PMID- 24464596
OWN - NLM
STAT- MEDLINE
DCOM- 20141009
LR  - 20140127
IS  - 1439-3646 (Electronic)
IS  - 0947-7349 (Linking)
VI  - 122
IP  - 1
DP  - 2014 Jan
TI  - Benefits of the neutrophil-to-lymphocyte ratio for the prediction of gestational 
      diabetes mellitus in pregnant women.
PG  - 39-43
LID - 10.1055/s-0033-1361087 [doi]
AB  - AIMS: There is growing consensus in the literature that inflammation plays a 
      central role in the pathophysiology of obesity, Type 2 Diabetes Mellitus (T2DM), 
      Gestational Diabetes Mellitus (GDM) and cardiovascular complications. Measuring 
      the neutrophil-to-lymphocyte ratio (NLR) provides a simple inexpensive method for 
      the assessment of inflammatory status. We investigated the predictive value of 
      pre-procedural (before the oral glucose tolerance test (OGTT)) NLR on the 
      development of GDM in pregnancy. METHODS: 42 women with GDM and 68 women without 
      GDM were included in the study. Complete Blood Count and biochemical tests were 
      followed by a diagnostic 4-point 100-g-OGTT within 2 weeks. GDM was diagnosed by 
      the Carpenter and Coustan criteria. The NLR was calculated from the data. 
      RESULTS: The mean NLR level was significantly higher in GDM women (3.00+/-0.83 vs. 
      2.26+/-0.43 p<0.001, respectively). In ROC analysis, NLR>2.93 had 76.2% sensitivity 
      and 94.1% specificity in predicting GDM. Logistic regression analysis showed that 
      elevated NLR (OR: 5.512, 95% CI: 1.352-22.475, p=0.017) was an independent 
      variable for predicting GDM in pregnancy. CONCLUSIONS: An elevated NLR level is a 
      powerful and independent predictor of GDM. The results of this study suggested 
      that inflammation plays a central role in the pathogenesis of GDM.
CI  - (c) J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart . New York.
FAU - Yilmaz, H
AU  - Yilmaz H
AD  - Turgut Ozal University, School of Medicine, Internal Medicine, Ankara, Turkey.
FAU - Celik, H T
AU  - Celik HT
AD  - Turgut Ozal University, School of Medicine, Biochemistry, Ankara, Turkey.
FAU - Namuslu, M
AU  - Namuslu M
AD  - Turgut Ozal University, School of Medicine, Biochemistry, Ankara, Turkey.
FAU - Inan, O
AU  - Inan O
AD  - Turgut Ozal University, School of Medicine, Internal Medicine, Ankara, Turkey.
FAU - Onaran, Y
AU  - Onaran Y
AD  - Turgut Ozal University, School of Medicine, Obstetrics and Gynecology, Ankara, 
      Turkey.
FAU - Karakurt, F
AU  - Karakurt F
AD  - Necmettin Erbakan University, School of Medicine Konya, Turkey.
FAU - Ayyildiz, A
AU  - Ayyildiz A
AD  - Agn State Hospital, Biochemistry, Agn, Turkey.
FAU - Bilgic, M A
AU  - Bilgic MA
AD  - Turgut Ozal University, School of Medicine, Internal Medicine, Ankara, Turkey.
FAU - Bavbek, N
AU  - Bavbek N
AD  - Turgut Ozal University, School of Medicine, Internal Medicine, Ankara, Turkey.
FAU - Akcay, A
AU  - Akcay A
AD  - Turgut Ozal University, School of Medicine, Internal Medicine, Ankara, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20140124
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German 
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Diabetes, Gestational/blood/*diagnosis/immunology
MH  - Female
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Leukocyte Count
MH  - Lymphocytes/*cytology
MH  - Neutrophils/*cytology
MH  - Predictive Value of Tests
MH  - Pregnancy
MH  - Prognosis
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2014/01/28 06:00
MHDA- 2014/10/10 06:00
CRDT- 2014/01/28 06:00
PHST- 2014/01/28 06:00 [entrez]
PHST- 2014/01/28 06:00 [pubmed]
PHST- 2014/10/10 06:00 [medline]
AID - 10.1055/s-0033-1361087 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2014 Jan;122(1):39-43. doi: 10.1055/s-0033-1361087. 
      Epub 2014 Jan 24.