PMID- 24460099
OWN - NLM
STAT- MEDLINE
DCOM- 20150720
LR  - 20190116
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 55
IP  - 11
DP  - 2014 Nov
TI  - Safety of high-dose micafungin for patients with hematological diseases.
PG  - 2572-6
LID - 10.3109/10428194.2014.885514 [doi]
AB  - This study was conducted as a retrospective, observational, exploratory cohort 
      study with the aim of elucidating the safety profile of micafungin at doses 
      exceeding 150 mg daily. We identified adult patients with hematological diseases 
      who had received micafungin therapy for >/= 7 consecutive days. Twenty-six patients 
      administered micafungin at 300 mg daily (high-dose group) were compared with 58 
      patients administered micafungin at 150 mg daily (standard-dose group). The most 
      frequent adverse events (AEs) were hepatotoxicity, hypertension and diarrhea. AEs 
      were recorded in 42 (72%) and 19 (73%) patients in the standard-dose and 
      high-dose groups, respectively (p = 1.00). Hepatobiliary AEs were noted in 28 
      (48%) and 15 (58%) patients, respectively (p = 0.48). Serious AEs and resultant 
      treatment discontinuation were infrequent. Our results suggest that micafungin 
      was safe and well tolerated at 300 mg daily.
FAU - Yamazaki, Sho
AU  - Yamazaki S
AD  - Department of Hematology and Oncology, Graduate School of Medicine, The 
      University of Tokyo , Tokyo , Japan.
FAU - Nakamura, Fumihiko
AU  - Nakamura F
FAU - Yoshimi, Akihide
AU  - Yoshimi A
FAU - Ichikawa, Motoshi
AU  - Ichikawa M
FAU - Nannya, Yasuhito
AU  - Nannya Y
FAU - Kurokawa, Mineo
AU  - Kurokawa M
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20140307
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Antifungal Agents)
RN  - 0 (Echinocandins)
RN  - 0 (Lipopeptides)
RN  - R10H71BSWG (Micafungin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antifungal Agents/administration & dosage/adverse effects/*therapeutic use
MH  - Chemical and Drug Induced Liver Injury/etiology
MH  - Diarrhea/chemically induced
MH  - Dose-Response Relationship, Drug
MH  - Echinocandins/administration & dosage/adverse effects/*therapeutic use
MH  - Female
MH  - Hematologic Diseases/*complications
MH  - Humans
MH  - Hypertension/chemically induced
MH  - Lipopeptides/administration & dosage/adverse effects/*therapeutic use
MH  - Male
MH  - Micafungin
MH  - Middle Aged
MH  - Mycoses/complications/*drug therapy
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Micafungin
OT  - adverse events
OT  - hepatotoxicity
OT  - high dose
OT  - safety
EDAT- 2014/01/28 06:00
MHDA- 2015/07/21 06:00
CRDT- 2014/01/28 06:00
PHST- 2014/01/28 06:00 [entrez]
PHST- 2014/01/28 06:00 [pubmed]
PHST- 2015/07/21 06:00 [medline]
AID - 10.3109/10428194.2014.885514 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2014 Nov;55(11):2572-6. doi: 10.3109/10428194.2014.885514. Epub 
      2014 Mar 7.