PMID- 24457834
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1804-7521 (Electronic)
IS  - 1213-8118 (Linking)
VI  - 159
IP  - 2
DP  - 2015 Jun
TI  - Unstable angina pectoris prior to ST elevation myocardial infarction in patients 
      treated with primary percutaneous coronary intervention has no influence on 
      prognosis.
PG  - 251-8
LID - 10.5507/bp.2014.003 [doi]
AB  - BACKGROUND: Pre-infarction unstable angina pectoris (UAP) can be considered 
      ischemic preconditioning. The aim of this study was to compare short and long 
      term outcomes in patients with or without pre-infarction UAP and ST elevation 
      myocardial infarction (STEMI) treated with primary percutaneous coronary 
      intervention (PCI). METHODS: 593 patients with STEMI (388 without and 205 with 
      UAP) were evaluated. Levels of biomarkers (troponin I, BNP, NT-ProBNP, neopterin, 
      endoglin and pentraxin-3) at hospital admission and 24 h after STEMI onset were 
      assessed. Echocardiography was undertaken on the fourth day after MI and after 12 
      months. The median follow-up was 37 months. RESULTS: We found no significant 
      differences in sex, age or risk factors for atherosclerosis between the UAP and 
      non-UAP group. As the median time from the onset of chest pain to admission was 
      significantly longer in the UAP group (228 min vs 258 min; P=0.009), we used a 
      propensity score to obtain comparable matched groups for use in further analyses. 
      The levels of NT-proBNP were significantly higher on admission and after 24 hours 
      in the UAP group. Left ventricular functions according to invasive and 
      echocardiographic parameters were entirely comparable at hospitalization and 
      after 12 months. No differences were found in severity index of acute heart 
      failure during hospitalization. The incidence of major acute coronary events 
      during follow-up was comparable for the groups. CONCLUSIONS: In patients with 
      STEMI treated with primary PCI, pre-infarction UAP has no beneficial clinical 
      effect during hospitalization or during long-term follow-up.
FAU - Kluz, Krystyna
AU  - Kluz K
AD  - Department of Internal Cardiology, Medical Faculty, Masaryk University, Brno, 
      Czech Republic.
AD  - Hospital Podlesi a.s., Trinec.
FAU - Parenica, Jiri
AU  - Parenica J
AD  - Department of Cardiology, Faculty Hospital Brno.
AD  - Department of Cardiovascular Disease, International Clinical Research Center, St. 
      Anne s University Hospital in Brno.
FAU - Kubkova, Lenka
AU  - Kubkova L
AD  - Department of Internal Cardiology, Medical Faculty, Masaryk University, Brno, 
      Czech Republic.
AD  - Department of Cardiology, Faculty Hospital Brno.
AD  - Department of Cardiovascular Disease, International Clinical Research Center, St. 
      Anne s University Hospital in Brno.
FAU - Littnerova, Simona
AU  - Littnerova S
AD  - Institute of Biostatistics and Analyses, Masaryk University, Brno.
FAU - Tomandl, Josef
AU  - Tomandl J
AD  - Department of Internal Cardiology, Medical Faculty, Masaryk University, Brno, 
      Czech Republic.
FAU - Poloczek, Martin
AU  - Poloczek M
AD  - Department of Cardiology, Faculty Hospital Brno.
FAU - Toman, Ondrej
AU  - Toman O
AD  - Department of Cardiology, Faculty Hospital Brno.
FAU - Tesak, Martin
AU  - Tesak M
AD  - Department of Cardiology, Faculty Hospital Brno.
AD  - Hospital Trebic, Trebic-Jejkov.
FAU - Cermakova, Zdenka
AU  - Cermakova Z
AD  - Department of Biochemistry, Faculty Hospital Brno.
FAU - Gottwaldova, Jana
AU  - Gottwaldova J
AD  - Department of Biochemistry, Faculty Hospital Brno.
FAU - Manousek, Jan
AU  - Manousek J
AD  - Department of Cardiology, Faculty Hospital Brno.
FAU - Pavkova Goldbergova, Monika
AU  - Pavkova Goldbergova M
AD  - Department of Internal Cardiology, Medical Faculty, Masaryk University, Brno, 
      Czech Republic.
FAU - Spinar, Jindrich
AU  - Spinar J
AD  - Department of Internal Cardiology, Medical Faculty, Masaryk University, Brno, 
      Czech Republic.
AD  - Department of Cardiology, Faculty Hospital Brno.
AD  - Department of Cardiovascular Disease, International Clinical Research Center, St. 
      Anne s University Hospital in Brno.
FAU - Jarkovsky, Jiri
AU  - Jarkovsky J
AD  - Institute of Biostatistics and Analyses, Masaryk University, Brno.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140123
PL  - Czech Republic
TA  - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
JT  - Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, 
      Czechoslovakia
JID - 101140142
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Angina, Unstable/*complications/mortality
MH  - Biomarkers/metabolism
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/etiology
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/mortality/*surgery
MH  - Natriuretic Peptide, Brain/metabolism
MH  - Peptide Fragments/metabolism
MH  - *Percutaneous Coronary Intervention
MH  - Prognosis
MH  - Prospective Studies
MH  - Recurrence
MH  - Stroke/etiology
MH  - Time-to-Treatment
OTO - NOTNLM
OT  - STEMI
OT  - natriuretic peptides
OT  - pre-infarction angina pectoris
OT  - primary PCI
EDAT- 2014/01/25 06:00
MHDA- 2016/12/15 06:00
CRDT- 2014/01/25 06:00
PHST- 2013/08/08 00:00 [received]
PHST- 2014/01/14 00:00 [accepted]
PHST- 2014/01/25 06:00 [entrez]
PHST- 2014/01/25 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.5507/bp.2014.003 [doi]
PST - ppublish
SO  - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015 Jun;159(2):251-8. doi: 
      10.5507/bp.2014.003. Epub 2014 Jan 23.