - 709-16
LID - S0046-8177(13)00475-9 [pii]
LID - 10.1016/j.humpath.2013.11.002 [doi]
AB  - Breast cancer patients who receive radiation therapy or develop chronic 
      lymphedema following axillary dissection can develop secondary mammary 
      angiosarcomas (ASs) and, additionally, atypical vascular lesions (AVLs) in the 
      former group. Recently, MYC amplification by fluorescence in situ hybridization 
      (FISH) has been identified in secondary mammary AS but not in AVL and most 
      primary mammary AS as well as AS of other sites. We studied MYC amplification and 
      MYC protein expression in 7 radiation-induced AVLs, 9 secondary mammary ASs, 17 
      primary mammary ASs, and 20 primary ASs of other sites by FISH analysis and 
      immunohistochemistry. All 9 secondary mammary ASs showed gene amplification and 
      protein expression, whereas neither was found in any of 7 AVLs. No MYC 
      amplification or protein expression was identified in any of the 17 primary 
      mammary ASs. Among primary ASs of other sites, 1 cardiac AS and 1 skin AS showed 
      gene amplification and protein expression. The remaining 18 did not show 
      amplification (90%), but some demonstrated protein expression (39%). We conclude 
      that MYC amplification by FISH is present in secondary mammary AS but not in AVL. 
      We also found MYC amplification in 1 primary skin AS and 1 primary cardiac AS. 
      There was 100% concordance between MYC amplification and protein expression in 
      all AVL, primary mammary AS, and secondary mammary AS, whereas only 65% 
      concordance was found in AS of other sites. MYC protein expression in AS can be 
      helpful in certain diagnostic scenarios in the breast but not in other sites.
CI  - (c) 2014.
FAU - Ginter, Paula S
AU  - Ginter PS
AD  - Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 
      New York, NY 10065, USA. Electronic address: psg9003@nyp.org.
FAU - Mosquera, Juan Miguel
AU  - Mosquera JM
AD  - Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 
      New York, NY 10065, USA; Institute for Precision Medicine of Weill Cornell and 
      New York-Presbyterian Hospital, New York, NY 10065, USA.
FAU - MacDonald, Theresa Y
AU  - MacDonald TY
AD  - Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 
      New York, NY 10065, USA.
FAU - D'Alfonso, Timothy M
AU  - D'Alfonso TM
AD  - Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 
      New York, NY 10065, USA.
FAU - Rubin, Mark A
AU  - Rubin MA
AD  - Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 
      New York, NY 10065, USA; Institute for Precision Medicine of Weill Cornell and 
      New York-Presbyterian Hospital, New York, NY 10065, USA.
FAU - Shin, Sandra J
AU  - Shin SJ
AD  - Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 
      New York, NY 10065, USA.
LA  - eng
PT  - Journal Article
DEP - 20131112
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
RN  - Angiosarcoma of the breast
SB  - IM
MH  - Adult
MH  - Aged
MH  - Breast/pathology/radiation effects
MH  - Breast Neoplasms/*diagnosis/*genetics/metabolism
MH  - Female
MH  - Gene Amplification
MH  - Genes, myc/*genetics
MH  - Hemangiosarcoma/*diagnosis/*genetics/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Middle Aged
MH  - Neoplasms, Radiation-Induced/*diagnosis/*genetics/metabolism
MH  - Radiotherapy/adverse effects
MH  - Tissue Array Analysis
MH  - Young Adult
OTO - NOTNLM
OT  - Atypical vascular lesion
OT  - MYC
OT  - Radiation
OT  - Secondary angiosarcoma
EDAT- 2014/01/25 06:00
MHDA- 2014/05/13 06:00
CRDT- 2014/01/25 06:00
PHST- 2013/07/19 00:00 [received]
PHST- 2013/10/30 00:00 [revised]
PHST- 2013/11/01 00:00 [accepted]
PHST- 2014/01/25 06:00 [entrez]
PHST- 2014/01/25 06:00 [pubmed]
PHST- 2014/05/13 06:00 [medline]
AID - S0046-8177(13)00475-9 [pii]
AID - 10.1016/j.humpath.2013.11.002 [doi]
PST - ppublish
SO  - Hum Pathol. 2014 Apr;45(4):709-16. doi: 10.1016/j.humpath.2013.11.002. Epub 2013 
      Nov 12.