PMID- 24466108
OWN - NLM
STAT- MEDLINE
DCOM- 20150128
LR  - 20220331
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 1
DP  - 2014
TI  - Plasma D-dimer levels are associated with stroke subtypes and infarction volume 
      in patients with acute ischemic stroke.
PG  - e86465
LID - 10.1371/journal.pone.0086465 [doi]
LID - e86465
AB  - BACKGROUND: It has been suggested that modestly elevated circulating D-dimer 
      values may be associated with acute ischemic stroke (AIS). Thus, the purpose of 
      this study was to investigate the association between plasma D-dimer level at 
      admission and AIS in Chinese population. METHODS: In a prospective observational 
      study, plasma D-dimer levels were measured using a particle-enhanced, 
      immunoturbidimetric assay on admission in 240 Chinese patients with AIS. The 
      National Institutes of Health Stroke Scale (NIHSS) score was assessed on 
      admission blinded to D-dimer levels. RESULTS: Plasma median D-dimer levels were 
      significantly (P = 0.000) higher in AIS patients as compared to healthy controls 
      (0.88; interquartiler range [IQR], 0.28-2.11 mg/L and 0.31; IQR, 0.17-0.74 mg/L). 
      D-dimer levels increased with increasing severity of stroke as defined by the 
      NIHSS score(r = 0.179, p = 0.005) and infarct volume(r = 0.425, p = 0.000). Those 
      positive trends still existed even after correcting for possible confounding 
      factors (P = 0.012, 0.000; respectively). Based on the Receiver operating 
      characteristic (ROC) curve, the optimal cut-off value of plasma D-dimer levels as 
      an indicator for diagnosis of cardioembolic strokes was projected to be 0.91 
      mg/L, which yielded a sensitivity of 83.7% and a specificity of 81.5%, the area 
      under the curve was 0.862(95% confidence interval [CI], 0.811-0.912). CONCLUSION: 
      We had shown that plasma D-dimer levels increased with increasing severity of 
      stroke as defined by the NIHSS score and infarct volume. These associations were 
      independent other possible variables. In addition, cardioembolic strokes can be 
      distinguished from other stroke etiologies by measuring plasma D-dimer levels 
      very early (0-48 hours from stroke symptom onset).
FAU - Zi, Wen-Jie
AU  - Zi WJ
AD  - Department of Neurology, Xin Qiao Hospital, Third Military Medical University, 
      Chongqing, P. R. China.
FAU - Shuai, Jie
AU  - Shuai J
AD  - Department of Neurology, Xin Qiao Hospital, Third Military Medical University, 
      Chongqing, P. R. China.
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20140120
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Fibrin Fibrinogen Degradation Products)
RN  - 0 (fibrin fragment D)
SB  - IM
RIN - PLoS One. 2022 Mar 30;17(3):e0266428. PMID: 35353849
MH  - Acute Disease
MH  - Aged
MH  - Brain/blood supply/*pathology
MH  - Brain Infarction/*blood/epidemiology/*pathology
MH  - China/epidemiology
MH  - Female
MH  - Fibrin Fibrinogen Degradation Products/*analysis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
PMC - PMC3896474
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/01/28 06:00
MHDA- 2015/01/30 06:00
PMCR- 2014/01/20
CRDT- 2014/01/28 06:00
PHST- 2013/10/16 00:00 [received]
PHST- 2013/12/11 00:00 [accepted]
PHST- 2014/01/28 06:00 [entrez]
PHST- 2014/01/28 06:00 [pubmed]
PHST- 2015/01/30 06:00 [medline]
PHST- 2014/01/20 00:00 [pmc-release]
AID - PONE-D-13-42253 [pii]
AID - 10.1371/journal.pone.0086465 [doi]
PST - epublish
SO  - PLoS One. 2014 Jan 20;9(1):e86465. doi: 10.1371/journal.pone.0086465. eCollection 
      2014.