PMID- 24467279
OWN - NLM
STAT- MEDLINE
DCOM- 20141228
LR  - 20171116
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 39
IP  - 8
DP  - 2014 Apr
TI  - Differential role of N-methyl-D-aspartate receptor-mediated glutamate 
      transmission in the nucleus accumbens shell and core in nicotine seeking in rats.
PG  - 1314-22
LID - 10.1111/ejn.12491 [doi]
AB  - Nicotine, a major psychoactive component of tobacco smoke, increases glutamate 
      transmission in the nucleus accumbens (NAcc). However, the role of the 
      N-methyl-D-aspartate (NMDA)-mediated glutamatergic neurotransmission in the NAcc 
      shell and core subdivisions in nicotine-dependent behaviors has not been studied. 
      The present study evaluated, in rats, the effects of bilateral administration of 
      the competitive NMDA receptor antagonist LY235959 (0, 0.1, 1, and 10 ng/0.5 
      muL/side) into the NAcc shell or core on intravenous nicotine (fixed- and 
      progressive-ratio schedules) and food (fixed-ratio schedule) self-administration, 
      and cue-induced reinstatement of nicotine-seeking behavior. In addition, the 
      effects of LY235959 injections in the NAcc shell were evaluated on 
      nicotine-induced conditioned taste aversion, a procedure that assesses the 
      aversive effects of nicotine. LY235959 injections into the NAcc shell 
      significantly increased nicotine self-administration under both fixed- and 
      progressive-ratio schedules, and decreased food self-administration, but had no 
      effect on nicotine-induced conditioned taste aversion or cue-induced nicotine 
      seeking. Furthermore, injections of LY235959 in the lateral septal nucleus, 
      originally intended as an anatomical control site for the NAcc shell, increased 
      nicotine self-administration and decreased food self-administration under the 
      fixed-ratio schedule. In contrast, LY235959 injections into the NAcc core 
      increased the cue-induced reinstatement of nicotine seeking and decreased food 
      self-administration, but had no effect on nicotine self-administration. The 
      present data suggest that NMDA receptor-mediated glutamatergic neurotransmission 
      in the NAcc shell and core differentially regulates food- and nicotine-maintained 
      responding. Importantly, the data suggest an inhibitory role for NMDA-mediated 
      glutamatergic neurotransmission in the NAcc shell and core in nicotine 
      self-administration and the cue-induced reinstatement of nicotine seeking, 
      respectively.
CI  - (c) 2014 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
FAU - D'Souza, Manoranjan S
AU  - D'Souza MS
AD  - Department of Psychiatry, M/C 0603, School of Medicine, University of California, 
      San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0603, USA.
FAU - Markou, Athina
AU  - Markou A
LA  - eng
GR  - DA11946/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140127
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Isoquinolines)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 6M3C89ZY6R (Nicotine)
RN  - AR2BHC0C6P (LY 235959)
SB  - IM
MH  - Animals
MH  - *Drug-Seeking Behavior
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Glutamic Acid/*metabolism
MH  - Isoquinolines/pharmacology
MH  - Male
MH  - Nicotine/administration & dosage/*pharmacology
MH  - Nucleus Accumbens/drug effects/*metabolism/physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/*metabolism
MH  - Self Administration
MH  - *Synaptic Transmission
OTO - NOTNLM
OT  - aversion
OT  - glutamate receptors
OT  - motivation
OT  - nucleus accumbens
OT  - progressive ratio
OT  - reward
EDAT- 2014/01/29 06:00
MHDA- 2014/12/30 06:00
CRDT- 2014/01/29 06:00
PHST- 2013/09/29 00:00 [received]
PHST- 2013/12/19 00:00 [revised]
PHST- 2013/12/22 00:00 [accepted]
PHST- 2014/01/29 06:00 [entrez]
PHST- 2014/01/29 06:00 [pubmed]
PHST- 2014/12/30 06:00 [medline]
AID - 10.1111/ejn.12491 [doi]
PST - ppublish
SO  - Eur J Neurosci. 2014 Apr;39(8):1314-22. doi: 10.1111/ejn.12491. Epub 2014 Jan 27.