PMID- 24457548
OWN - NLM
STAT- MEDLINE
DCOM- 20141118
LR  - 20140401
IS  - 1421-9913 (Electronic)
IS  - 0014-3022 (Linking)
VI  - 71
IP  - 3-4
DP  - 2014
TI  - Validity of minimal clinically important difference values for the multiple 
      sclerosis walking scale-12?
PG  - 196-202
LID - 10.1159/000356116 [doi]
AB  - BACKGROUND AND OBJECTIVE: Minimal clinically important difference (MCID) values 
      of 4 and 6 points have been proposed for interpreting meaningful change in 
      Multiple Sclerosis Walking Scale-12 (MSWS-12) scores. This study examined the 
      validity of those MCID values based on capturing corresponding changes in other 
      walking outcomes in persons with multiple sclerosis (MS). METHODS: On 2 occasions 
      separated by 6 months, 82 persons with MS completed the MSWS-12, timed 25-ft walk 
      (T25FW), 6-min walk (6MW), and gait analysis, and then wore an accelerometer over 
      a 7-day period. We generated change scores for the MSWS-12 and formed groups of 
      stable, worsened, and improved perceived walking based on both 4- and 6-point 
      changes. The groups were compared for corresponding changes in other walking 
      measures over time using mixed-model ANOVAs. RESULTS: The mixed-model ANOVAs did 
      not identify statistically significant group-by-time interactions on the T25FW (p 
      = 0.98 and p = 0.67), the 6MW (p = 0.89 and p = 0.72), gait (p = 0.54 and p = 
      0.21), or accelerometry (p = 0.40 and p = 0.68) for MCID values of 4- or 6-point 
      changes in MSWS-12 scores. CONCLUSIONS: We did not confirm that MCID values of 4 
      and 6 points for the MSWS-12 correspond with changes in performance, gait, and 
      free-living assessments of walking in MS.
CI  - (c) 2014 S. Karger AG, Basel.
FAU - Motl, Robert W
AU  - Motl RW
AD  - Department of Kinesiology and Community Health, University of Illinois at 
      Urbana-Champaign, Urbana, Ill., USA.
FAU - Learmonth, Yvonne C
AU  - Learmonth YC
FAU - Pilutti, Lara A
AU  - Pilutti LA
FAU - Dlugonski, Deirdre
AU  - Dlugonski D
FAU - Klaren, Rachel
AU  - Klaren R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140121
PL  - Switzerland
TA  - Eur Neurol
JT  - European neurology
JID - 0150760
SB  - IM
MH  - *Disability Evaluation
MH  - Female
MH  - Gait Disorders, Neurologic/*diagnosis/etiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*complications
MH  - Neurologic Examination/*methods
MH  - *Walking
EDAT- 2014/01/25 06:00
MHDA- 2014/11/19 06:00
CRDT- 2014/01/25 06:00
PHST- 2013/08/02 00:00 [received]
PHST- 2013/09/29 00:00 [accepted]
PHST- 2014/01/25 06:00 [entrez]
PHST- 2014/01/25 06:00 [pubmed]
PHST- 2014/11/19 06:00 [medline]
AID - 000356116 [pii]
AID - 10.1159/000356116 [doi]
PST - ppublish
SO  - Eur Neurol. 2014;71(3-4):196-202. doi: 10.1159/000356116. Epub 2014 Jan 21.