PMID- 24457347
OWN - NLM
STAT- MEDLINE
DCOM- 20140929
LR  - 20140206
IS  - 1531-7056 (Electronic)
IS  - 0267-1379 (Linking)
VI  - 30
IP  - 2
DP  - 2014 Mar
TI  - Advances in coeliac disease.
PG  - 154-62
LID - 10.1097/MOG.0000000000000041 [doi]
AB  - PURPOSE OF REVIEW: To summarize the recent advances in coeliac disease. RECENT 
      FINDINGS: Details of the polygenic nature of coeliac disease with the human 
      leukocyte antigen (HLA) locus as the dominating genetic element have been 
      uncovered. The existence of a large number of non-HLA coeliac disease genes, only 
      partly shared by each individual patient, suggests the genetic heterogeneity of 
      the disease. The critical role for HLA-DQ-restricted CD4 T cells recognizing 
      antigenic gluten peptides is further substantiated. Involvement of CD8 T cells 
      has received new attention. Other components of wheat than gluten, in particular 
      the amylase trypsin inhibitors, may also play a role. The disease is becoming 
      more prevalent. New guidelines state that coeliac disease diagnosis in children 
      can be made on the basis of clinical signs, serology and genetics without the 
      need of biopsy. The clinical entity 'noncoeliac gluten sensitivity' has received 
      much attention, but diagnostic and pathophysiological definitions are still 
      elusive. The risk for mortality and morbidity in coeliac disease is less than 
      previously thought. SUMMARY: Our understanding of the basic and clinical aspects 
      of coeliac disease increases. Coeliac disease stands out as a major health 
      problem of almost global occurrence. Case finding, distinguishing coeliac disease 
      from other gluten-sensitive conditions, better care and balanced use of resources 
      are the current challenges.
FAU - Lundin, Knut E A
AU  - Lundin KE
AD  - aCentre for Immune Regulation and Department of Immunology, University of Oslo 
      and Oslo University Hospital - Rikshospitalet bDepartment of Gastroenterology, 
      Oslo University Hospital - Rikshospitalet, Oslo, Norway.
FAU - Sollid, Ludvig M
AU  - Sollid LM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Opin Gastroenterol
JT  - Current opinion in gastroenterology
JID - 8506887
RN  - 8002-80-0 (Glutens)
SB  - IM
MH  - Celiac Disease/*diagnosis/genetics/immunology/therapy
MH  - Diet, Gluten-Free
MH  - Genetic Predisposition to Disease
MH  - Glutens/immunology
MH  - Humans
EDAT- 2014/01/25 06:00
MHDA- 2014/09/30 06:00
CRDT- 2014/01/25 06:00
PHST- 2014/01/25 06:00 [entrez]
PHST- 2014/01/25 06:00 [pubmed]
PHST- 2014/09/30 06:00 [medline]
AID - 10.1097/MOG.0000000000000041 [doi]
PST - ppublish
SO  - Curr Opin Gastroenterol. 2014 Mar;30(2):154-62. doi: 
      10.1097/MOG.0000000000000041.