PMID- 24465375
OWN - NLM
STAT- MEDLINE
DCOM- 20141111
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 1
DP  - 2014
TI  - BDNF polymorphisms are linked to poorer working memory performance, reduced 
      cerebellar and hippocampal volumes and differences in prefrontal cortex in a 
      Swedish elderly population.
PG  - e82707
LID - 10.1371/journal.pone.0082707 [doi]
LID - e82707
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) links learning, memory and 
      cognitive decline in elderly, but evidence linking BDNF allele variation, 
      cognition and brain structural differences is lacking. METHODS: 367 elderly 
      Swedish men (n = 181) and women (n = 186) from Prospective Investigation of the 
      Vasculature in Uppsala seniors (PIVUS) were genotyped and the BDNF functional 
      rs6265 SNP was further examined in subjects who completed the Trail Making Task 
      (TMT), verbal fluency task, and had a magnetic resonance imaging (MRI) scan. 
      Voxel-based morphometry (VBM) examined brain structure, cognition and links with 
      BDNF. RESULTS: The functional BDNF SNP (rs6265,) predicted better working memory 
      performance on the TMT with positive association of the Met rs6265, and was 
      linked with greater cerebellar, precuneus, left superior frontal gyrus and 
      bilateral hippocampal volume, and reduced brainstem and bilateral posterior 
      cingulate volumes. CONCLUSIONS: The functional BDNF polymorphism influences brain 
      volume in regions associated with memory and regulation of sensorimotor control, 
      with the Met rs6265 allele potentially being more beneficial to these functions 
      in the elderly.
FAU - Brooks, Samantha J
AU  - Brooks SJ
AD  - Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, 
      Sweden ; Department of Psychiatry and Mental Health, Faculty of Health Sciences, 
      University of Cape Town, Observatory, Cape Town, South Africa.
FAU - Nilsson, Emil K
AU  - Nilsson EK
AD  - Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, 
      Sweden.
FAU - Jacobsson, Josefin A
AU  - Jacobsson JA
AD  - Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, 
      Sweden.
FAU - Stein, Dan J
AU  - Stein DJ
AD  - Department of Psychiatry and Mental Health, Faculty of Health Sciences, 
      University of Cape Town, Observatory, Cape Town, South Africa.
FAU - Fredriksson, Robert
AU  - Fredriksson R
AD  - Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, 
      Sweden.
FAU - Lind, Lars
AU  - Lind L
AD  - Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
FAU - Schioth, Helgi B
AU  - Schioth HB
AD  - Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, 
      Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140123
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - Cerebellum/*anatomy & histology/physiology
MH  - Executive Function
MH  - Female
MH  - Functional Neuroimaging
MH  - Gene Expression
MH  - Genetic Association Studies
MH  - Hippocampus/*anatomy & histology/physiology
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - *Memory, Short-Term
MH  - Organ Size
MH  - *Polymorphism, Single Nucleotide
MH  - Prefrontal Cortex/*anatomy & histology/physiology
MH  - Prospective Studies
PMC - PMC3900399
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/01/28 06:00
MHDA- 2014/11/12 06:00
PMCR- 2014/01/23
CRDT- 2014/01/28 06:00
PHST- 2013/05/27 00:00 [received]
PHST- 2013/10/26 00:00 [accepted]
PHST- 2014/01/28 06:00 [entrez]
PHST- 2014/01/28 06:00 [pubmed]
PHST- 2014/11/12 06:00 [medline]
PHST- 2014/01/23 00:00 [pmc-release]
AID - PONE-D-13-21597 [pii]
AID - 10.1371/journal.pone.0082707 [doi]
PST - epublish
SO  - PLoS One. 2014 Jan 23;9(1):e82707. doi: 10.1371/journal.pone.0082707. eCollection 
      2014.