PMID- 24463096
OWN - NLM
STAT- MEDLINE
DCOM- 20140421
LR  - 20140303
IS  - 1096-0333 (Electronic)
IS  - 0041-008X (Linking)
VI  - 275
IP  - 2
DP  - 2014 Mar 1
TI  - Maternal glucocorticoid elevation and associated blood metabonome changes might 
      be involved in metabolic programming of intrauterine growth retardation in rats 
      exposed to caffeine prenatally.
PG  - 79-87
LID - S0041-008X(14)00015-5 [pii]
LID - 10.1016/j.taap.2014.01.007 [doi]
AB  - Our previous studies demonstrated that prenatal caffeine exposure causes 
      intrauterine growth retardation (IUGR), fetuses are over-exposed to high levels 
      of maternal glucocorticoids (GC), and intrauterine metabolic programming and 
      associated metabonome alteration that may be GC-mediated. However, whether 
      maternal metabonomes would be altered and relevant metabolite variations might 
      mediate the development of IUGR remained unknown. In the present studies, we 
      examined the dose- and time-effects of caffeine on maternal metabonome, and tried 
      to clarify the potential roles of maternal GCs and metabonome changes in the 
      metabolic programming of caffeine-induced IUGR. Pregnant rats were treated with 
      caffeine (0, 20, 60 or 180 mg/kg.d) from gestational days (GD) 11 to 20, or 180 
      mg/kg.d caffeine from GD9. Metabonomes of maternal plasma on GD20 in the 
      dose-effect study and on GD11, 14 and 17 in the time-course study were analyzed 
      by (1)H nuclear magnetic resonance spectroscopy, respectively. Caffeine 
      administration reduced maternal weight gains and elevated both maternal and fetal 
      corticosterone (CORT) levels. A negative correlation between maternal/fetal CORT 
      levels and fetal bodyweight was observed. The maternal metabonome alterations 
      included attenuated metabolism of carbohydrates, enhanced lipolysis and protein 
      breakdown, and amino acid accumulation, suggesting GC-associated metabolic 
      effects. GC-associated metabolite variations (alpha/beta-glucoses, high density 
      lipoprotein-cholesterol, beta-hydroxybutyrate) were observed early following 
      caffeine administration. In conclusion, prenatal caffeine exposure induced 
      maternal GC elevation and metabonome alteration, and maternal GC and relevant 
      discriminatory metabolites might be involved in the metabolic programming of 
      caffeine-induced IUGR.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Kou, Hao
AU  - Kou H
AD  - Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 
      430071, China.
FAU - Liu, Yansong
AU  - Liu Y
AD  - Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 
      430071, China.
FAU - Liang, Gai
AU  - Liang G
AD  - Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 
      430071, China.
FAU - Huang, Jing
AU  - Huang J
AD  - Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 
      430071, China.
FAU - Hu, Jieqiong
AU  - Hu J
AD  - Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 
      430071, China.
FAU - Yan, You-e
AU  - Yan YE
AD  - Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 
      430071, China.
FAU - Li, Xiaojun
AU  - Li X
AD  - Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 
      430071, China.
FAU - Yu, Hong
AU  - Yu H
AD  - Hubei Provincial Key Laboratory of Developmentally Originated Diseases, Wuhan 
      430071, China.
FAU - He, Xiaohua
AU  - He X
AD  - Hubei Provincial Key Laboratory of Developmentally Originated Diseases, Wuhan 
      430071, China.
FAU - Zhang, Baifang
AU  - Zhang B
AD  - Hubei Provincial Key Laboratory of Developmentally Originated Diseases, Wuhan 
      430071, China.
FAU - Zhang, Yuanzhen
AU  - Zhang Y
AD  - Hubei Provincial Key Laboratory of Developmentally Originated Diseases, Wuhan 
      430071, China; Center for Reproductive Medicine, Zhongnan Hospital of Wuhan 
      University, Wuhan 430071, China.
FAU - Feng, Jianghua
AU  - Feng J
AD  - Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and 
      Magnetic Resonance, Xiamen University, Xiamen 361005, China. Electronic address: 
      jianghua.feng@xmu.edu.cn.
FAU - Wang, Hui
AU  - Wang H
AD  - Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 
      430071, China; Hubei Provincial Key Laboratory of Developmentally Originated 
      Diseases, Wuhan 430071, China. Electronic address: wanghui19@whu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140123
PL  - United States
TA  - Toxicol Appl Pharmacol
JT  - Toxicology and applied pharmacology
JID - 0416575
RN  - 0 (Glucocorticoids)
RN  - 3G6A5W338E (Caffeine)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Caffeine/*adverse effects
MH  - Corticosterone/blood
MH  - Dose-Response Relationship, Drug
MH  - Drug Synergism
MH  - Female
MH  - Fetal Growth Retardation/*blood/etiology/pathology
MH  - Fetal Weight/drug effects
MH  - Fetus/drug effects
MH  - Glucocorticoids/*blood
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Maternal Nutritional Physiological Phenomena
MH  - Metabolome
MH  - Multivariate Analysis
MH  - Pregnancy
MH  - Rats
MH  - Rats, Wistar
MH  - Time Factors
OTO - NOTNLM
OT  - Caffeine
OT  - Intrauterine growth retardation
OT  - Maternal glucocorticoid
OT  - Metabolic programming
OT  - Metabonome
EDAT- 2014/01/28 06:00
MHDA- 2014/04/22 06:00
CRDT- 2014/01/28 06:00
PHST- 2013/10/01 00:00 [received]
PHST- 2014/01/12 00:00 [revised]
PHST- 2014/01/13 00:00 [accepted]
PHST- 2014/01/28 06:00 [entrez]
PHST- 2014/01/28 06:00 [pubmed]
PHST- 2014/04/22 06:00 [medline]
AID - S0041-008X(14)00015-5 [pii]
AID - 10.1016/j.taap.2014.01.007 [doi]
PST - ppublish
SO  - Toxicol Appl Pharmacol. 2014 Mar 1;275(2):79-87. doi: 10.1016/j.taap.2014.01.007. 
      Epub 2014 Jan 23.