PMID- 24461541
OWN - NLM
STAT- MEDLINE
DCOM- 20141208
LR  - 20161125
IS  - 1532-2653 (Electronic)
IS  - 0967-5868 (Linking)
VI  - 21
IP  - 5
DP  - 2014 May
TI  - Adult supratentorial extra-pineal primitive neuro-ectodermal tumors.
PG  - 803-9
LID - S0967-5868(13)00509-2 [pii]
LID - 10.1016/j.jocn.2013.07.025 [doi]
AB  - Primitive neuro-ectodermal tumors (PNET) are rare malignant brain tumors, mostly 
      undifferentiated, that tend to spread through the cerebrospinal fluid (CSF). 
      Extra-pineal supratentorial PNET in adults are very rare. Published guidelines 
      for adult PNET were not available until 2011, and at our institute surgeons and 
      oncologists did not have consensus on imaging evaluation or treatment protocols 
      between 1994 to 2008. Twenty-two consecutive adult patients with extra-pineal 
      supratentorial PNET from this period were reviewed in this retrospective study. 
      Their clinical profiles and radiologic images were evaluated. A pathological 
      review based on the 2007 World Health Organization criteria was also conducted. 
      Prognostic factors were analyzed. The 1 and 3 year overall survival rates were 
      64% and 32% for adult extra-pineal supratentorial PNET, respectively. Limited by 
      the small number of tumors in this series, we suggest that negative prognostic 
      factors are multiplicity at onset, initial CSF seeding, and tumor 
      differentiation. Although age of onset, extent of resection, radiation and 
      chemotherapy were assumed to be good prognostic factors, the analysis did not 
      reveal strong significance for overall survival with univariate and multivariate 
      analysis. We believe more detailed investigations on the genetic/molecular basis 
      of supratentorial PNET and their clinical outcomes are warranted.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Zheng, Yun-Cong
AU  - Zheng YC
AD  - Department of Neurosurgery, Chang Gung Memorial Hospital, Linkuo, School of 
      Medicine, Chang Gung University, No. 5, Fu-hsin Street, Kweishan, Taoyuan 333, 
      Taiwan.
FAU - Jung, Shih-Ming
AU  - Jung SM
AD  - Department of Pathology, Chang Gung Memorial Hospital, Linkuo, School of 
      Medicine, Chang Gung University, Taoyuan, Taiwan.
FAU - Lee, Shih-Tseng
AU  - Lee ST
AD  - Department of Neurosurgery, Chang Gung Memorial Hospital, Linkuo, School of 
      Medicine, Chang Gung University, No. 5, Fu-hsin Street, Kweishan, Taoyuan 333, 
      Taiwan.
FAU - Chang, Chen-Nen
AU  - Chang CN
AD  - Department of Neurosurgery, Chang Gung Memorial Hospital, Linkuo, School of 
      Medicine, Chang Gung University, No. 5, Fu-hsin Street, Kweishan, Taoyuan 333, 
      Taiwan.
FAU - Wei, Kuo-Chen
AU  - Wei KC
AD  - Department of Neurosurgery, Chang Gung Memorial Hospital, Linkuo, School of 
      Medicine, Chang Gung University, No. 5, Fu-hsin Street, Kweishan, Taoyuan 333, 
      Taiwan.
FAU - Hsu, Yung-Hsin
AU  - Hsu YH
AD  - Department of Neurosurgery, Chang Gung Memorial Hospital, Linkuo, School of 
      Medicine, Chang Gung University, No. 5, Fu-hsin Street, Kweishan, Taoyuan 333, 
      Taiwan.
FAU - Wu, Chieh-Tsai
AU  - Wu CT
AD  - Department of Neurosurgery, Chang Gung Memorial Hospital, Linkuo, School of 
      Medicine, Chang Gung University, No. 5, Fu-hsin Street, Kweishan, Taoyuan 333, 
      Taiwan.
FAU - Liao, Cheng-Chih
AU  - Liao CC
AD  - Department of Neurosurgery, Chang Gung Memorial Hospital, Linkuo, School of 
      Medicine, Chang Gung University, No. 5, Fu-hsin Street, Kweishan, Taoyuan 333, 
      Taiwan.
FAU - Lin, Chih-Lung
AU  - Lin CL
AD  - Department of Neurosurgery, Chang Gung Memorial Hospital, Linkuo, School of 
      Medicine, Chang Gung University, No. 5, Fu-hsin Street, Kweishan, Taoyuan 333, 
      Taiwan.
FAU - Lu, Yu-Jen
AU  - Lu YJ
AD  - Department of Neurosurgery, Chang Gung Memorial Hospital, Linkuo, School of 
      Medicine, Chang Gung University, No. 5, Fu-hsin Street, Kweishan, Taoyuan 333, 
      Taiwan.
FAU - Huang, Yin-Cheng
AU  - Huang YC
AD  - Department of Neurosurgery, Chang Gung Memorial Hospital, Linkuo, School of 
      Medicine, Chang Gung University, No. 5, Fu-hsin Street, Kweishan, Taoyuan 333, 
      Taiwan. Electronic address: ns3068@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20131003
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain Neoplasms/*diagnostic imaging/mortality
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuroectodermal Tumors, Primitive/*diagnostic imaging/mortality
MH  - Radiography
MH  - Retrospective Studies
MH  - Supratentorial Neoplasms/*diagnostic imaging/mortality
MH  - Survival Rate/trends
MH  - Young Adult
OTO - NOTNLM
OT  - Chemotherapy
OT  - Extra-pineal
OT  - Primitive neuroectodermal tumor
OT  - Prognosis
OT  - Radiation therapy
EDAT- 2014/01/28 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/01/28 06:00
PHST- 2013/03/06 00:00 [received]
PHST- 2013/07/15 00:00 [revised]
PHST- 2013/07/15 00:00 [accepted]
PHST- 2014/01/28 06:00 [entrez]
PHST- 2014/01/28 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0967-5868(13)00509-2 [pii]
AID - 10.1016/j.jocn.2013.07.025 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2014 May;21(5):803-9. doi: 10.1016/j.jocn.2013.07.025. Epub 2013 
      Oct 3.