PMID- 24459924
OWN - NLM
STAT- MEDLINE
DCOM- 20140407
LR  - 20190221
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 27
IP  - 18
DP  - 2013 Sep
TI  - [Expression and significance of phosphated signal transducer and activator of 
      transcription 3 and p53 protein in laryngeal squamous cell carcinoma].
PG  - 991-4
AB  - OBJECTIVE: To investigate the expression and clinical significance of phosphated 
      signal transducer and activator of transcription 3 (p-STAT3) and p53 protein in 
      laryngeal squamous cell carcinoma (LSCC), and the relationship between the two 
      genes. METHOD: Formalin-fixed and paraffin-embedded tissues, which came from 60 
      cases of LSCC and 32 samples of normal mucosa over 2.0 cm away from tumor margin 
      in 32 patients with total or subtotal laryngectomy were detected for the 
      expression of p-STAT3 and p53 protein by in SP immunohistochemistry. Micro-image 
      analysis system was used to determine the optical density,and the result was 
      analyzed statistically. RESULT: There is over expression of p-STAT3 and p53 
      protein in LSCC. The expression of p-STAT3 and p53 protein in LSCC was associated 
      with clinical stage and lymph nodal metastases (P < 0.05). There was a positive 
      correlation between the expression of p-STAT3 and P53 protein. The correlation 
      coefficient (r) was 0.6558 (P < 0.01). CONCLUSION: The expression of p-STAT3 and 
      p53 protein may play an important role in the tumorigenesis,metastases and poor 
      prognosis of LSCC. There was a positive correlation between the over expression 
      of p-STAT3 and p53 protein in LSCC.
FAU - Dai, Lili
AU  - Dai L
AD  - Department of Otolaryngology-Head and Neck Surgery, the Affiliated Hospital of 
      Hangzhou Normal University, Hangzhou, 310015, China.
FAU - Liu, Tingyan
AU  - Liu T
AD  - Department of Otolaryngology-Head and Neck Surgery, the Affiliated Hospital of 
      Hangzhou Normal University, Hangzhou, 310015, China.
FAU - Zhou, Xuehua
AU  - Zhou X
AD  - Department of Otolaryngology-Head and Neck Surgery, the Affiliated Hospital of 
      Hangzhou Normal University, Hangzhou, 310015, China.
FAU - Wei, Qingyu
AU  - Wei Q
AD  - Department of Otolaryngology-Head and Neck Surgery, the Affiliated Hospital of 
      Hangzhou Normal University, Hangzhou, 310015, China.
FAU - Li, Yuan
AU  - Li Y
AD  - Department of Otolaryngology-Head and Neck Surgery, the Affiliated Hospital of 
      Hangzhou Normal University, Hangzhou, 310015, China.
FAU - Cui, Caiuia
AU  - Cui C
AD  - Department of Otolaryngology-Head and Neck Surgery, the Affiliated Hospital of 
      Hangzhou Normal University, Hangzhou, 310015, China.
FAU - Li, Mao
AU  - Li M
AD  - Department of Otolaryngology-Head and Neck Surgery, the Affiliated Hospital of 
      Hangzhou Normal University, Hangzhou, 310015, China.
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (STAT3 protein, human)
RN  - 0 (TP53 protein, human)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Female
MH  - Head and Neck Neoplasms/*metabolism/pathology
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Phosphorylation
MH  - STAT3 Transcription Factor/*metabolism
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Tumor Suppressor Protein p53/*metabolism
EDAT- 2014/01/28 06:00
MHDA- 2014/04/08 06:00
CRDT- 2014/01/28 06:00
PHST- 2014/01/28 06:00 [entrez]
PHST- 2014/01/28 06:00 [pubmed]
PHST- 2014/04/08 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Sep;27(18):991-4.