PMID- 24457985
OWN - NLM
STAT- MEDLINE
DCOM- 20141029
LR  - 20140226
IS  - 1932-751X (Electronic)
IS  - 1932-7501 (Linking)
VI  - 34
IP  - 2
DP  - 2014 Mar-Apr
TI  - Exercise capacity and physical activity in patients with COPD and healthy 
      subjects classified as Medical Research Council dyspnea scale grade 2.
PG  - 150-4
LID - 10.1097/HCR.0000000000000038 [doi]
AB  - PURPOSE: Patients with chronic obstructive pulmonary disease (COPD) are often 
      classified by Medical Research Council (MRC) dyspnea grade and comparisons thus 
      made to healthy individuals. The MRC grade of a healthy population is assumed to 
      be grade 1, although this may be inaccurate. Physical activity and exercise 
      capacity are not well-defined for those with MRC grade 2. This study was 
      undertaken to establish whether there are differences in physical activity and 
      exercise capacity between individuals with COPD and healthy controls, who have 
      all assessed themselves as MRC grade 2. METHODS: Patients with COPD (n = 83) and 
      19 healthy controls, with a self-selected MRC grade of 2, completed the 
      Incremental Shuttle Walk Test (ISWT) and wore a SenseWear (BodyMedia, Pittsburgh, 
      PA) activity monitor for 12 hours for 2 weekdays. RESULTS: Adjusting for age, 
      step count and ISWT were significantly reduced for those with COPD, compared with 
      healthy controls (P < .05). Patients with COPD achieved mean (SD) 425.5 (131.3) m 
      on ISWT and took 6022 (3276) steps per day compared with 647.8 (146.3) m and 9462 
      (4141) steps per day for healthy controls. For subjects achieving 10 000 steps 
      per day, 8 (42.11%) healthy controls achieved this level compared with 7 (8.43%) 
      patients with COPD (P < .01). CONCLUSIONS: Healthy individuals may report 
      functional limitations and categorize themselves as MRC grade 2. However, despite 
      both groups subjectively considering themselves similarly functionally limited, 
      exercise capacity and physical activity were significantly reduced in patients 
      with COPD compared with healthy participants. This highlights the importance of 
      early interventions to increase physical performance and prevent functional 
      decline for patients with COPD.
FAU - Johnson-Warrington, Vicki
AU  - Johnson-Warrington V
AD  - NIHR CLAHRC-LNR, Pulmonary Rehabilitation Research Group, Glenfield Hospital, 
      University Hospitals Leicester NHS Trust, Leicester, the United Kingdom (Mss 
      Johnson-Warrington and Harrison and Drs Mitchell, Steiner, Morgan, and Singh); 
      and Faculty of Health and Life Sciences, Coventry University, Coventry, the 
      United Kingdom (Dr Singh).
FAU - Harrison, Samantha
AU  - Harrison S
FAU - Mitchell, Katy
AU  - Mitchell K
FAU - Steiner, Mick
AU  - Steiner M
FAU - Morgan, Mike
AU  - Morgan M
FAU - Singh, Sally
AU  - Singh S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Cardiopulm Rehabil Prev
JT  - Journal of cardiopulmonary rehabilitation and prevention
JID - 101291247
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Dyspnea/*classification/*physiopathology
MH  - Exercise Test
MH  - Exercise Tolerance/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Activity/*physiology
MH  - Pulmonary Disease, Chronic Obstructive/*physiopathology
EDAT- 2014/01/25 06:00
MHDA- 2014/10/30 06:00
CRDT- 2014/01/25 06:00
PHST- 2014/01/25 06:00 [entrez]
PHST- 2014/01/25 06:00 [pubmed]
PHST- 2014/10/30 06:00 [medline]
AID - 10.1097/HCR.0000000000000038 [doi]
PST - ppublish
SO  - J Cardiopulm Rehabil Prev. 2014 Mar-Apr;34(2):150-4. doi: 
      10.1097/HCR.0000000000000038.