PMID- 24464971
OWN - NLM
STAT- MEDLINE
DCOM- 20141106
LR  - 20140820
IS  - 1545-5017 (Electronic)
IS  - 1545-5009 (Linking)
VI  - 61
IP  - 10
DP  - 2014 Oct
TI  - Loss of mismatched HLA in myeloid/NK cell precursor acute leukemia relapse after 
      T cell-replete haploidentical hematopoietic stem cell transplantation.
PG  - 1880-2
LID - 10.1002/pbc.24962 [doi]
AB  - Myeloid/natural killer cell precursor acute leukemia (MNKL) is an aggressive 
      disease with a high relapse rate even after allogeneic hematopoietic stem cell 
      transplantation (SCT). We report a patient with MNKL who had a donor lymphocyte 
      infusion (DLI) for relapse after T cell-replete human leukocyte antigen 
      (HLA)-haploidentical SCT, but relapsed again 20 months later with loss of 
      mismatched HLA. This case suggests that a strong graft-versus-leukemia effect of 
      haploidentical SCT can be expected in MNKL patients. In the haploidentical 
      setting, DLI should be considered for patients with relapsed leukemia whose 
      leukemic cells have not lost HLA cell surface expression.
CI  - (c) 2014 Wiley Periodicals, Inc.
FAU - Kobayashi, Shogo
AU  - Kobayashi S
AD  - Department of Pediatrics, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
FAU - Kikuta, Atsushi
AU  - Kikuta A
FAU - Ito, Masaki
AU  - Ito M
FAU - Sano, Hideki
AU  - Sano H
FAU - Mochizuki, Kazuhiro
AU  - Mochizuki K
FAU - Akaihata, Mitsuko
AU  - Akaihata M
FAU - Waragai, Tomoko
AU  - Waragai T
FAU - Ohara, Yoshihiro
AU  - Ohara Y
FAU - Ogawa, Chitose
AU  - Ogawa C
FAU - Ono, Satoshi
AU  - Ono S
FAU - Ohto, Hitoshi
AU  - Ohto H
FAU - Hosoya, Mitsuaki
AU  - Hosoya M
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20140125
PL  - United States
TA  - Pediatr Blood Cancer
JT  - Pediatric blood & cancer
JID - 101186624
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Graft vs Host Disease/immunology
MH  - HLA Antigens/*immunology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Killer Cells, Natural/pathology
MH  - Leukemia, Myeloid, Acute/*immunology/surgery
MH  - Male
MH  - Neoplasm Recurrence, Local/*immunology
OTO - NOTNLM
OT  - BMT
OT  - acute
OT  - graft versus host disease
OT  - hematology/oncology
OT  - leukemias
OT  - rare tumors
OT  - stem cell transplantation
EDAT- 2014/01/28 06:00
MHDA- 2014/11/07 06:00
CRDT- 2014/01/28 06:00
PHST- 2013/08/29 00:00 [received]
PHST- 2014/01/06 00:00 [accepted]
PHST- 2014/01/28 06:00 [entrez]
PHST- 2014/01/28 06:00 [pubmed]
PHST- 2014/11/07 06:00 [medline]
AID - 10.1002/pbc.24962 [doi]
PST - ppublish
SO  - Pediatr Blood Cancer. 2014 Oct;61(10):1880-2. doi: 10.1002/pbc.24962. Epub 2014 
      Jan 25.