PMID- 24464099
OWN - NLM
STAT- MEDLINE
DCOM- 20141106
LR  - 20181202
IS  - 1752-8984 (Electronic)
IS  - 1479-1641 (Linking)
VI  - 11
IP  - 2
DP  - 2014 Mar
TI  - Resveratrol ameliorates diabetic vascular inflammation and macrophage 
      infiltration in db/db mice by inhibiting the NF-kappaB pathway.
PG  - 92-102
LID - 10.1177/1479164113520332 [doi]
AB  - In this study, resveratrol (RSV) - a potent sirtuin 1 activator - was found to 
      have beneficial effects on glucolipid metabolism and improve inflammatory 
      mediators and markers of oxidative stress. Diabetic (db/db) mice and non-diabetic 
      C57BL/6J mice were used in the study. The db/db mice were treated with or without 
      0.3% RSV mixed with chow for 8 weeks. Dietary RSV significantly lowered blood 
      glucose, plasma lipid and free fatty acid levels in db/db mice. RSV markedly 
      inhibited the expression of intercellular adhesion molecule-1 (ICAM-1), 
      endothelial vascular cell adhesion molecule-1 (VCAM-1) and monocyte 
      chemoattractant protein-1 (MCP-1) in the aorta and the blood plasma of db/db mice 
      (p < 0.05). Levels of mac-3-positive macrophages (measure of the infiltration of 
      activated macrophages) were lower in RSV-treated diabetic mice than in their 
      untreated counterparts (p < 0.05). RSV treatment reduced the activity of the 
      transcriptional regulator nuclear factor kappa B (NF-kappaB) in aortic tissues (p < 
      0.05). Thus, RSV treatment reduced ICAM-1, VCAM-1 and MCP-1 expression in the 
      aorta and ICAM-1, VCAM-1 and MCP-1 levels in the plasma of diabetic mice. Since 
      dietary supplementation with RSV also reduced NF-kappaB activities in the aorta, the 
      therapeutic effects of RSV might be associated with the downregulation of NF-kappaB.
FAU - Guo, Rong
AU  - Guo R
AD  - Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine, Shanghai, PR China.
FAU - Liu, Baoxin
AU  - Liu B
FAU - Wang, Ke
AU  - Wang K
FAU - Zhou, Shunping
AU  - Zhou S
FAU - Li, Weiming
AU  - Li W
FAU - Xu, Yawei
AU  - Xu Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140123
PL  - England
TA  - Diab Vasc Dis Res
JT  - Diabetes & vascular disease research
JID - 101234011
RN  - 0 (Antigens, Differentiation)
RN  - 0 (Blood Glucose)
RN  - 0 (Chemokine CCL2)
RN  - 0 (NF-kappa B)
RN  - 0 (Stilbenes)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 0 (monocyte-macrophage differentiation antigen)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - Antigens, Differentiation/metabolism
MH  - Blood Glucose/metabolism
MH  - Chemokine CCL2/*drug effects/metabolism
MH  - Diabetes Complications/*metabolism
MH  - Diabetes Mellitus
MH  - Inflammation/drug therapy
MH  - Intercellular Adhesion Molecule-1/metabolism
MH  - Macrophages/*drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - NF-kappa B/metabolism
MH  - Resveratrol
MH  - Signal Transduction/*drug effects
MH  - Stilbenes/*pharmacology
MH  - Vascular Cell Adhesion Molecule-1/metabolism
OTO - NOTNLM
OT  - Diabetes
OT  - NF-kappaB
OT  - SIRT1
OT  - resveratrol
OT  - vascular inflammation
EDAT- 2014/01/28 06:00
MHDA- 2014/11/07 06:00
CRDT- 2014/01/28 06:00
PHST- 2014/01/28 06:00 [entrez]
PHST- 2014/01/28 06:00 [pubmed]
PHST- 2014/11/07 06:00 [medline]
AID - 1479164113520332 [pii]
AID - 10.1177/1479164113520332 [doi]
PST - ppublish
SO  - Diab Vasc Dis Res. 2014 Mar;11(2):92-102. doi: 10.1177/1479164113520332. Epub 
      2014 Jan 23.