PMID- 24465716
OWN - NLM
STAT- MEDLINE
DCOM- 20141111
LR  - 20230424
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 1
DP  - 2014
TI  - Fructose-bisphosphate aldolase a is a potential metastasis-associated marker of 
      lung squamous cell carcinoma and promotes lung cell tumorigenesis and migration.
PG  - e85804
LID - 10.1371/journal.pone.0085804 [doi]
LID - e85804
AB  - Fructose-bisphosphate aldolase A (ALDOA) is a key enzyme in glycolysis and is 
      responsible for catalyzing the reversible conversion of fructose-1,6-bisphosphate 
      to glyceraldehydes-3-phosphate and dihydroxyacetone phosphate. ALDOA contributes 
      to various cellular functions such as muscle maintenance, regulation of cell 
      shape and mobility, striated muscle contraction, actin filament organization and 
      ATP biosynthetic process. Here, we reported that ALDOA is a highly expressed in 
      lung squamous cell carcinoma (LSCC) and its expression level is correlated with 
      LSCC metastasis, grades, differentiation status and poor prognosis. Depletion of 
      ALDOA expression in the lung squamous carcinoma NCI-H520 cells reduces the 
      capabilities of cell motility and tumorigenesis. These data suggest that ALDOA 
      could be a potential marker for LSCC metastasis and a therapeutic target for drug 
      development.
FAU - Du, Sha
AU  - Du S
AD  - Department of Histology and Embryology, Dalian Medical University, Liaoning, 
      China ; Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, 
      Liaoning, China.
FAU - Guan, Zhuzhu
AU  - Guan Z
AD  - Department of Histology and Embryology, Dalian Medical University, Liaoning, 
      China ; Liaoning Key Laboratory of Proteomics, Dalian Medical University, 
      Liaoning, China.
FAU - Hao, Lihong
AU  - Hao L
AD  - Department of Histology and Embryology, Dalian Medical University, Liaoning, 
      China.
FAU - Song, Yang
AU  - Song Y
AD  - Department of Histology and Embryology, Dalian Medical University, Liaoning, 
      China.
FAU - Wang, Lan
AU  - Wang L
AD  - Department of Histology and Embryology, Dalian Medical University, Liaoning, 
      China.
FAU - Gong, Linlin
AU  - Gong L
AD  - Department of Histology and Embryology, Dalian Medical University, Liaoning, 
      China.
FAU - Liu, Lu
AU  - Liu L
AD  - Department of Histology and Embryology, Dalian Medical University, Liaoning, 
      China.
FAU - Qi, Xiaoyu
AU  - Qi X
AD  - Department of Histology and Embryology, Dalian Medical University, Liaoning, 
      China.
FAU - Hou, Zhaoyuan
AU  - Hou Z
AD  - Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Liaoning, 
      China.
FAU - Shao, Shujuan
AU  - Shao S
AD  - Department of Histology and Embryology, Dalian Medical University, Liaoning, 
      China ; Liaoning Key Laboratory of Proteomics, Dalian Medical University, 
      Liaoning, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140123
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Biomarkers, Tumor)
RN  - EC 4.1.2.13 (Fructose-Bisphosphate Aldolase)
SB  - IM
ECI - PLoS One. 2023 Apr 24;18(4):e0285076. PMID: 37093885
MH  - Adult
MH  - Aged
MH  - Amino Acid Sequence
MH  - Animals
MH  - Biomarkers, Tumor/*metabolism
MH  - Carcinoma, Squamous Cell/*enzymology/mortality/secondary
MH  - Cell Line, Tumor
MH  - Cytoplasm/enzymology
MH  - Female
MH  - Fructose-Bisphosphate Aldolase/*metabolism
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Lung Neoplasms/*enzymology/mortality/pathology
MH  - Male
MH  - Mice
MH  - Mice, Nude
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Neoplasm Grading
MH  - Neoplasm Transplantation
PMC - PMC3900443
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/01/28 06:00
MHDA- 2014/11/12 06:00
PMCR- 2014/01/23
CRDT- 2014/01/28 06:00
PHST- 2013/07/16 00:00 [received]
PHST- 2013/12/02 00:00 [accepted]
PHST- 2014/01/28 06:00 [entrez]
PHST- 2014/01/28 06:00 [pubmed]
PHST- 2014/11/12 06:00 [medline]
PHST- 2014/01/23 00:00 [pmc-release]
AID - PONE-D-13-29290 [pii]
AID - 10.1371/journal.pone.0085804 [doi]
PST - epublish
SO  - PLoS One. 2014 Jan 23;9(1):e85804. doi: 10.1371/journal.pone.0085804. eCollection 
      2014.