PMID- 24464584
OWN - NLM
STAT- MEDLINE
DCOM- 20150615
LR  - 20220311
IS  - 1573-2576 (Electronic)
IS  - 0360-3997 (Print)
IS  - 0360-3997 (Linking)
VI  - 37
IP  - 3
DP  - 2014 Jun
TI  - Aging reduces the expression of lung CINC and MCP-1 mRNA in a P. aeruginosa rat 
      model of infection.
PG  - 933-41
LID - 10.1007/s10753-014-9813-5 [doi]
AB  - We investigated dynamic changes of inflammatory cell infiltration and expression 
      of cytokine-induced neutrophil chemoattractant (CINC) and monocyte 
      chemoattractant protein-1 (MCP-1) mRNA in aged rats with Pseudomonas aeruginosa 
      pulmonary infection. Disease manifestation and lung tissue pathology (lesion 
      dispersion, inflammatory reactions, tissue edema and bleeding) were more severe 
      in aged rats than young rats. At various time points, lung tissue 
      polymorphonuclear neutrophil and mononuclear macrophage numbers were lower in the 
      aged group than the young group (P < 0.05), and at 24 h there was no difference 
      in mononuclear macrophage numbers. After inoculation with P. aeruginosa, CINC and 
      MCP-1 mRNA expression increased in both groups, but the peak lagged in old rats 
      compared with young. Thus, aging can reduce the expression of CINC and MCP-1 mRNA 
      in lung tissues, and reduce the infiltration of neutrophils and 
      monocyte-macrophages induced by CINC and MCP-1. This might lead to increased risk 
      of pneumonia in elderly patients.
FAU - Wen, Jie
AU  - Wen J
AD  - Department of Respiratory Medicine, Traditional Chinese Medical of Xinjiang Uygur 
      Autonomous Region, Xinjiang, 830000, China.
FAU - Li, Cheng-Mei
AU  - Li CM
FAU - Gu, Li
AU  - Gu L
FAU - Yin, Shao-jun
AU  - Yin SJ
FAU - Li, Wei
AU  - Li W
FAU - Yang, Rong
AU  - Yang R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Inflammation
JT  - Inflammation
JID - 7600105
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CXCL1)
RN  - 0 (Cxcl1 protein, rat)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Age Factors
MH  - Aging
MH  - Animals
MH  - Bacterial Load/*immunology
MH  - Chemokine CCL2/*biosynthesis/genetics
MH  - Chemokine CXCL1/*biosynthesis/genetics
MH  - Inflammation/immunology/microbiology
MH  - Lung/microbiology/pathology
MH  - Macrophages/immunology
MH  - Male
MH  - Neutrophils/immunology
MH  - Pseudomonas Infections/*epidemiology
MH  - Pseudomonas aeruginosa/*pathogenicity
MH  - RNA, Messenger
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Risk
PMC - PMC4032638
EDAT- 2014/01/28 06:00
MHDA- 2015/06/16 06:00
PMCR- 2014/01/25
CRDT- 2014/01/28 06:00
PHST- 2014/01/28 06:00 [entrez]
PHST- 2014/01/28 06:00 [pubmed]
PHST- 2015/06/16 06:00 [medline]
PHST- 2014/01/25 00:00 [pmc-release]
AID - 9813 [pii]
AID - 10.1007/s10753-014-9813-5 [doi]
PST - ppublish
SO  - Inflammation. 2014 Jun;37(3):933-41. doi: 10.1007/s10753-014-9813-5.