PMID- 2445876
OWN - NLM
STAT- MEDLINE
DCOM- 19880106
LR  - 20181113
IS  - 0169-4197 (Print)
IS  - 0169-4197 (Linking)
VI  - 2
IP  - 3
DP  - 1987 Jun
TI  - Caerulein stimulates pancreatic growth and somatic growth in suckling rats.
PG  - 171-81
AB  - This study deals with the stimulatory effect of caerulein on pancreatic and 
      somatic growth in CFY suckling rats before weaning. After birth, caerulein (0.25, 
      0.5, 1, 3, 10 and 30 micrograms/kg) was given subcutaneously (s.c.) 3 times daily 
      for 10 days. Saline-treated newborn rats were used as control. Caerulein 
      increased pancreatic weight and total pancreatic trypsin activity reaching the 
      maximum at 1 microgram/kg dose; higher doses did not cause higher values. On this 
      basis 1 microgram/kg caerulein was applied s.c. 3 times daily for 3, 5, 10 and 20 
      days. At the end of the treatment pancreatic weight, total pancreatic protein, 
      DNA content, trypsin and amylase activity was measured. Increases in body weight 
      due to caerulein treatment were found from 6 days of treatment. Caerulein 
      treatment increased pancreatic weight, total pancreatic DNA and protein content, 
      and trypsin and amylase activity when applied for 5, 10 and 20 days. Treatment 
      for 3, 5, 10 and 20 days with caerulein preferentially increased pancreatic 
      trypsin activity compared to amylase activity. Trypsin activity per mg DNA 
      increased with time in each caerulein-treated group demonstrating that the effect 
      of caerulein increases with duration of treatment. In the saline-treated control 
      group, however, pronounced increase in pancreatic amylase activity compared to 
      that of trypsin activity was found in the age between days 11 and 21. This may be 
      explained by the observation that the plasma corticosterone level increased 
      during this period of postnatal life. The effect of caerulein in promoting 
      pancreatic and somatic growth of suckling rats before weaning may be attributed 
      to a specific enhancing effect of the peptide on proteolytic (e.g. trypsin) 
      enzyme production of the pancreas.
FAU - Papp, M
AU  - Papp M
AD  - Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest.
FAU - Varga, G
AU  - Varga G
FAU - Dobronyi, I
AU  - Dobronyi I
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Pancreatol
JT  - International journal of pancreatology : official journal of the International 
      Association of Pancreatology
JID - 8703511
RN  - 888Y08971B (Ceruletide)
RN  - 9007-49-2 (DNA)
RN  - EC 3.2.1.- (Amylases)
RN  - EC 3.4.21.4 (Trypsin)
SB  - IM
MH  - Amylases/metabolism
MH  - Animals
MH  - Animals, Suckling
MH  - Ceruletide/administration & dosage/*pharmacology
MH  - DNA/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Organ Size/drug effects
MH  - Pancreas/drug effects/*growth & development/metabolism
MH  - Rats
MH  - Trypsin/metabolism
EDAT- 1987/06/01 00:00
MHDA- 1987/06/01 00:01
CRDT- 1987/06/01 00:00
PHST- 1987/06/01 00:00 [pubmed]
PHST- 1987/06/01 00:01 [medline]
PHST- 1987/06/01 00:00 [entrez]
AID - 10.1007/BF02788215 [doi]
PST - ppublish
SO  - Int J Pancreatol. 1987 Jun;2(3):171-81. doi: 10.1007/BF02788215.